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Pd/Ligand-Free Synthesis of 2-Alkynylated Pyrano[4,3-d]imidazol-4-ones via One-Pot Cu-Mediated Tandem Sonogashira Coupling/Regioselective 6-endo-dig Oxacyclization Reaction

Abir Ayachi,
Abdellatif Tikad,
Vincent Lazeran,
Hassan Allouchi,
Marc Bletry,
Rafâa Besbes,
Mohamed Abarbri and
Badr Jismy

Molecules2025, 30(14), 3045;https://doi.org/10.3390/molecules30143045

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21 July 2025

Herein, we report a one-pot palladium- and ligand-free tandem Sonogashira coupling/regioselective 6-endo-dig oxacyclization reaction of 2,4-diiodo-1-methyl-imidazole-5-carboxylic acid with terminal alkynes mediated by Copper(I). This impressive appro...

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Efficient Synthesis of 1H-Benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one Derivatives Using Ag₂CO₃/TFA-Catalyzed 6-endo-dig Cyclization: Reaction Scope and Mechanistic Study

Abdelkarim El Qami,
Badr Jismy,
Mohamed Akssira,
Johan Jacquemin,
Abdellatif Tikad and
Mohamed Abarbri

Molecules2023, 28(5), 2403;https://doi.org/10.3390/molecules28052403

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6 March 2023

A small library of 1H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one derivatives was prepared in good to excellent yields, involving a Ag2CO3/TFA-catalyzed intramolecular oxacyclization of N-Boc-2-alkynylbenzimidazole substrates. In all experiments, the 6...

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2 Results Found

Pd/Ligand-Free Synthesis of 2-Alkynylated Pyrano[4,3-d]imidazol-4-ones via One-Pot Cu-Mediated Tandem Sonogashira Coupling/Regioselective 6-endo-dig Oxacyclization Reaction

Efficient Synthesis of 1H-Benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one Derivatives Using Ag2CO3/TFA-Catalyzed 6-endo-dig Cyclization: Reaction Scope and Mechanistic Study

Efficient Synthesis of 1H-Benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one Derivatives Using Ag₂CO₃/TFA-Catalyzed 6-endo-dig Cyclization: Reaction Scope and Mechanistic Study