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Veterinary Sciences
Special Issues
Advances in Canine and Feline Lymphoma
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Advances in Canine and Feline Lymphoma

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 6914

Special Issue Editor

Dr. Fulvio Riondato

E-Mail Website
Guest Editor
Department of Veterinary Sciences, University of Torino, 10095 Grulgiasco (TO), Italy
Interests: flow cytometry; hematology; cytology; lymphoma; leukemia

Special Issue Information

Dear Colleagues,

I'm pleased to invite you to contribute to the special Issue on “Advances in Canine and Feline Lymphoma”. Lymphoma in dogs and cats has become a daily challenge for oncologists and clinicians. Research and publications in recent years have allowed for a greater characterization of the different biological entities included under the definition of lymphoma. Laboratory analyses have played an important role, but the usefulness of an integrated approach between different competences (clinician, radiologist, pathologist, clinical pathologist, geneticist, etc.) and the need to deepen the knowledge in a multidisciplinary way have become clear. This is especially true for the dog, for whom the acquired knowledge has led to its recognition as a possible spontaneous animal model for the human counterpart. Much of this work is still to be addressed for feline lymphomas, whose peculiarities place greater limits both to clinicians and researchers. Many aspects remain to be clarified or explored both in canine and feline lymphomas and the need for more (and more specific) diagnostic and prognostic laboratory tests as well as for a greater effort to discover new potential target for therapy is emerging. This special issue is intended as a collection point for the most recent advances in feline and canine lymphoma in the fields of pathogenesis, biology, clinical-pathology, diagnosis, prognosis and therapy, with particular focus on the significance of laboratory analyses (from cytology to molecular biology). Original research articles, short communications, technical notes, as well as reviews are welcome.

I look forward to receiving your contributions.

Dr. Fulvio Riondato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lymphoma
  • cat
  • dog
  • diagnosis
  • prognosis
  • therapy

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Published Papers (2 papers)

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Research

32 pages, 9199 KiB  
Article
Lymphoma in Border Collies: Genome-Wide Association and Pedigree Analysis
by Pamela Xing Yi Soh, Mehar Singh Khatkar and Peter Williamson
Vet. Sci. 2023, 10(9), 581; https://doi.org/10.3390/vetsci10090581 - 19 Sep 2023
Cited by 1 | Viewed by 3862
Abstract
There has been considerable interest in studying cancer in dogs and its potential as a model system for humans. One area of research has been the search for genetic risk variants in canine lymphoma, which is amongst the most common canine cancers. Previous [...] Read more.
There has been considerable interest in studying cancer in dogs and its potential as a model system for humans. One area of research has been the search for genetic risk variants in canine lymphoma, which is amongst the most common canine cancers. Previous studies have focused on a limited number of breeds, but none have included Border Collies. The aims of this study were to identify relationships between Border Collie lymphoma cases through an extensive pedigree investigation and to utilise relationship information to conduct genome-wide association study (GWAS) analyses to identify risk regions associated with lymphoma. The expanded pedigree analysis included 83,000 Border Collies, with 71 identified lymphoma cases. The analysis identified affected close relatives, and a common ancestor was identified for 54 cases. For the genomic study, a GWAS was designed to incorporate lymphoma cases, putative “carriers”, and controls. A case-control GWAS was also conducted as a comparison. Both analyses showed significant SNPs in regions on chromosomes 18 and 27. Putative top candidate genes from these regions included DLA-79, WNT10B, LMBR1L, KMT2D, and CCNT1. Full article
(This article belongs to the Special Issue Advances in Canine and Feline Lymphoma)
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12 pages, 2015 KiB  
Article
Flow Cytometric Features of B- and T-Lmphocytes in Reactive Lymph Nodes Compared to Their Neoplastic Counterparts in Dogs
by Fulvio Riondato, Alessia Poggi, Barbara Miniscalco, Federica Sini, Laura Marconato and Valeria Martini
Vet. Sci. 2023, 10(6), 374; https://doi.org/10.3390/vetsci10060374 - 26 May 2023
Cited by 3 | Viewed by 2059
Abstract
An in-depth knowledge of non-neoplastic patterns is fundamental to diagnose neoplasia. In the present study, we described the flow cytometric (FC) cell size (FSC) and fluorescence intensity (MFI) of B- and T-lymphocytes in 42 canine reactive lymph nodes and 36 lymphomas. Proliferative activity [...] Read more.
An in-depth knowledge of non-neoplastic patterns is fundamental to diagnose neoplasia. In the present study, we described the flow cytometric (FC) cell size (FSC) and fluorescence intensity (MFI) of B- and T-lymphocytes in 42 canine reactive lymph nodes and 36 lymphomas. Proliferative activity (Ki67%) in reactive lymph nodes was also reported. Reactive lymph nodes were composed of a mixed population of small and large T (CD5+) and B (CD21+) cells. Small T-cells were larger in size than small B-cells, and large T-cells were larger than large B-cells. Small T-cells were composed of CD5+CD21− and CD5+CD21+dim subpopulations. Large B-cells were <20% in reactive lymph nodes and >20% in lymphomas and showed a higher FSC in lymphomas than in reactive lymph nodes. Large T-cells were <4% in reactive lymph nodes and >4% in lymphomas and showed a higher CD5 MFI in lymphomas (if expressed) compared to reactive lymph nodes. A subset of CD5+CD21+dim lymphocytes was recognized in addition to CD5+CD21- and CD5−CD21+ cells. In T-zone lymphomas, neoplastic cells had higher FSC and CD21 MFI values than small CD5+CD21+dim cells in reactive lymph nodes. Ki67% values were higher than those reported in normal lymph nodes, and largely overlapped with those reported in low-grade lymphomas and partially in high-grade lymphomas. Our results may contribute to making a less operator-dependent FC differential between lymphoma and reactive lymph nodes. Full article
(This article belongs to the Special Issue Advances in Canine and Feline Lymphoma)
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