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4 Results Found

  • Article
  • Open Access
2,093 Views
34 Pages

18 February 2025

Background: Pressure injuries (PIs) are increasing worldwide, and there has been no significant improvement in preventing them. Traditional assessment tools are widely used to identify a patient at risk of developing a PI. This study aims to construc...

  • Article
  • Open Access
21 Citations
6,898 Views
17 Pages

Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men

  • Pablo García-González,
  • Itziar de Rojas,
  • Sonia Moreno-Grau,
  • Laura Montrreal,
  • Raquel Puerta,
  • Emilio Alarcón-Martín,
  • Inés Quintela,
  • Adela Orellana,
  • Victor Andrade and
  • Pamela V. Martino Adami
  • + 33 authors

Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at th...

  • Systematic Review
  • Open Access
3 Citations
2,245 Views
16 Pages

Background/Objectives: Type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD) are significant global health issues. Epidemiological studies suggest T2DM increases AD risk, though confounding factors and reverse causality complicate this a...

  • Article
  • Open Access
11 Citations
5,118 Views
26 Pages

The estrogen receptors α (ERα) are transcription factors involved in several physiological processes belonging to the nuclear receptors (NRs) protein family. Besides the endogenous ligands, several other chemicals are able to bind to those receptors....