Advances in Serologic Assays for Vaccination Monitoring and Assessment of Immune Protection
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: 31 May 2026 | Viewed by 10
Special Issue Editors
Interests: immunoassays; antibody testing; immunity to vaccine preventable diseases
Special Issue Information
Dear Colleagues,
Following vaccination, the first line of response is the ability to mount an antibody response. Thus, techniques such as the ELISA are often used to assess the level of antibodies. Other assays, such as the hemagglutination inhibition or plaque reduction neutralization assays, define the quality of antibodies produced. Other ways to monitor and assess correlates of immune protection, such as flow cytometry, are used for immune monitoring, enabling the phenotypic and functional characterization of immune cells. Additionally, other assays, such as the ELISpot assay, are used to detect antibody-secreting cells, and it is also used to evaluate IFN-γ production by T cells. It can be combined with intracellular cytokine staining to assess polyfunctional T cells.
Serosurveillance has been utilized to assess the level of protection from vaccine-preventable diseases (VPDs) within a population; however, this method has not been widely adopted, and existing surveillance studies typically focus on single infectious diseases. An integrated approach has been recommended as a more effective way to conduct serosurveillance for VPDs. New multiplex bead assays (MBA) have been developed to facilitate multi-VPD studies. MBAs and point-of-care tests could be helpful for individuals wishing to determine their susceptibility to VPDs. This information could help individuals make informed decisions about vaccination. Consequently, greater access to and availability of antibody testing may help bridge the gap between personal choice and public health needs.
Topics for the Special Issue include the following:
- Antibodies as markers of immunity to VPDs;
- Antibody tests for VPDs;
- Point-of-care tests for VPDs;
- Serosurveillance studies for VPDs.
Dr. Paul D. Olivo
Dr. Randolph F.R. Rasch
Guest Editors
Manuscript Submission Information
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Keywords
- vaccines
- vaccine-preventable diseases
- antibodies
- serology
- correlates of protection
- biomarkers of immunity
- immunosurveillance
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