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Veterinary Sciences
Special Issues
Nutritional Regulation and Intestinal Health in Piglets
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Nutritional Regulation and Intestinal Health in Piglets

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1483

Special Issue Editors

Dr. Xingping Chen

E-Mail Website
Guest Editor
Jiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China
Interests: piglets nutrition and metabolism; intestinal development and health; none-coding RNAs; extra-cellular vesicles (EVs)
Dr. Jun Chen

E-Mail Website
Guest Editor
Jiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China
Interests: sow and piglet nutrition; antioxidants; oxidative stress; trace elements; plant-derived bioactive additives
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jinming You

E-Mail Website
Guest Editor
Jiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China
Interests: swine nutrition and metabolism; functional feed additives; intestinal development and health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As the main site of nutrients digestion and absorption and an important defense line against the invasion of bacteria and endotoxins into the intestinal lumen, the intestinal tract is an important organ in response to stress in piglets. In modern intensive large-scale swine production, piglets may encounter various external stress challenges, which include social factors like stocking density, feed-related factors such as mycotoxin contamination, environmental factors like weaning stress, heat stress, pathogenic factors including Escherichia coli infections, and others. Those challenges usually affect the intestinal health of piglets, eventually, lead to economic losses. Many nutritional strategies have been applied to improve intestinal health which could increase the survival rate and growth performance in piglets. Those strategies include but not limited to supplementation of functional feed additives, such as plant extract and essential oil, trace elements, antimicrobial peptides, short-chain fatty acids and functional amino acids and derivatives. This research topic will primarily focus on the innovative nutritional strategies to improve intestinal health in piglets. Additionally, researchers are encouraged to investigate the underlying mechanisms.

Dr. Xingping Chen
Dr. Jun Chen
Prof. Dr. Jinming You
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intestinal health
  • stress challenges
  • nutritional strategies
  • functional feed additives
  • piglet growth performance

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Published Papers (3 papers)

