RNA Interference (RNAi) for Antiviral Therapy
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 24884
Special Issue Editor
Interests: viral gene therapy; viral vaccines; gene expression using viral vectors; structural biology; epigenetics; nutrigenomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The discovery of RNA interference (RNAi) has opened up completely new possibilities in research and therapeutic applications. In this context, small interfering RNAs (siRNAs) and micro-RNAs (miRNAs) are of particular interest. The attraction of therapeutic RNAi relates to its reversible nature, whereby an effective gene silencing the targeted RNA is degraded by a sequence-specific process, leaving no risk of prolonged effect after the termination of treatment. The delivery of RNAi has been considered to be one of the major obstacles for therapeutic efficacy and safety. For this reason, both non-viral and viral delivery methods for RNAi have been developed. The global threat of emerging lethal viral infectious diseases reaching epidemic levels has triggered the development of RNAi-based therapeutics. For example, RNAi approaches have been executed or planned for influenza virus, human immunodeficiency virus (HIV), hepatitis virus, Ebola virus, and Dengue virus. Clinical trials have been conducted for respiratory syncytial virus (RSV), hepatitis B virus (HBV), HIV, and Ebola virus. This Special Issue on RNAi for Antiviral Therapy aims at reviewing the recent progress in the field, from vector engineering and delivery technologies to clinical trials.
Dr. Kenneth Lundstrom
Guest Editor
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Keywords
- target identification
- vector engineering
- delivery
- preclinical studies
- clinical trials
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