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Search Results (1,869)

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Keywords = Chang’s extent analysis

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17 pages, 8148 KiB  
Article
Inland Flood Analysis in Irrigated Agricultural Fields Including Drainage Systems and Pump Stations
by Inhyeok Song, Heesung Lim and Hyunuk An
Water 2025, 17(15), 2299; https://doi.org/10.3390/w17152299 (registering DOI) - 2 Aug 2025
Abstract
Effective flood management in agricultural fields has become increasingly important due to the rising frequency and intensity of rainfall events driven by climate change. This study investigates the applicability of urban flood analysis models—SWMM (1D) and K-Flood (2D)—to irrigated agricultural fields with artificial [...] Read more.
Effective flood management in agricultural fields has become increasingly important due to the rising frequency and intensity of rainfall events driven by climate change. This study investigates the applicability of urban flood analysis models—SWMM (1D) and K-Flood (2D)—to irrigated agricultural fields with artificial drainage systems. A case study was conducted in a rural area near the Sindae drainage station in Cheongju, South Korea, using rainfall data from an extreme weather event in 2017. The models simulated inland flooding and were validated against flood trace maps provided by the Ministry of the Interior and Safety (MOIS). Receiver Operating Characteristic (ROC) analysis showed a true positive rate of 0.565, a false positive rate of 0.21, and an overall accuracy of 0.731, indicating reasonable agreement with observed inundation. Scenario analyses were also conducted to assess the effectiveness of three improvement strategies: reducing the Manning coefficient, increasing pump station capacity, and widening drainage channels. Among them, increasing pump capacity most effectively reduced flood volume, while channel widening had the greatest impact on reducing flood extent. These findings demonstrate the potential of urban flood models for application in agricultural contexts and support data-driven planning for rural flood mitigation. Full article
36 pages, 9354 KiB  
Article
Effects of Clouds and Shadows on the Use of Independent Component Analysis for Feature Extraction
by Marcos A. Bosques-Perez, Naphtali Rishe, Thony Yan, Liangdong Deng and Malek Adjouadi
Remote Sens. 2025, 17(15), 2632; https://doi.org/10.3390/rs17152632 - 29 Jul 2025
Viewed by 129
Abstract
One of the persistent challenges in multispectral image analysis is the interference caused by dense cloud cover and its resulting shadows, which can significantly obscure surface features. This becomes especially problematic when attempting to monitor surface changes over time using satellite imagery, such [...] Read more.
One of the persistent challenges in multispectral image analysis is the interference caused by dense cloud cover and its resulting shadows, which can significantly obscure surface features. This becomes especially problematic when attempting to monitor surface changes over time using satellite imagery, such as from Landsat-8. In this study, rather than simply masking visual obstructions, we aimed to investigate the role and influence of clouds within the spectral data itself. To achieve this, we employed Independent Component Analysis (ICA), a statistical method capable of decomposing mixed signals into independent source components. By applying ICA to selected Landsat-8 bands and analyzing each component individually, we assessed the extent to which cloud signatures are entangled with surface data. This process revealed that clouds contribute to multiple ICA components simultaneously, indicating their broad spectral influence. With this influence on multiple wavebands, we managed to configure a set of components that could perfectly delineate the extent and location of clouds. Moreover, because Landsat-8 lacks cloud-penetrating wavebands, such as those in the microwave range (e.g., SAR), the surface information beneath dense cloud cover is not captured at all, making it physically impossible for ICA to recover what is not sensed in the first place. Despite these limitations, ICA proved effective in isolating and delineating cloud structures, allowing us to selectively suppress them in reconstructed images. Additionally, the technique successfully highlighted features such as water bodies, vegetation, and color-based land cover differences. These findings suggest that while ICA is a powerful tool for signal separation and cloud-related artifact suppression, its performance is ultimately constrained by the spectral and spatial properties of the input data. Future improvements could be realized by integrating data from complementary sensors—especially those operating in cloud-penetrating wavelengths—or by using higher spectral resolution imagery with narrower bands. Full article
(This article belongs to the Section Environmental Remote Sensing)
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27 pages, 2565 KiB  
Review
The Role of ESG in Driving Sustainable Innovation in Water Sector: From Gaps to Governance
by Gabriel Minea, Elena Simina Lakatos, Roxana Maria Druta, Alina Moldovan, Lucian Marius Lupu and Lucian Ionel Cioca
Water 2025, 17(15), 2259; https://doi.org/10.3390/w17152259 - 29 Jul 2025
Viewed by 372
Abstract
The water sector is facing a convergence of systemic challenges generated by climate change, increasing demand, and increasingly stringent regulations, which threaten its operational and strategic sustainability. In this context, the article examines how ESG (environmental, social, governance) principles are integrated into the [...] Read more.
