Next Article in Journal
An Update on Innate Immune Responses during SARS-CoV-2 Infection
Previous Article in Journal
Metabolic Reprogramming of Nasal Airway Epithelial Cells Following Infant Respiratory Syncytial Virus Infection
Article

Lower Respiratory Tract Infection and Genus Enterovirus in Children Requiring Intensive Care: Clinical Manifestations and Impact of Viral Co-Infections

1
Paediatrics Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
2
Paediatrics Intensive Care Unit, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
3
Enterovirus and Viral Gastroenteritis Unit, Centro Nacional de Microbiología, Instituto Carlos III, 28222 Madrid, Spain
4
Grupo de Investigación en Enfermedades Infecciosas Pediátricas, Institut de Recerca Sant Joan de Déu, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
5
Molecular Microbiology Department, Hospital Sant Joan de Déu, 08195 Barcelona, Spain
6
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
7
Paediatrics Department, Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08007 Barcelona, Spain
8
Department of Medicine, School of Medicine, Universitat Internacional de Catalunya, 08017 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Kelvin Kai-Wang To
Viruses 2021, 13(10), 2059; https://doi.org/10.3390/v13102059
Received: 11 August 2021 / Revised: 7 October 2021 / Accepted: 8 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Respiratory Viral Coinfection)
Infection by rhinovirus (RV) and enterovirus (EV) in children ranges from asymptomatic infection to severe lower respiratory tract infection (LRTI). This cohort study evaluates the clinical impact of RV/EV species, alone or in codetection with other viruses, in young children with severe LRTI. Seventy-one patients aged less than 5 years and admitted to the Paediatric Intensive Care Unit (PICU) of a reference children’s hospital with RV or EV (RV/EV) LRTI were prospectively included from 1/2018 to 3/2020. A commercial PCR assay for multiple respiratory pathogens was performed in respiratory specimens. In 22/71, RV/EV + respiratory syncytial virus (RSV) was found, and 18/71 had RV/EV + multiple viral detections. Patients with single RV/EV detection required invasive mechanical ventilation (IMV) as frequently as those with RSV codetection, whereas none of those with multiple viral codetections required IMV. Species were determined in 60 samples, 58 being RV. No EV-A, EV-C, or EV-D68 were detected. RV-B and EV-B were only found in patients with other respiratory virus codetections. There were not any associations between RV/EV species and severity outcomes. To conclude, RV/EV detection alone was observed in young children with severe disease, while multiple viral codetections may result in reduced clinical severity. Differences in pathogenicity between RV and EV species could not be drawn. View Full-Text
Keywords: rhinovirus; enterovirus; co-infection; intensive care units; child; lower respiratory tract infection rhinovirus; enterovirus; co-infection; intensive care units; child; lower respiratory tract infection
Show Figures

Figure 1

MDPI and ACS Style

Penela-Sánchez, D.; González-de-Audicana, J.; Armero, G.; Henares, D.; Esteva, C.; de-Sevilla, M.-F.; Ricart, S.; Jordan, I.; Brotons, P.; Cabrerizo, M.; Muñoz-Almagro, C.; Launes, C. Lower Respiratory Tract Infection and Genus Enterovirus in Children Requiring Intensive Care: Clinical Manifestations and Impact of Viral Co-Infections. Viruses 2021, 13, 2059. https://doi.org/10.3390/v13102059

AMA Style

Penela-Sánchez D, González-de-Audicana J, Armero G, Henares D, Esteva C, de-Sevilla M-F, Ricart S, Jordan I, Brotons P, Cabrerizo M, Muñoz-Almagro C, Launes C. Lower Respiratory Tract Infection and Genus Enterovirus in Children Requiring Intensive Care: Clinical Manifestations and Impact of Viral Co-Infections. Viruses. 2021; 13(10):2059. https://doi.org/10.3390/v13102059

Chicago/Turabian Style

Penela-Sánchez, Daniel, Jon González-de-Audicana, Georgina Armero, Desiree Henares, Cristina Esteva, Mariona-Fernández de-Sevilla, Silvia Ricart, Iolanda Jordan, Pedro Brotons, María Cabrerizo, Carmen Muñoz-Almagro, and Cristian Launes. 2021. "Lower Respiratory Tract Infection and Genus Enterovirus in Children Requiring Intensive Care: Clinical Manifestations and Impact of Viral Co-Infections" Viruses 13, no. 10: 2059. https://doi.org/10.3390/v13102059

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop