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To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections

1
Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
2
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
3
Biocon Bristol-Myers Squib Research and Development Center, Biocon Park, Bengaluru 560099, India
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(9), 842; https://doi.org/10.3390/v11090842
Received: 19 July 2019 / Revised: 30 August 2019 / Accepted: 6 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue T Cell-Mediated Antiviral Immunity)
CD8 T cells coordinate immune defenses against viral infections of the central nervous system (CNS). Virus-specific CD8 T cells infiltrate the CNS and differentiate into brain-resident memory CD8 T cells (CD8 bTRM). CD8 bTRM are characterized by a lack of recirculation and expression of phenotypes and transcriptomes distinct from other CD8 T cell memory subsets. CD8 bTRM have been shown to provide durable, autonomous protection against viral reinfection and the resurgence of latent viral infections. CD8 T cells have also been implicated in the development of neural damage following viral infection, which demonstrates that the infiltration of CD8 T cells into the brain can also be pathogenic. In this review, we will explore the residency and maintenance requirements for CD8 bTRM and discuss their roles in controlling viral infections of the brain. View Full-Text
Keywords: CD8 T cells; resident memory T cells; viral infection; central nervous system CD8 T cells; resident memory T cells; viral infection; central nervous system
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Mockus, T.E.; Ren, H.M.; Shwetank; Lukacher, A.E. To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections. Viruses 2019, 11, 842.

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