The water sector is facing a convergence of systemic challenges generated by climate change, increasing demand, and increasingly stringent regulations, which threaten its operational and strategic sustainability. In this context, the article examines how ESG (environmental, social, governance) principles are integrated into the governance, financing, and management of water resources, with a comparative focus on Romania and the European Union. It aims to assess the extent to which ESG practices contribute to the sustainable transformation of the water sector in the face of growing environmental and socio-economic challenges. The methodology is based on a systematic analysis of policy documents, regulatory frameworks, and ESG standards applicable to the water sector at both national (Romania) and EU levels. This study also investigates investment strategies and their alignment with the EU Taxonomy for Sustainable Activities, enabling a comparative perspective on implementation, gaps and strengths. Findings reveal that while ESG principles are increasingly recognized across Europe, their implementation remains uneven (particularly in Romania) due to unclear standards, limited funding mechanisms, and fragmented policy coordination. ESG integration shows clear potential to foster innovation, improve governance transparency, and support long-term resilience in the water sector. These results underline the need for coherent, integrated policies and stronger institutional coordination to ensure consistent ESG adoption across Member States. Policymakers should prioritize the development of clear guidelines and supportive funding instruments to accelerate sustainable outcomes. The originality of our study lies in its comparative approach, offering an in-depth analysis of ESG integration in the water sector across different governance contexts. It provides valuable insights for advancing policy coherence, investment alignment, and sustainable water resource management at both national and European levels. Full article
(This article belongs to the Section Water Resources Management, Policy and Governance)
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27 pages, 4299 KiB  
Article
Causal Relationship Between Serum Uric Acid and Atherosclerotic Disease: A Mendelian Randomization and Transcriptomic Analysis
by Shitao Wang, Shuai Mei, Xiaozhu Ma, Qidamugai Wuyun, Li Zhou, Qiushi Luo, Ziyang Cai and Jiangtao Yan
Biomedicines 2025, 13(8), 1838; https://doi.org/10.3390/biomedicines13081838 - 28 Jul 2025
Viewed by 430
Abstract
Background/Objectives: Elevated serum uric acid levels are associated with the occurrence, development, and adverse events of coronary heart disease (CHD) and CHD risk factors. However, the extent of any pathogenic effect of the serum uric acid on CHD and whether CHD risk [...] Read more.
