Autoimmune in Animal

Dear Collegaues,

Autoimmune diseases (AD) are self-directed inflammatory processes affecting one tenth of humanity. AD constitute a constellation of almost 100 conditions that can be organ-specific or systemic. Most AD are acquired and triggered by a variable combination of genetic and environmental factors, which conflate in disrupting immune homeostasis. Although much of the development and function of our immune system is understood, knowledge around the causes and pathophysiology of AD remains globally puzzling. This is due to the diversity and complexity of immune responses according to age, sex, tissue, or body offenders. Over the last century, we have learned with experimental medicine how to induce many of the major AD in animals, mimicking the clinical semiology of multiple sclerosis (MS), type 1 diabetes (T1D), or systemic lupus erythematous (SLE). These precious models have brought insight into the mechanisms of disease and have in occasions allowed us to improve therapies. In this Special Issue focusing on translational concepts, authors are invited to address the multiple pathways able to disrupt immune tolerance, exacerbate immune response, and restore immune homeostasis, as assessed in animal models of AD through the manipulation of their immune system.

Dr. Che Serguera
Guest Editor

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• immune tolerance
• inflammation
• self-antigen
• autoreactive lymphocytes
• auto-antibodies
• microbiome