Uremic Toxins and Chronic Kidney Disease
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Uremic Toxins".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 1306
Special Issue Editors
2. Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
3. Department of Medicine, University of Cordoba, 14004 Cordoba, Spain
Interests: chronic kidney disease; CKD-MBD; prevention of renal progression
2. Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
3. Department of Medicine, University of Cordoba, 14004 Cordoba, Spain
Interests: chronic kidney disease; CKD-MBD; prevention of renal progression
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is increasingly recognized as a systemic disorder in which the accumulation of uremic toxins contributes to inflammation, oxidative stress, endothelial dysfunction, and cardiovascular morbidity. Particularly relevant are toxins largely derived from intestinal microbial metabolism of dietary precursors. Nutritional interventions that modulate toxin generation and clearance therefore represent a key therapeutic frontier. Emerging evidence shows that dietary protein restriction, increased intake of plant-based foods, and controlled supplementation with fiber or prebiotics can reduce circulating concentrations of several uremic solutes. Integrating such approaches within individualized nutritional care plans could help delay CKD progression and mitigate cardiovascular risk, reinforcing the great clinical relevance of the topic raised in this review. However, heterogeneity in dietary adherence, gut microbiota variability, and differences in residual renal function pose significant challenges. Future research should clarify optimal dietary patterns, define reliable biomarkers of uremic toxicity, and explore synergistic combinations of diet, pharmacologic, and dialysis-based strategies. Addressing the uremic milieu through nutrition is fundamental and implies a pathophysiological intervention. Tailored nutritional strategies targeting toxin production and gut–kidney interactions offer a tangible opportunity to improve survival and quality of life in CKD. The purpose of this Special Issue is to provide an updated overview of the complex interplay between nutrition, metabolic alterations, and the accumulation of uremic solutes across the spectrum of CKD. The Special Issue aims to gather original research, reviews, and clinical perspectives addressing how dietary patterns, nutritional therapies, and lifestyle interventions influence toxin generation, inflammation, oxidative stress, and cardiovascular and renal outcomes.
Dr. M. Victoria Pendón-RuizdeMier
Dr. Cristian Rodelo-Haad
Guest Editors
Manuscript Submission Information
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Keywords
- chronic kidney disease
- uremic toxins
- nutritional intervention
- prevention renal progression
- keto analogues
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