Background/Objectives: Elevated serum uric acid levels are associated with the occurrence, development, and adverse events of coronary heart disease (CHD) and CHD risk factors. However, the extent of any pathogenic effect of the serum uric acid on CHD and whether CHD risk factors play a confounding or mediating role are still unclear. Methods: The potential causal associations of serum uric acid with CHD were evaluated via cross-trait linkage disequilibrium score regression analysis and Mendelian randomization. The pleiotropy of genetic tools was analyzed via a Bayesian colocalization approach. Moreover, we utilized two-step MR to identify risk factors mediating the relationship between uric acid and CHD. Results: Mendelian randomization results derived from two genetic instrument selection strategies support that serum uric acid levels have a significant causal relationship with coronary artery disease, stable angina pectoris, and myocardial infarction. This causal relationship was partially mediated by diastolic blood pressure, mean arterial pressure, and serum triglycerides. Transcriptomic analysis revealed that serum uric acid may directly contribute to the development of atherosclerosis by inducing transcriptomic changes in macrophages. Conclusions: Our findings highlight that the control of serum urate concentration in the long-term management of CHD patients may be necessary. Well-designed clinical trials and foundational research are presently required to furnish conclusive proof regarding the specific clinical scenarios in which adequate reduction in urate concentrations can confer cardiovascular advantages. Full article
(This article belongs to the Special Issue Advances in Genomics and Bioinformatics of Human Disease)
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21 pages, 948 KiB  
Article
Examining the Impacts of Land Resources and Youth Education on Agricultural Livelihood in Battambang Province
by Dyna Chin, Sanara Hor, Soksan Seng, Sophak Pok, Lyhour Hin, Chaneng Yin, Sotheavy Kin, Nuch Sek, Sopharith Nou, Sokhieng Chhe, Thapkonin Chhoengsan, Pengkheang Mol, Chetha Chea, Sambath Eun, Linna Long and Hitoshi Shinjo
Sustainability 2025, 17(15), 6866; https://doi.org/10.3390/su17156866 - 28 Jul 2025
Viewed by 280
Abstract
Since the end of the Civil War, Cambodia has pursued economic development to enhance livelihoods, particularly in rural areas, where land is a critical resource. Previous studies have indicated that the country has changed land use and land cover. However, they have not [...] Read more.
Since the end of the Civil War, Cambodia has pursued economic development to enhance livelihoods, particularly in rural areas, where land is a critical resource. Previous studies have indicated that the country has changed land use and land cover. However, they have not explained how these changes can improve the livelihoods of local communities, thereby mitigating their negative impacts through an asset-based approach. Battambang Province, in the northwestern region, was the battleground until political integration in 1996. Since then, the province has been home to immigrants exploring the lands for livelihood. Thus, this study aims to examine agricultural livelihoods in the villages of Dei Kraham and Ou Toek Thla, located west of Battambang Town. These were selected because of their common characteristics. Adopting a quantitative approach and a sustainable livelihood framework, this study employed stratified random sampling to select 123 families for interviews across three population subgroups: old settlers, new settlers, and young settlers. In situ information was collected using structured questionnaires and analyzed using Kruskal–Wallis tests to assess the livelihood assets underlying the physical, natural, human, financial, and social capital. The statistical analysis results reveal no significant differences (p-value = 0.079) in livelihood assets between the strata at the village level. Meanwhile, significant differences were observed in physical, human, and financial capital between old and young settlers when examining the subgroups (p-value 0.000). The extent of the land resources held by old settlers was associated with household income and livelihoods related to agriculture. Based on livelihood asset scores, nearly half of the new settlers (0.49–0.5) and a quarter of the young settlers (0.47) are vulnerable groups requiring support. The youth will soon face an uncertain future if they do not prioritize education. Full article
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20 pages, 11478 KiB  
Article
Pore Evolution and Fractal Characteristics of Marine Shale: A Case Study of the Silurian Longmaxi Formation Shale in the Sichuan Basin
by Hongzhan Zhuang, Yuqiang Jiang, Quanzhong Guan, Xingping Yin and Yifan Gu
Fractal Fract. 2025, 9(8), 492; https://doi.org/10.3390/fractalfract9080492 - 28 Jul 2025
Viewed by 253
Abstract
The Silurian marine shale in the Sichuan Basin is currently the main reservoir for shale gas reserves and production in China. This study investigates the reservoir evolution of the Silurian marine shale based on fractal dimension, quantifying the complexity and heterogeneity of the [...] Read more.
