2 Results Found

Advanced Search

Select all

Results per page

Select all

Article

2 Citations

3,592 Views

10 Pages

(+)-Spectaline and Iso-6-Spectaline Induce a Possible Cross-Talk between Autophagy and Apoptosis in Trypanosoma brucei rhodesiense

Kah Tee Lim,
Chiann Ying Yeoh,
Zafarina Zainuddin and
Mohd. Ilham Adenan

Trop. Med. Infect. Dis.2019, 4(3), 98;https://doi.org/10.3390/tropicalmed4030098

-

1 July 2019

In our previous study, two known piperidine alkaloids (+)-spectaline (1) and iso-6-spectaline (2) were isolated from the leaves of Senna spectabilis and showed no toxic effect on L6 cells. In view of the potential use of piperidine alkaloids in S. sp...

Full Article

Article

1 Citations

3,335 Views

21 Pages

Synthesis and Anticholinesterase Evaluation of Cassine, Spectaline and Analogues

Marcela C. R. Silva,
Adriana F. L. Vilela,
Carmen L. Cardoso and
Ronaldo A. Pilli

Sci. Pharm.2022, 90(4), 63;https://doi.org/10.3390/scipharm90040063

-

13 October 2022

In this work, twelve analogues of piperidine alkaloids (-)-cassine and (-)-spectaline were synthesized, as well as the racemic forms of these natural products. The compounds were evaluated for their inhibition of electric eel acetylcholinesterase (AC...

Full Article