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Open AccessArticle

Calcination Improves the In Vivo Efficacy of a Montmorillonite Clay to Bind Aflatoxin G1 in Broiler Chickens: A Toxicokinetic Approach

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LR18AG01, ISA-CM-BP, 47, Institut Supérieur Agronomique de Chott-Mariem, Université de Sousse, 4042 Sousse, Tunisia
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Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
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Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
4
Research Laboratory LR18ES33, National Engineering School of Gabes, University of Gabes, Avenue Omar Ibn El Khattab, 6029 Gabes, Tunisia
*
Authors to whom correspondence should be addressed.
Toxins 2020, 12(10), 660; https://doi.org/10.3390/toxins12100660
Received: 2 September 2020 / Revised: 14 October 2020 / Accepted: 15 October 2020 / Published: 18 October 2020
(This article belongs to the Special Issue Toxicokinetics and Toxicodynamics of Mycotoxins)
The goal of this study was to investigate the toxicokinetic characteristics of aflatoxin G1 (AFG1) in broiler chickens and the effect of calcination of a Tunisian montmorillonite clay on the in vivo absorption of AFG1. In this study, broiler chickens were randomly distributed into four groups of 10 animals. Group 1 was administered AFG1 (2 mg/kg body weight (BW)) by single intravenous injection (IV), group 2 received an intra-crop bolus (PO) of AFG1 without any clay, group 3 was dosed AFG1 PO together with an oral bolus of purified clay (CP), and group 4 received AFG1 PO with an oral bolus of calcined clay. A significant difference in the area under the curve (AUC0-t) was observed for group 4 (6.78 ± 4.24 h*ng/mL) in comparison with group 2 (12.83 ± 4.19 h*ng/mL). A significant reduction of the oral bioavailability of AFG1 was observed for group 4 (7.61 ± 4.76%) compared with group 2 (14.40 ± 4.70%), while no significant effect was observed of CP. In this experiment, no phase I nor phase II metabolites of AFG1 were observed. These findings confirm that calcination of the purified montmorillonite clay enhances the adsorption of AFG1 in the gastrointestinal tract after oral administration, thereby reducing its bioavailability, thus reducing its toxic effects. View Full-Text
Keywords: AFG1; toxicokinetics; LC-MS/MS; LC-HRMS; calcination; montmorillonite clay; broiler chicken AFG1; toxicokinetics; LC-MS/MS; LC-HRMS; calcination; montmorillonite clay; broiler chicken
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MDPI and ACS Style

Rejeb, R.; Baere, S.D.; Devreese, M.; Ducatelle, R.; Croubels, S.; Ayed, M.H.; Ghorbal, A.; Antonissen, G. Calcination Improves the In Vivo Efficacy of a Montmorillonite Clay to Bind Aflatoxin G1 in Broiler Chickens: A Toxicokinetic Approach. Toxins 2020, 12, 660.

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