The Silurian marine shale in the Sichuan Basin is currently the main reservoir for shale gas reserves and production in China. This study investigates the reservoir evolution of the Silurian marine shale based on fractal dimension, quantifying the complexity and heterogeneity of the shale’s pore structure. Physical simulation experiments were conducted on field-collected shale samples, revealing the evolution of total organic carbon, mineral composition, porosity, and micro-fractures. The fractal dimension of shale pore was characterized using the Frenkel–Halsey–Hill and capillary bundle models. The relationships among shale components, porosity, and fractal dimensions were investigated through a correlation analysis and a principal component analysis. A comprehensive evolution model for porosity and micro-fractures was established. The evolution of mineral composition indicates a gradual increase in quartz content, accompanied by a decline in clay, feldspar, and carbonate minerals. The thermal evolution of organic matter is characterized by the formation of organic pores and shrinkage fractures on the surface of kerogen. Retained hydrocarbons undergo cracking in the late stages of thermal evolution, resulting in the formation of numerous nanometer-scale organic pores. The evolution of inorganic minerals is represented by compaction, dissolution, and the transformation of clay minerals. Throughout the simulation, porosity evolution exhibited distinct stages of rapid decline, notable increase, and relative stabilization. Both pore volume and specific surface area exhibit a trend of decreasing initially and then increasing during thermal evolution. However, pore volume slowly decreases after reaching its peak in the late overmature stage. Fractal dimensions derived from the Frenkel–Halsey–Hill model indicate that the surface roughness of pores (D1) in organic-rich shale is generally lower than the complexity of their internal structures (D2) across different maturity levels. Additionally, the average fractal dimension calculated based on the capillary bundle model is higher, suggesting that larger pores exhibit more complex structures. The correlation matrix indicates a co-evolution relationship between shale components and pore structure. Principal component analysis results show a close relationship between the porosity of inorganic pores, microfractures, and fractal dimension D2. The porosity of organic pores, the pore volume and specific surface area of the main pore size are closely related to fractal dimension D1. D1 serves as an indicator of pore development extent and characterizes the changes in components that are “consumed” or “generated” during the evolution process. Based on mineral composition, fractal dimensions, and pore structure evolution, a comprehensive model describing the evolution of pores and fractal dimensions in organic-rich shale was established. Full article
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26 pages, 5031 KiB  
Article
Insulation Condition Assessment of High-Voltage Single-Core Cables Via Zero-Crossing Frequency Analysis of Impedance Phase Angle
by Fang Wang, Zeyang Tang, Zaixin Song, Enci Zhou, Mingzhen Li and Xinsong Zhang
Energies 2025, 18(15), 3985; https://doi.org/10.3390/en18153985 - 25 Jul 2025
Viewed by 159
Abstract
To address the limitations of low detection efficiency and poor spatial resolution of traditional cable insulation diagnosis methods, a novel cable insulation diagnosis method based on impedance spectroscopy has been proposed. An impedance spectroscopy analysis model of the frequency response of high-voltage single-core [...] Read more.
To address the limitations of low detection efficiency and poor spatial resolution of traditional cable insulation diagnosis methods, a novel cable insulation diagnosis method based on impedance spectroscopy has been proposed. An impedance spectroscopy analysis model of the frequency response of high-voltage single-core cables under different aging conditions has been established. The initial classification of insulation condition is achieved based on the impedance phase deviation between the test cable and the reference cable. Under localized aging conditions, the impedance phase spectroscopy is more than twice as sensitive to dielectric changes as the amplitude spectroscopy. Leveraging this advantage, a multi-parameter diagnostic framework is developed that integrates key spectral features such as the first phase angle zero-crossing frequency, initial phase, and resonance peak amplitude. The proposed method enables quantitative estimation of aging severity, spatial extent, and location. This technique offers a non-invasive, high-resolution solution for advanced cable health diagnostics and provides a foundation for practical deployment of power system asset management. Full article
(This article belongs to the Section F: Electrical Engineering)
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16 pages, 236 KiB  
Article
Disability Certification in Colombia: An Analysis from the Perspective of Inclusive Social Protection
by Monica Pinilla-Roncancio and Nicolas Rodriguez Caicedo
Disabilities 2025, 5(3), 66; https://doi.org/10.3390/disabilities5030066 - 25 Jul 2025
Viewed by 453
Abstract
Disability Certification is an instrument that can contribute to the identification of persons with disabilities who are potential beneficiaries of social protection programmes. In Colombia, the disability certification process was changed in 2020 to include a human rights perspective. However, little information exists [...] Read more.
