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Article

6 Citations

4,718 Views

20 Pages

Anti-Migratory Effects of 4′-Geranyloxyferulic Acid on LPS-Stimulated U937 and HCT116 Cells via MMP-9 Down-Regulation: Involvement of ROS/ERK Signaling Pathway

Sara Franceschelli,
Daniela Maria Pia Gatta,
Alessio Ferrone,
Giulia Mezza,
Lorenza Speranza,
Mirko Pesce,
Alfredo Grilli,
Marialucia Gallorini,
Viviana di Giacomo and
Antonia Patruno
+ 5 authors

Antioxidants2020, 9(6), 470;https://doi.org/10.3390/antiox9060470

1 June 2020

Matrix metalloproteinases (MMPs) play a crucial role in tumor angiogenesis, and metastasis. 4′-geranyloxyferulic acid (GOFA) has anti-tumor and anti-inflammatory proprieties. Herein, we aimed to determine whether this compound affects cell surv...

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Article

14 Citations

3,806 Views

18 Pages

Modulation of CAT-2B-Mediated l-Arginine Uptake and Nitric Oxide Biosynthesis in HCT116 Cell Line Through Biological Activity of 4′-Geranyloxyferulic Acid Extract from Quinoa Seeds

Sara Franceschelli,
Daniela Maria Pia Gatta,
Mirko Pesce,
Alessio Ferrone,
José Luis Quiles,
Salvatore Genovese,
Francesco Epifano,
Serena Fiorito,
Vito Alessandro Taddeo and
Lorenza Speranza
+ 3 authors

Int. J. Mol. Sci.2019, 20(13), 3262;https://doi.org/10.3390/ijms20133262

2 July 2019

Chenopodium quinoa Wild is a “pseudocereal” grain which attracts a lot of attention in the scientific community as it has a positive effect on health. Here, we investigate the presence of biologically active O-prenylated phenylpropanoids...

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Article

42 Citations

6,533 Views

11 Pages

Auraptene and Other Prenyloxyphenylpropanoids Suppress Microglial Activation and Dopaminergic Neuronal Cell Death in a Lipopolysaccharide-Induced Model of Parkinson’s Disease

Satoshi Okuyama,
Tomoki Semba,
Nobuki Toyoda,
Francesco Epifano,
Salvatore Genovese,
Serena Fiorito,
Vito Alessandro Taddeo,
Atsushi Sawamoto,
Mitsunari Nakajima and
Yoshiko Furukawa

Int. J. Mol. Sci.2016, 17(10), 1716;https://doi.org/10.3390/ijms17101716

17 October 2016

In patients with Parkinson’s disease (PD), hyperactivated inflammation in the brain, particularly microglial hyperactivation in the substantia nigra (SN), is reported to be one of the triggers for the delayed loss of dopaminergic neurons and sequenti...

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Article

5 Citations

2,185 Views

14 Pages

Protection of Mitochondrial Potential and Activity by Oxyprenylated Phenylpropanoids

Francesco Epifano,
Salvatore Genovese,
Lucia Palumbo,
Chiara Collevecchio and
Serena Fiorito

Antioxidants2023, 12(2), 259;https://doi.org/10.3390/antiox12020259

23 January 2023

A series of five naturally occurring oxyprenylated phenylpropanoids, namely, the coumarins auraptene (7-geranyloxycoumarin) 1 and 7-isopentenyloxycoumarin 2, and the coumaric acid and ferulic acid derivatives, 4’-isopentenyloxycoumaric acid 3,...

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