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Research

18 pages, 7959 KiB  
Article
Pulsatilla Powder Ameliorates Damp-Heat Diarrhea in Piglets Through the Regulation of Intestinal Mucosal Barrier and the Pentose Phosphate Pathway Involving G6PD and NOX
by Yunqi Qu, Qi Ma, Chenying Wang, Lifang Zhang, Haolian Feng and Siyue Lai
Vet. Sci. 2025, 12(5), 403; https://doi.org/10.3390/vetsci12050403 - 25 Apr 2025
Viewed by 238
Abstract
Damp-heat diarrhea (DHD) in piglets presents as diarrhea and intestinal bleeding, significantly affecting both piglet health and the pig industry. Pulsatilla powder (PP), a herbal formulation composed of Pulsatilla, Rhizoma Coptidis, Phellodendron Bark, and Fraxini Cortex, has proven to be an effective treatment [...] Read more.
Damp-heat diarrhea (DHD) in piglets presents as diarrhea and intestinal bleeding, significantly affecting both piglet health and the pig industry. Pulsatilla powder (PP), a herbal formulation composed of Pulsatilla, Rhizoma Coptidis, Phellodendron Bark, and Fraxini Cortex, has proven to be an effective treatment for DHD. Although the pentose phosphate pathway (PPP) has been associated with its therapeutic effects, the exact mechanism of action remains unclear. In this study, the DHD model in piglets was established to evaluate clinical symptoms, organ index, serum index, histological changes, colonic metabolites, and molecular mechanisms using techniques such as QPCR, ELISA, WB and metabolomics. PP improved intestinal health by restoring spleen and lung index, increasing LDL-C and HDL-C levels (HDL-C: p < 0.05), decreasing mRNA expression levels of IFN-γ and TNF-α mRNA (p < 0.01), and increasing MUC1 and MUC2 expression. Metabolomics analysis has identified 44 pathways, including pentose phosphate and glutathione pathways, and 132 differential metabolites have involved in DHD treatment. PP significantly reduced G6PD (p < 0.01), inhibited the pentose phosphate pathway, reduced NOX production (p < 0.01), and suppressed ROS production (p < 0.01). These effects alleviated oxidative stress and intestinal damage, demonstrating PP’s effectiveness in treating DHD by targeting critical enzymes and ROS levels. Full article
(This article belongs to the Special Issue Nutritional Regulation and Intestinal Health in Piglets)
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19 pages, 4887 KiB  
Article
Dietary Angelica sinensis Enhances Sow Lactation and Piglet Development Through Gut Microbiota and Metabolism
by Qian Chen, Yali Song, Qitian Wu, Yali Wu, Maocuo Zhou, Yifei Ren, Xiaohong Guo, Guoqing Cao, Bugao Li, Zhibian Duan and Pengfei Gao
Vet. Sci. 2025, 12(4), 370; https://doi.org/10.3390/vetsci12040370 - 15 Apr 2025
Viewed by 335
Abstract
Piglets weaned per sow per year (PSY) is a crucial metric for assessing the reproductive performances of sows and directly affects both sow productivity and the economic profitability of pig farms [...] Full article
(This article belongs to the Special Issue Nutritional Regulation and Intestinal Health in Piglets)
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12 pages, 778 KiB  
Article
Effects of Dietary Mallotus oblongifolius Ultrafine Powder Supplementation on Quality of Pork from Hainan Pigs During the Late Fattening Period
by Yali Xie, Jilun Meng, Ruiping Sun, Jie Liu, Quanwei Liu, Yangkun Ou, Qi Qi, Xiang Li, Yan Zhang, Jingli Yuan, Manping Xing, Zhe Chao, Guiping Zhao and Limin Wei
Vet. Sci. 2025, 12(2), 173; https://doi.org/10.3390/vetsci12020173 - 14 Feb 2025
Viewed by 546
Abstract
The genus Mallotus oblongifolius (MO), a member of the Euphorbia family, exhibits a predominant distribution in Hainan Island and has been proven to possess diverse medicinal attributes. Research indicates that ultramicro-grinding fully exposes the active ingredients of Mallotus oblongifolius, enhancing bioavailability and [...] Read more.
The genus Mallotus oblongifolius (MO), a member of the Euphorbia family, exhibits a predominant distribution in Hainan Island and has been proven to possess diverse medicinal attributes. Research indicates that ultramicro-grinding fully exposes the active ingredients of Mallotus oblongifolius, enhancing bioavailability and efficacy, compared to before. Our study investigates the effects of ultrafine powder of Mallotus oblongifolius (MOUP) on Hainan pigs. A total of sixty-four healthy castrated pigs (ternary hybrid pigs, Duroc × Duroc × Tunchang) with comparable initial body weight (BW, 68.06 ± 1.03 kg, 150 days old) were allocated randomly into four groups: the control group (CONT), the antibiotic group (ANTI), the 0.1% MOUP group (PT1), and the 0.5% MOUP group (PT2). There were four replicate pens per treatment with four pigs per pen. The pre-test lasted for 7 days and the formal test lasted for 70 days. The CONT group was fed the basal diet, the ANTI group was fed the basal diet supplemented with 300 mg/kg colistin sulfate, the PT1 group was fed the basal diet supplemented with 0.1% MOUP, and the PT2 group was fed the basal diet supplemented with 0.5% MOUP. The findings of our study indicate that the inclusion of colistin sulfate and MOUP in the diet did not have any significant impact on the production performance or carcass indicators of Hainan pigs compared to the CONT group. However, it is noteworthy that the addition of MOUP to the diet resulted in a significant improvement in the lightness, tenderness, muscle fiber morphology, amino acid composition, and antioxidant activity of the longissimus dorsi muscle, particularly in the PT2 group, compared to the CONT group. In conclusion, the present study has demonstrated that the inclusion of MOUP in the dietary regimen yields enhancements in the meat quality of Hainan pigs, particularly when supplemented at a concentration of 0.5%. Full article
(This article belongs to the Special Issue Nutritional Regulation and Intestinal Health in Piglets)
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