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Veterinary Sciences
Special Issues
Medical Interventions in Laboratory Animals
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Medical Interventions in Laboratory Animals

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1432

Special Issue Editors

Dr. Jaco Bakker

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Guest Editor
Animal Science Department, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands
Interests: veterinary; infectious diseases; medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Melissa De la Garza

E-Mail
Guest Editor
Department of Comparative Medicine, MD Anderson Cancer Center, Michale E. Keeling Center for Comparative Medicine and Research, Bastrop, TX 78602, USA
Interests: veterinary medicine; nonhuman primate care; animal welfare and behavior; lab animal science; diseases of laboratory animals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

“We don't have to change what works” is a common phrase that is used worldwide, including by dedicated laboratory animal specialists. In reality, there are still so many opportunities for the refinement of medical interventions, applied tasks, and tests, such as anesthetic procedures, forced swim tests, open-field tasks, euthanasia, and maintaining one’s body temperature during anesthesia. As all drugs are administrated off-label, the refinement of their dosage, routes of administration, and frequency is an easy-to-think-of area of improvement that would not only help the one administering the injections but also the animals being injected. Examples of this are the use of long-acting antibiotics, analgesics, or NSAIDs. However, we often fear change because the outcomes are unknown, hence the need to help each other by publishing our findings.

This Special Issue addresses the need to strengthen the flow and exchange of information between veterinary sciences through the publication of new or refined medical interventions, applied tasks, and tests for laboratory animals. This Special Issue will stimulate collaboration between the people involved in taking care of laboratory animals.

Dr. Jaco Bakker
Dr. Melissa De la Garza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • refinment
  • laboratory animals
  • medical interventions
  • surgery
  • medicine
  • behavioral tests
  • wellbeing
  • severity assessment

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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11 pages, 3208 KiB  
Case Report
Progressive Evaluation of Ischemic Occlusion in a Macaque Monkey with Sudden Exacerbation of Infarction During Acute Stroke: A Case Report
by Chun-Xia Li and Xiaodong Zhang
Vet. Sci. 2025, 12(3), 231; https://doi.org/10.3390/vetsci12030231 - 3 Mar 2025
Viewed by 495
Abstract
Early neurological deterioration is associated with poor functional outcomes in stroke patients, but the underlying mechanisms remain unclear. This study aims to understand the progression of stroke-related brain damage using a rhesus monkey model with ischemic occlusion. Multiparameter MRI was used to monitor [...] Read more.
Early neurological deterioration is associated with poor functional outcomes in stroke patients, but the underlying mechanisms remain unclear. This study aims to understand the progression of stroke-related brain damage using a rhesus monkey model with ischemic occlusion. Multiparameter MRI was used to monitor the progressive evolution of the brain lesion following stroke. Resting-state functional MRI, dynamic susceptibility contrast perfusion MRI, diffusion tensor imaging, and T1- and T2-weighted scans were acquired prior to surgery and at 4–6 h, 48 h, and 96 h following the stroke. The results revealed a sudden increase in infarction volume after the hyper-acute phase but before 48 h on diffusion-weighted imaging (DWI), with a slight extension by 96 h. Lower relative cerebral blood flow (CBF) and time to maximum (Tmax) prior to the stroke, along with a progressive decrease post-stroke, were observed when compared to other stroke monkeys in the same cohort. Functional connectivity (FC) in the ipsilesional secondary somatosensory cortex (S2) and primary motor cortex (M1) exhibited an immediate decline on Day 0 compared to baseline and followed by a slight increase on Day 2 and a further decrease on Day 4. These findings provide valuable insights into infarction progression, emphasizing the critical role of collateral circulation and its impact on early neurological deterioration during acute stroke. Full article
(This article belongs to the Special Issue Medical Interventions in Laboratory Animals)
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