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Editorial

Are Viral Vectors Any Good for RNAi Antiviral Therapy?

PanTherapeutics, Route de Lavaux 49, CH1095 Lutry, Switzerland
Editorial to Special Issue RNA Interference (RNAi) for Antiviral Therapy.
Viruses 2020, 12(10), 1189; https://doi.org/10.3390/v12101189
Received: 15 October 2020 / Accepted: 19 October 2020 / Published: 20 October 2020
(This article belongs to the Special Issue RNA Interference (RNAi) for Antiviral Therapy)
RNA interference (RNAi) represents a novel approach for alternative antiviral therapy. However, issues related to RNA delivery and stability have presented serious obstacles for obtaining good therapeutic efficacy. Viral vectors are capable of efficient delivery of RNAi as short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA). Efficacy in gene silencing for therapeutic applications against viral diseases has been demonstrated in various animal models. Rotavirus (RV) miR-7 can inhibit rotavirus replication by targeting the RV nonstructural protein 5. Viral gene silencing by targeting the RNAi pathway showed efficient suppression of hepatitis B virus replication by adeno-associated virus (AAV)-based delivery of RNAi hepatitis B virus (HBV) cassettes. Hepatitis C virus replication has been targeted by short hairpin RNA molecules expressed from lentivirus vectors. Potentially, RNAi-based approaches could be suitable for antiviral drugs against COVID-19. View Full-Text
Keywords: gene silencing; RNAi; shRNA; miRNA; viral vector; viral replication; antiviral drugs; COVID-19 gene silencing; RNAi; shRNA; miRNA; viral vector; viral replication; antiviral drugs; COVID-19
MDPI and ACS Style

Lundstrom, K. Are Viral Vectors Any Good for RNAi Antiviral Therapy? Viruses 2020, 12, 1189. https://doi.org/10.3390/v12101189

AMA Style

Lundstrom K. Are Viral Vectors Any Good for RNAi Antiviral Therapy? Viruses. 2020; 12(10):1189. https://doi.org/10.3390/v12101189

Chicago/Turabian Style

Lundstrom, Kenneth. 2020. "Are Viral Vectors Any Good for RNAi Antiviral Therapy?" Viruses 12, no. 10: 1189. https://doi.org/10.3390/v12101189

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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