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Article

5 Citations

3,449 Views

21 Pages

Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer

Yiqin He,
Xiangyang Le,
Gaoyun Hu,
Qianbin Li and
Zhuo Chen

Pharmaceuticals2023, 16(2), 304;https://doi.org/10.3390/ph16020304

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15 February 2023

Cdc20 is a promising drug target that plays an important role in the mid-anaphase process of cellular mitosis, and Apcin is the only reported core structure of the Cdc20-specific inhibitor. Some potent Apcin derivatives were obtained in our previous...

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Article

3 Citations

2,300 Views

21 Pages

Targeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer

Maria Kapanidou,
Natalie L. Curtis,
Sandra S. Diaz-Minguez,
Sandra Agudo-Alvarez,
Alfredo Rus Sanchez,
Ammar Mayah,
Rosette Agena,
Paul Brennan,
Paula Morales and
Raul Benito-Arenas
+ 2 authors

Biomolecules2024, 14(11), 1439;https://doi.org/10.3390/biom14111439

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12 November 2024

Activation of the ubiquitin ligase APC/C by the protein Cdc20 is an essential requirement for proper cell division in higher organisms, including humans. APC/C is the ultimate effector of the Spindle Assembly Checkpoint (SAC), the signalling system t...

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