Porcine Health Management: Virus Infection and Epidemic Disease

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 29 September 2026 | Viewed by 704

Special Issue Editors


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Guest Editor
Shandong Provincial Key Laboratory of Zoonoses, College of Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China
Interests: PRRSV-inactivated vaccine immune responses; swine disease; veterinary immunology and immunopathology; animal vaccines
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: PEDV; innate immune response; PDCoV; SVA; autophagy; IFN; animal vaccine

Special Issue Information

Dear Colleagues,

Porcine viral epidemics pose significant threats to global swine production, animal welfare, and food security. Effective health management centers on a multi-faceted biosecurity strategy. This includes strict isolation protocols, rigorous sanitation, controlled farm access, and vaccination programs where available. Critical diseases like African Swine Fever (ASF), Porcine Reproductive and Respiratory Syndrome (PRRS), and Porcine Epidemic Diarrhea (PED) require specific monitoring and containment measures. Early detection through vigilant surveillance and rapid diagnostic testing is essential for outbreak control. Ultimately, a proactive, prevention-focused approach integrating biosecurity, herd immunity management, and prompt response is fundamental to mitigating the economic and production impacts of these devastating viruses. We invite scientists to publish their research articles, short communications, or reviews to contribute further insight into the porcine health management.

Prof. Dr. Gang Wang
Dr. Ning Kong
Guest Editors

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Keywords

  • biosecurity
  • viral epidemics
  • swine viral pathogens
  • surveillance and detection
  • prevention and control
  • African swine fever virus (ASFV)
  • porcine reproductive and respiratory syndrome virus (PRRSV)
  • porcine epidemic diarrhea virus (PEDV)
  • porcine circovirus (PCV)
  • classical swine fever virus (CSFV)
  • foot and mouth disease virus (FMDV)
  • seneca A virus
  • porcine hemagglutinating encephalomyelitis virus (PHEV)
  • porcine rotavirus (PoRV)
  • porcine deltacoronavirus (PDCoV)

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Published Papers (1 paper)

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Research

14 pages, 6196 KB  
Article
Validation of Recombinant Type I Interferon Antiviral Activity Against Porcine Epidemic Diarrhea Virus In Vitro and In Vivo
by Luyu Du, Ruili Zhang, Shuyang Wang, Shanshan Han, Shuyu Zhang, Fanliang Meng, Zheng Fang, Xinyuan Wang, Rui Zhao, Ronglian Dai, Liting Qin, Chuang Lyu and Gang Wang
Vet. Sci. 2026, 13(3), 249; https://doi.org/10.3390/vetsci13030249 - 6 Mar 2026
Viewed by 429
Abstract
Porcine epidemic diarrhea virus (PEDV), a coronavirus responsible for severe watery diarrhea in neonatal piglets, leads to significant economic losses globally. Effective prevention and treatment of PEDV infection is critical to the swine industry. Currently, there are no available therapeutic drugs for PEDV. [...] Read more.
Porcine epidemic diarrhea virus (PEDV), a coronavirus responsible for severe watery diarrhea in neonatal piglets, leads to significant economic losses globally. Effective prevention and treatment of PEDV infection is critical to the swine industry. Currently, there are no available therapeutic drugs for PEDV. Porcine interferons (poIFNs) have been identified as promising molecules against a series of swine viruses due to their broad-spectrum antiviral and immunomodulatory properties. In this study, we demonstrated that type I interferon-α (IFN-α) offered both prophylactic and therapeutic benefits against PEDV infection. Recombinant poIFN-α produced by a prokaryotic expression system was purified through affinity chromatography, and its prophylactic and therapeutic effects against PEDV infection were evaluated in vitro and in vivo through RT-qPCR, clinical symptom monitoring, and pathological examination. In vitro studies revealed a strong antiviral activity of poIFN-α against PEDV in Vero E6 cells, with a more pronounced prophylactic effect compared to therapeutic outcomes. In vivo studies showed that poIFN-α significantly alleviated clinical diarrhea in PEDV-infected piglets and reduced intestinal viral loads. These findings suggest that poIFN-α holds considerable promise as an antiviral agent for PEDV and provides a foundation for the development of therapeutic strategies targeting this virus. Full article
(This article belongs to the Special Issue Porcine Health Management: Virus Infection and Epidemic Disease)
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