Gene Therapy

Dear Colleagues,

It is my great pleasure to introduce the Special Issue on “Gene Therapy”. In the 1990s, gene therapy was considered most promising and the perfect technology to develop medicines of the future. Inexperience and unfortunate circumstances led to some severe setbacks in conducted clinical trials, which put gene therapy development on hold for some time. Luckily, during this delay much attention was paid to gene therapy vector engineering, improvement of safety standards and refinements in the design of clinical trials, which has contributed to the renaissance of gene therapy. Today, an increasing number of clinical trials are in progress and several gene therapy-based drugs have been approved. It is therefore most appropriate to share the latest development with the scientific community in this special issue. As you will notice, the articles cover engineering of non-viral and viral vectors, gene therapy applications for various indications, such as cancer, hemophilia, AIDS, severe combined immunodeficiency and neurological diseases. Moreover immunotherapy, which has received a lot of attention recently, is presented in detail.

Dr. Kenneth Lundstrom
Guest Editor

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