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Biomolecules | Highly Viewed Papers and Hot Topic Special Issues on Cellular Biochemistry

Biomolecules | Highly Viewed Papers and Hot Topic Special Issues on Cellular Biochemistry

9 December 2025


We are delighted to share a collection of highly viewed papers and successful Special Issues on cellular biochemistry that were published in Biomolecules (ISSN: 2218-273X) in 2025. The following is a list of articles and Special Issues that we believe may be of interest to you:

Articles:

“HBV cccDNA: The Molecular Reservoir of Hepatitis B Persistence and Challenges to Achieve Viral Eradication”
by André Boonstra and Gulce Sari
Biomolecules 2025, 15(1), 62; https://doi.org/10.3390/biom15010062
Available online: https://www.mdpi.com/2218-273X/15/1/62

“G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential”
by Yun Yeong Cho, Soyeon Kim, Pankyung Kim, Min Jeong Jo, Song-E Park, Yiju Choi, Su Myung Jung and Hye Jin Kang
Biomolecules 2025, 15(2), 291; https://doi.org/10.3390/biom15020291
Available online: https://www.mdpi.com/2218-273X/15/2/291

“Not Just an Alternative Energy Source: Diverse Biological Functions of Ketone Bodies and Relevance of HMGCS2 to Health and Disease”
by Varshini V. Suresh, Sathish Sivaprakasam, Yangzom D. Bhutia, Puttur D. Prasad, Muthusamy Thangaraju and Vadivel Ganapathy
Biomolecules 2025, 15(4), 580; https://doi.org/10.3390/biom15040580
Available online: https://www.mdpi.com/2218-273X/15/4/580

“Therapeutic Plasma Exchange: Current and Emerging Applications to Mitigate Cellular Signaling in Disease”
by R. M. Imtiaz Karim Rony, Alireza Shokrani, Naseeb Kaur Malhi, Deborah Hussey, Rachael Mooney, Zhen Bouman Chen, Tristan Scott, Haiyong Han, Jaeger Moore, Jiahui Liu et al.
Biomolecules 2025, 15(7), 1000; https://doi.org/10.3390/biom15071000
Available online: https://www.mdpi.com/2218-273X/15/7/1000

“State of the Art in the Standardization of Stromal Vascular Fraction Processing”
by Martina Cremona, Matteo Gallazzi, Giulio Rusconi, Luca Mariotta, Mauro Gola and Gianni Soldati
Biomolecules 2025, 15(2), 199; https://doi.org/10.3390/biom15020199
Available online: https://www.mdpi.com/2218-273X/15/2/199

“Carnitine O-Acetyltransferase as a Central Player in Lipid and Branched-Chain Amino Acid Metabolism, Epigenetics, Cell Plasticity, and Organelle Function”
by Mariateresa Volpicella, Maria Noemi Sgobba, Luna Laera, Anna Lucia Francavilla, Danila Imperia De Luca, Lorenzo Guerra, Ciro Leonardo Pierri and Anna De Grassi
Biomolecules 2025, 15(2), 216; https://doi.org/10.3390/biom15020216
Available online: https://www.mdpi.com/2218-273X/15/2/216

“Early-Stage Luminal B-like Breast Cancer Exhibits a More Immunosuppressive Tumor Microenvironment than Luminal A-like Breast Cancer”
by Tânia Moura, Olga Caramelo, Isabel Silva, Sandra Silva, Manuela Gonçalo, Maria Antónia Portilha, João N. Moreira, Ana M. Gil, Paula Laranjeira and Artur Paiva
Biomolecules 2025, 15(1), 78; https://doi.org/10.3390/biom15010078
Available online: https://www.mdpi.com/2218-273X/15/1/78

“Retinal Pigment Epithelium Transplantation in Retinal Disease: Clinical Trial Development, Challenges, and Future Directions”
by Qin Chen, Ting Zhang, Zhi Chen, Jingwen Zeng, Aine O’Connor, Meidong Zhu, Mark C. Gillies, Fang Lu and Ling Zhu
Biomolecules 2025, 15(8), 1167; https://doi.org/10.3390/biom15081167
Available online: https://www.mdpi.com/2218-273X/15/8/1167

“Mechanobiology in Action: Biomaterials, Devices, and the Cellular Machinery of Force Sensing”
by Miriam Lucariello, Maria Luisa Valicenti, Samuele Giannoni, Leonardo Donati, Ilaria Armentano, Francesco Morena and Sabata Martino
Biomolecules 2025, 15(6), 848; https://doi.org/10.3390/biom15060848
Available online: https://www.mdpi.com/2218-273X/15/6/848

“The Role of Astrocytes in the Molecular Pathophysiology of Schizophrenia: Between Neurodevelopment and Neurodegeneration”
by Licia Vellucci, Benedetta Mazza, Annarita Barone, Anita Nasti, Giuseppe De Simone, Felice Iasevoli and Andrea de Bartolomeis
Biomolecules 2025, 15(5), 615; https://doi.org/10.3390/biom15050615
Available online: https://www.mdpi.com/2218-273X/15/5/615

Special Issues:

Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon
Guest Editors: Dr. Eun-Woo Lee and Dr. Hye Jin Kang
Published papers: 11
Viewed by 30345+

The Central Role of Mitochondrial Protein VDAC1 in Human Diseases – Honorary Special Issue Commemorating the Work of Prof. Varda Shoshan-Barmatz
Guest Editor: Dr. Jay H. Chung
Published papers: 7
Viewed by 25620+

Effects of Weightlessness on Molecular Changes in Cellular Organisms, Animals and Plants
Guest Editor: Prof. Dr. Daniela Grimm
Published papers: 11
Viewed by 33645+

Recent Developments in Mesenchymal Stem Cells
Guest Editors: Dr. Antonietta Rosa Silini and Dr. Enrico Ragni
Published papers: 8
Viewed by 29955+

Feature Papers in Cellular Biochemistry
Guest Editor: Prof. Dr. Anna Rita Franco Migliaccio
Published papers: 9
Viewed by 24780+

Advances in Cellular and Molecular Mechanisms in Immuno-Oncology and Onco-Hematology
Guest Editor: Dr. Paolo Fagone
Published papers: 9
Viewed by 23480+

Microbial Biocontrol and Plant-Microbe Interactions
Guest Editor: Dr. Shahzad Munir
Published papers: 7
Viewed by 9060+

Advances in Metal Binding Proteins
Guest Editor: Dr. Eugene Permyakov
Published papers: 11
Viewed by 45435+