Disability Certification is an instrument that can contribute to the identification of persons with disabilities who are potential beneficiaries of social protection programmes. In Colombia, the disability certification process was changed in 2020 to include a human rights perspective. However, little information exists on how far the process aligns with the recommendations made by the Convention on the Rights of Persons with Disabilities or to what extent it provides useful information for the operation of the country’s social protection system. This study aims to analyse how the changes implemented in 2020 have contributed to the identification and determination of persons with disabilities in social protection programmes in Colombia. This research uses an analytical-descriptive design, in which legal documents related to the social protection programme and disability certification were analysed. In addition, we conducted semi-structured interviews in Colombia with people with disabilities, professionals conducting the certification, and with key stakeholders, and we analysed the information using thematic analysis. Colombia changed its certification process in 2020, moving from a capacity-to-work assessment to a process of assessing functioning capacity and participation limitations following the International Classification of Functional Disability and Health. However, the new certification process has not provided an instrument to contribute to determining persons with disabilities who should be prioritised or receive social benefits in Colombia. The certification does not establish the support needs of people with disabilities, does not recommend reasonable adjustments to support their participation in society, and has not been used systematically in social protection programmes. Finally, individuals with disabilities commented that the disability certification is a process that does not open up opportunities to receive social benefits and social transfers, and in most cases, it is an expensive and lengthy process. Disability certification in Colombia is not an instrument that determines the needs of people with disabilities, nor the reasonable accommodations that they require in order to participate in society. Full article
17 pages, 1698 KiB  
Review
Quantifying the Diversity of Normative Positions in Conservation Sciences
by Rodrigue Castro Gbedomon, Kolawolé Valère Salako, Damien Delorme and Martin A. Schlaepfer
Conservation 2025, 5(3), 38; https://doi.org/10.3390/conservation5030038 - 25 Jul 2025
Viewed by 193
Abstract
What elements of nature do people involved in conservation projects seek to protect, and why? How do they identify and relate to nature? Answers to such fundamental questions are shaped by normative assumptions that can result in distinct conservation strategies and practices. Despite [...] Read more.
What elements of nature do people involved in conservation projects seek to protect, and why? How do they identify and relate to nature? Answers to such fundamental questions are shaped by normative assumptions that can result in distinct conservation strategies and practices. Despite their importance, normative assumptions are rarely explicitly stated in conservation sciences, possibly because an epistemology of modern science suggests that normative backgrounds are not relevant to the production of objective knowledge, or because researchers and practitioners are unaware of the diversity of positions that exist. Using a combination of qualitative and quantitative methods, we created a catalogue of existing normative positions in conservation literature and described their key characteristics. We described 72 distinctive normative positions about human–nature relationships. Each position was characterized by unique combinations of value-states belonging to one or more of the following five dimensions: ontology (the positionality of human with respect to nature), axiology (value systems and ethical frameworks), pragmatism (extent of human interventions), epistemology (knowledge sources), and agency (agents of change). We then scored each position in terms of its alignment (support, opposition, or neutrality) with respect to all value-states within each dimension. A fuzzy correspondence analysis revealed that the field of conservation is heterogeneous beyond the conventional gradient of intrinsic–instrumental–relational values. The frequency and circumstances under which stakeholders adopt different normative positions are unknown, but the list of dimensions and associated values provided in this study may serve as a checklist for scoping this diversity. Consideration of values stemming from alternative normative positions may help broaden support for conservation actions. Full article
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23 pages, 556 KiB  
Article
Study on Impact of Managerial Effectiveness and Digitalization on Green Total Factor Productivity of Enterprises: Sample of Listed Heavy-Polluting Enterprises in China
by Jun Yan and Zexia Zhao
Sustainability 2025, 17(15), 6700; https://doi.org/10.3390/su17156700 - 23 Jul 2025
Viewed by 292
Abstract
In the process of evaluating the quality of a company’s development, the issues related to production capacity and environmental pollution have emerged as significant concerns. Drawing on the methodologies employed in previous related research, this study utilizes the Data Envelopment Analysis with relaxation [...] Read more.
