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Special Issue "T Cell-Mediated Antiviral Immunity"
Deadline for manuscript submissions: 31 December 2019.
Pattern recognition receptor signalling (TLRs, RLRs, CLRs, and NLRs) can recognize viral pathogen associated molecular patterns and can trigger a robust type-I interferon (IFN) and pro-inflammatory cytokine response that functions to control virus replication and limit spread within a host. Antigen presenting cells (e.g., dendritic cells) provide a critical link between these innate immune signals and priming T-cell responses that function to clear virus infection and provide protection against re-infection. Over the past 20 years, there have been tremendous research efforts to understand the underlying mechanisms that regulate both dendritic cell responses and the development of effector and memory antiviral T-cell responses during virus infection. These efforts have culminated in identifying key transcription factors, signaling components, and cytokines that ultimately determine T-cell fate and function. Recent technological advances and the use of integrated multi-omics-based approaches (e.g., epigenomic, transcriptomic, proteomic, metabolomic, and lipidomic) are providing an unprecedented and global assessment of T-cell responses during virus infection. In this Special Issue, we will focus on the recent discoveries related to the mechanisms and pathways that determine T-cell fate and function, control T-cell exhaustion, promote tissue-resident memory T-cell responses, and promote viral clearance during virus infection. We will also highlight recent efforts to develop effective T cell-inducing vaccines against viral diseases.
Dr. Mehul Suthar
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tissue-resident memory T cells
- viral immunology
- intravital microscopy
- emgering viruses
- vaccine-induced T cell immunity
- regulatory T cells
- CD4+ T cells
- CD8+ T cells
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: To go or stay: the development, benefit, and detriment of tissue-resident memory CD8 T cells during central nervous system viral infections
Authors: Taryn Mockus, Heather Ren, Shwetank, Aron Lukacher