Special Issue "Toxicokinetics and Toxicodynamics of Mycotoxins"
Deadline for manuscript submissions: 30 April 2021.
Interests: gut health; fusarium mycotoxins; interaction with bacterial enteric diseases
Special Issues and Collections in MDPI journals
The assessment of the risk for a given mycotoxin is based on risk characterization, combining three major pillars: hazard identification, hazard characterization, and exposure assessment. In this Special Issue we would like to focus on the first two pillars, aiming to identify and characterize the risk of a given mycotoxin by assessing both its toxicokinetics and its toxicity or toxicodynamics. Toxicokinetics include the so-called ADME processes (i.e., absorption, distribution, metabolism, and excretion), and determines the rate and extent at which the disposition of a toxin takes place. The toxicokinetic properties of a given toxin reflect its absolute internal dose, and comprise processes such as gastric and intestinal stability, rate and extent of oral absorption, presystemic elimination (first pass, metabolism in gut and/or liver), systemic elimination (metabolism and excretion) determining the total body clearance, and specific biological barriers determining the volume of distribution. Each of these processes may show species-specific differences. Next, toxicodynamics describe the toxicological characteristics (among others, cytotoxicity, genotoxicity (mutagenicity and carcinogenicity), mode of action, and dose–response relationship) of mycotoxins. Besides mycotoxin risk assessment, a toxicokinetic and toxicodynamic approach can also be applied to define the efficacy, mode of action, and safety of mycotoxin mitigation strategies.
This Special Issue aims to gather innovative research on toxicokinetics, toxicity, or toxicodynamics, and the integration of toxicokinetic and toxicodynamic processes of mycotoxins in animals and humans, such as papers describing the toxicokinetic properties of emerging mycotoxins, mycotoxin metabolites, or comparative inter-species approaches, as well as new approaches and alternatives for toxicity testing and toxicokinetic/toxicodynamic approaches to evaluating postharvest mycotoxin mitigation strategies.
Prof. Dr. Gunther Antonissen
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Mode of action