Special Issue "Reoviruses"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editors

Dr. Pranav Danthi
Guest Editor
Department of Biology, Indiana University, Bloomington, IN, USA
Interests: reovirus entry; host responses and cell death
Dr. Maya Shmulevitz
Guest Editor
Department of Medical Microbiology and Immunology, Li Ka Shing Institute for Virology, University of Alberta, Edmonton, Alberta, Canada
Interests: reoviridae; virus adaptation; oncolytic viruses; protein structure-function relationships; virus assembly; cell signalling in response to virus

Special Issue Information

Dear Colleagues,

Since the fortuitous discovery of reoviruses in the 1950s, these dsRNA icosahedral members of the Reoviridae family have served to understand countless concepts in cell biology, virology, and virus–host interactions in vitro, cell cultures, and animal models. Among the many molecular contributions, research on reoviruses facilitated the discovery of mRNA capping, and the realization that non-enveloped viruses can also encode membrane fusogenic proteins, thus understanding the virus structure, mechanisms of cell attachment, and virus entry. Recent advances in high resolution virus structure determination show remarkable routes of capsid evolution among members of the Reoviridae. In vivo, reoviruses serve as powerful model systems for a better understanding antiviral signaling and virus-induced disease pathogenesis. Most recently, reoviruses provide insight into gut microbe interactions between viruses and bacteria. Reoviruses, as well as reovirus-derived fusogenic proteins, are also being developed into cancer therapies.

Reoviridae diverged into the sedoreovirinae (nonturreted) and spinareovirinae (turreted) subfamilies; each subfamily containing virus members that are pathogenic, or potential tools for beneficial application. Although the reovirus designation generally refers to the orthoreovirus genus, this Special Issue is designed to provide an up-to-date view of the spinareovirinae subfamily in general. With shared evolution, each genus of spinareovirinae offers a strategy to better understand, control, or exploit this subfamily of viruses. This Special Issue invites both general updating reviews on aquareoviruses, coltiviruses, cypoviruses, fijiviruses, orthoreoviruses, idnoreoviruses, dinovernaviruses, oryzaviruses, and mycoreoviruses, as well as reviews and original research articles on specific topics such as evolution, structure–function of specific spinareovirinae proteins, or host–pathogen interactions.

Dr. Pranav Danthi
Dr. Maya Shmulevitz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Aquareoviruses
  • Coltiviruses
  • Cypoviruses
  • Fijiviruses
  • Orthoreoviruses
  • Idnoreoviruses
  • Dinovernaviruses
  • Oryzaviruses
  • mycoreoviruses
  • virus attachment
  • virus entry
  • replication mechanisms
  • pathogenesis
  • innate immune responses
  • oncolytics
  • reverse genetics
  • virus structure
  • evolution

Published Papers (1 paper)

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Open AccessArticle
Unexpected Genetic Diversity of Two Novel Swine MRVs in Italy
Viruses 2020, 12(5), 574; https://doi.org/10.3390/v12050574 - 22 May 2020
Mammalian Orthoreoviruses (MRV) are segmented dsRNA viruses in the family Reoviridae. MRVs infect mammals and cause asymptomatic respiratory, gastro-enteric and, rarely, encephalic infections. MRVs are divided into at least three serotypes: MRV1, MRV2 and MRV3. In Europe, swine MRV (swMRV) was first [...] Read more.
Mammalian Orthoreoviruses (MRV) are segmented dsRNA viruses in the family Reoviridae. MRVs infect mammals and cause asymptomatic respiratory, gastro-enteric and, rarely, encephalic infections. MRVs are divided into at least three serotypes: MRV1, MRV2 and MRV3. In Europe, swine MRV (swMRV) was first isolated in Austria in 1998 and subsequently reported more than fifteen years later in Italy. In the present study, we characterized two novel reassortant swMRVs identified in one same Italian farm over two years. The two viruses shared the same genetic backbone but showed evidence of reassortment in the S1, S4, M2 segments and were therefore classified into two serotypes: MRV3 in 2016 and MRV2 in 2018. A genetic relation to pig, bat and human MRVs and other unknown sources was identified. A considerable genetic diversity was observed in the Italian MRV3 and MRV2 compared to other available swMRVs. The S1 protein presented unique amino acid signatures in both swMRVs, with unexpected frequencies for MRV2. The remaining genes formed distinct and novel genetic groups that revealed a geographically related evolution of swMRVs in Italy. This is the first report of the complete molecular characterization of novel reassortant swMRVs in Italy and Europe, which suggests a greater genetic diversity of swMRVs never identified before. Full article
(This article belongs to the Special Issue Reoviruses)
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