In the process of evaluating the quality of a company’s development, the issues related to production capacity and environmental pollution have emerged as significant concerns. Drawing on the methodologies employed in previous related research, this study utilizes the Data Envelopment Analysis with relaxation variables and the Global Malmquist–Luenberger index to measure the green total factor productivity of Chinese heavy-polluting enterprises. The main findings of this study are as follows: (1) It is clearly demonstrated that higher managerial effectiveness has a substantial positive impact on the improvement of a company’s green total factor productivity; (2) the digitalization progress within enterprises serves as a moderating factor in the relationship between managerial effectiveness and green total factor productivity; (3) the extent of financial constraints acts as a mediating variable, intervening in the relationship between managerial efficiency and green total factor productivity; and (4) a threshold effect is detected between managerial effectiveness and the debt repayment pressure faced by enterprises. When the threshold values of managerial effectiveness or the quick ratio are surpassed, the influence of managerial effectiveness on the green total factor productivity of enterprises will undergo a change. Full article
(This article belongs to the Special Issue Sustainable Corporate Governance and Firm Performance)
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26 pages, 11237 KiB  
Article
Reclassification Scheme for Image Analysis in GRASS GIS Using Gradient Boosting Algorithm: A Case of Djibouti, East Africa
by Polina Lemenkova
J. Imaging 2025, 11(8), 249; https://doi.org/10.3390/jimaging11080249 - 23 Jul 2025
Viewed by 448
Abstract
Image analysis is a valuable approach in a wide array of environmental applications. Mapping land cover categories depicted from satellite images enables the monitoring of landscape dynamics. Such a technique plays a key role for land management and predictive ecosystem modelling. Satellite-based mapping [...] Read more.
Image analysis is a valuable approach in a wide array of environmental applications. Mapping land cover categories depicted from satellite images enables the monitoring of landscape dynamics. Such a technique plays a key role for land management and predictive ecosystem modelling. Satellite-based mapping of environmental dynamics enables us to define factors that trigger these processes and are crucial for our understanding of Earth system processes. In this study, a reclassification scheme of image analysis was developed for mapping the adjusted categorisation of land cover types using multispectral remote sensing datasets and Geographic Resources Analysis Support System (GRASS) Geographic Information System (GIS) software. The data included four Landsat 8–9 satellite images on 2015, 2019, 2021 and 2023. The sequence of time series was used to determine land cover dynamics. The classification scheme consisting of 17 initial land cover classes was employed by logical workflow to extract 10 key land cover types of the coastal areas of Bab-el-Mandeb Strait, southern Red Sea. Special attention is placed to identify changes in the land categories regarding the thermal saline lake, Lake Assal, with fluctuating salinity and water levels. The methodology included the use of machine learning (ML) image analysis GRASS GIS modules ‘r.reclass’ for the reclassification of a raster map based on category values. Other modules included ‘r.random’, ‘r.learn.train’ and ‘r.learn.predict’ for gradient boosting ML classifier and ‘i.cluster’ and ‘i.maxlik’ for clustering and maximum-likelihood discriminant analysis. To reveal changes in the land cover categories around the Lake of Assal, this study uses ML and reclassification methods for image analysis. Auxiliary modules included ‘i.group’, ‘r.import’ and other GRASS GIS scripting techniques applied to Landsat image processing and for the identification of land cover variables. The results of image processing demonstrated annual fluctuations in the landscapes around the saline lake and changes in semi-arid and desert land cover types over Djibouti. The increase in the extent of semi-desert areas and the decrease in natural vegetation proved the processes of desertification of the arid environment in Djibouti caused by climate effects. The developed land cover maps provided information for assessing spatial–temporal changes in Djibouti. The proposed ML-based methodology using GRASS GIS can be employed for integrating techniques of image analysis for land management in other arid regions of Africa. Full article
(This article belongs to the Special Issue Self-Supervised Learning for Image Processing and Analysis)
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16 pages, 2682 KiB  
Article
Modulatory Effect of Curcumin on Expression of Methyltransferase/Demethylase in Colon Cancer Cells: Impact on wt p53, mutp53 and c-Myc
by Roberta Santarelli, Claudia Di Dio, Michele Di Crosta, Paola Currà, Roberta Gonnella and Mara Cirone
Molecules 2025, 30(15), 3054; https://doi.org/10.3390/molecules30153054 - 22 Jul 2025
Viewed by 288
Abstract
Curcumin-mediated anti-cancer properties have been correlated with the inhibition of oncogenic molecules such as mutp53 and c-Myc. Their targeting is therapeutically significant, as p53, following point mutations, can acquire oncogenic functions, and c-Myc overexpression, due to translocations, point mutations, protein/protein interactions, or epigenetic [...] Read more.
