Uremic Toxins and Hemodialysis: Mechanisms, Challenges, and Therapeutic Advances
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: 31 March 2026 | Viewed by 80
Special Issue Editors
2. Nephrology & Dialysis Department, University Hospital Brugmann, Université Libre de Bruxelles, 4 Place Van Gehuchten, 1020 Brussels, Belgium
Interests: toxic nephropathies; renal fibrosis; end-stage kidney disease; renal replacement therapies; tubular and endothelial dysfunctions
Interests: uremic toxins; oxidative stress; renal cell cultures; tubulo–endothelial cell cross-talk
Special Issue Information
Dear Colleagues,
Hemodialysis (HD) is the world's most widely used renal replacement therapy for the management of end-stage kidney disease. Despite technological advances, plasma depuration performances remain limited and the accumulation of unremoved uremic toxins is still a major unsolved problem. In addition to the acute phase of potentially reversible renal damage, the transition to a chronic phase may be unavoidable. Moreover, because of the comorbidities frequently associated with advanced age (diabetes, hypertension, cardiovascular disease, overweight, dyslipidemia, smoking, etc.), access to transplantation will not be possible for the vast majority of patients worldwide.
Research is therefore still needed to better understand the key pathophysiological mechanisms behind the deleterious impact of uremic toxins on oxidative stress, endothelial dysfunction, and alterations to the microbiota, among other issues. Indeed, the therapeutic strategies depend on such research—whether they be medicinal or dietary, or combined with more sophisticated purification techniques. More than ever, an interdisciplinary approach to basic and clinical research on HD patients is crucial to improve the currently unfavorable overall prognosis linked to the numerous multi-systemic consequences.
This Special Issue aims to bring together as many varied contributions as possible in this field.
Prof. Dr. Joëlle Nortier
Prof. Dr. Marie-Hélène Antoine
Guest Editors
Manuscript Submission Information
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Keywords
- end-stage kidney disease
- hemodialysis/hemodiafiltration
- uremic toxins
- endothelial dysfunction
- gut microbiome
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