Curcumin-mediated anti-cancer properties have been correlated with the inhibition of oncogenic molecules such as mutp53 and c-Myc. Their targeting is therapeutically significant, as p53, following point mutations, can acquire oncogenic functions, and c-Myc overexpression, due to translocations, point mutations, protein/protein interactions, or epigenetic modifications, plays a central role in cancer cell proliferation and metabolic reprogramming, particularly in colorectal cancer. In a previous study, we showed that curcumin strongly downregulated mutp53 while activating wtp53 and reduced the expression of methyltransferases such as EZH2, G9a, and MLL-1 in colon cancer cells. Based on this background, here we investigated whether the dysregulation of such methyltransferases could correlate with the effect observed on p53. We also explored whether these epigenetic changes could affect c-Myc expression in these cells. By Western blot analysis and RT-qPCR, we found that the downregulation of EZH2; G9a; and, to a lesser extent, KDM1, which was also reduced by curcumin, correlated with the decrease in mutp53 and that the reduction of EZH2 and KDM1 correlated with the activation of wtp53. Regarding c-Myc, we unveiled the occurrence of a positive feedback loop between it and MLL-1, which was inhibited by curcumin, independently of the p53 status. In conclusion, this study provides new insights into the therapeutic potential of curcumin, which involves its properties to act as an epigenetic modulator and target key molecules in colon cancer cells. Full article
(This article belongs to the Special Issue Natural Compounds in Modern Therapies, 2nd Edition)
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21 pages, 2472 KiB  
Article
Threats and Opportunities for Biodiversity Conservation and Sustainable Use in the Buffer Zones of National Parks in the Brazilian Cerrado
by Ana Cristina da Silva Soares, Edson Eyji Sano, Fabiana de Góis Aquino and Tati de Almeida
Sustainability 2025, 17(14), 6597; https://doi.org/10.3390/su17146597 - 19 Jul 2025
Viewed by 413
Abstract
In recent decades, the Brazilian Cerrado has faced rapid land conversion, resulting in the loss of approximately half of its original vegetation cover. Most existing conservation units within the biome are increasingly threatened by the expansion of land use around their boundaries. The [...] Read more.
In recent decades, the Brazilian Cerrado has faced rapid land conversion, resulting in the loss of approximately half of its original vegetation cover. Most existing conservation units within the biome are increasingly threatened by the expansion of land use around their boundaries. The establishment of buffer zones with land use regulations may protect biodiversity within these protected areas. In this study, we evaluated and ranked the 10 km buffer zones of 15 national parks (NPs) located in the Cerrado biome, identifying their priority for biodiversity conservation and sustainable land use interventions. The analysis considered the following data: land use and land cover change from 2012 to 2020, extent of natural vegetation fragments, presence or absence of state and municipal conservation units within the buffer zones, and drainage density. Two multicriteria analysis methods, the analytic hierarchy process and the weighted linear combination, were applied to classify the buffer zones into five levels of threat: very high, high, moderate, low, and very low. Among the 15 buffer zones analyzed, 11 were classified as having high to very high priority for conservation actions. The buffer zones surrounding the Serra da Bodoquena, Emas, Canastra, and Brasília NPs were ranked as having very high priority. Between 2012 and 2020, the most severe reductions in ecological connectivity were observed in the buffer zones of Grande Sertão Veredas (44.5%), Nascentes do Rio Parnaíba (40.4%), and Serra das Confusões (36.7%). Given the relatively high proportion of natural vegetation in the buffer zones located in the northern Cerrado, we recommend prioritizing conservation efforts in this region. In contrast, in the southern portion of the biome, where land occupation is more intense, strategies should focus on promoting environmentally sustainable land use practices. Full article
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14 pages, 2459 KiB  
Article
Investigating the Correlation Between Corrosion-Induced Bolt Head Damage and Preload Loss Using Ultrasonic Testing
by Jay Shah, Hao Wang and Abhijit Mukherjee
Sensors 2025, 25(14), 4491; https://doi.org/10.3390/s25144491 - 19 Jul 2025
Viewed by 293
Abstract
The integrity of bolted components primarily relies on the quality of interfacial contact, which is achieved by maintaining prescribed bolt torque levels. However, challenges arise from corrosion-induced bolt head damage, potentially compromising the bolt preload, and quantifying such effects remains unanswered. Many studies [...] Read more.
The integrity of bolted components primarily relies on the quality of interfacial contact, which is achieved by maintaining prescribed bolt torque levels. However, challenges arise from corrosion-induced bolt head damage, potentially compromising the bolt preload, and quantifying such effects remains unanswered. Many studies often compare bolt corrosion’s effects to bolt loosening as both affect the interfacial contact stresses to some extent. This technical study aimed to investigate whether a correlation exists between the impact of bolt head damage and the different levels of bolt torque. Guided wave ultrasonic testing (UT) was implemented for this investigation. Laboratory experiments were conducted to monitor the transmission of ultrasonic signals across the bolted interface first during the bolt-tightening process. Once the highest bolt torque was achieved, the process was repeated for a simplified corrosion scenario, simulated by artificially damaging the bolt head in a controlled manner. The analysis focused on studying the transmission of signal energy for both scenarios. The findings revealed different trends for the signal energy transmission during bolt tightening, which are subjective to the inspection frequency. On the contrary, even at an advanced level of bolt head damage corresponding to 16% mass loss, no clear or monotonic trend was observed in the total transmitted energy. While the total energy remained relatively stable across all inspection frequencies, distinct waveform changes, such as energy redistribution and the emergence of additional wave packets, were observed. The findings emphasize the need for more advanced waveform-based analysis techniques to detect and interpret subtle changes caused by bolt degradation. Full article
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16 pages, 1624 KiB  
Article
Neurobehavioral and Oxidative Stress Effects of SiO2 Nanoparticles in Zebrafish and the Protective Role of N-Acetylcysteine
by Viorica Rarinca, Irina-Luciana Gurzu, Mircea Nicusor Nicoara, Alin Ciobica, Malina Visternicu, Catalina Ionescu, Ioana Miruna Balmus, Gabriel-Ionut Plavan, Elena Todirascu-Ciornea and Bogdan Gurzu
Biomedicines 2025, 13(7), 1762; https://doi.org/10.3390/biomedicines13071762 - 18 Jul 2025
Viewed by 409
Abstract
Background/Objectives: Silicon dioxide nanoparticles (SiO2NPs) do not exist in isolation in the environment but can interact with other substances, thus influencing their toxic effects on aquatic organisms. We assessed the combined impact of SiO2NPs and N-acetylcysteine (NAC), an antioxidant [...] Read more.
Background/Objectives: Silicon dioxide nanoparticles (SiO2NPs) do not exist in isolation in the environment but can interact with other substances, thus influencing their toxic effects on aquatic organisms. We assessed the combined impact of SiO2NPs and N-acetylcysteine (NAC), an antioxidant with the potential to counteract nanoparticle-induced oxidative stress (OS). Methods: Behavioral assessments, including the social interaction test and color preference test, were performed to evaluate neurobehavioral changes. OS biomarkers, including malondialdehyde (MDA) levels for lipid peroxidation and the activity of key antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD), were assessed to evaluate the extent of cellular damage. Results: The results indicate that prolonged exposure to SiO2NPs induces significant behavioral disruptions, including reduced exploratory behavior and increased anxiety-like responses. Furthermore, biochemical analysis revealed increased OS, suggesting nanoparticle-induced cellular toxicity. NAC co-treatment partially reversed these effects, particularly improving locomotor outcomes and antioxidant response, but was less effective on social behavior. Conclusions: These findings highlight the ecological and health risks posed by SiO2NPs and point toward the need for further toxicological studies on their long-term biological effects. Full article
(This article belongs to the Section Neurobiology and Clinical Neuroscience)
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