Special Issue "Molecular Basis of Air-Pollution-Induced Disease Risk"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Prof. Dr. Andrij Holian
Guest Editor
University of Montana Missoula, Department of Biomedical and Pharmaceutical Sciences, Missoula, USA
Interests: nanoparticles; particulate matter; asbestos; silica; alveolar macrophages; innate immunity; NLRP3 inflammasome; macrophage receptors; lysosomes
Special Issues and Collections in MDPI journals
Dr. Luke Montrose

Guest Editor
Department of Community and Environmental Health, Boise State University, 950 Lusk Street, Boise, ID 83725-1835, USA
Interests: DNA methylation; epigenetics; toxicoepigenetics; pyrosequencing; wood smoke; wildland firefighters; asthma; COPD; air pollution; environmental toxicology

Special Issue Information

Dear Colleagues,

Air pollution is a nondiscriminatory toxicant capable of traveling from exhausts, stacks, and forest fires to communities both near and far from the original source. Made up of both gases and liquids, air pollutants exist as mixtures of hundreds of substances, including ozone, nitrogen dioxide, carbon monoxide, particulate matter, polycyclic aromatic hydrocarbons, and many different volatile organic compounds. The toxicity of an air pollution particle—a mixture of solid and liquid droplets—is dependent on its size, source, and interaction with the environment. Acute impacts of air pollution such as increased respiratory symptoms and decreased lung function are well documented, but increasingly, air pollution exposure has been associated with chronic disease risk. While the causal drivers of air pollution’s influence on diseases such as cancer, cardiovascular disease, respiratory disease, and dementias remain to be fully elucidated, mechanistic evidence points to a number of key players, including inflammation, oxidative stress, and epigenetics.

This Special Issue invites papers focusing on plausible molecular mechanisms, whereby air pollutants influence disease risk and progression. In vivo and in vitro studies will be considered, as well as studies that investigate single-source and mixtures of air pollutants. For the purposes of this Special Issue, we define epigenetic modifications as DNA methylation, posttranslational histone tail modifications, chromatin accessibility, and noncoding RNA. Submissions may include original research articles or comprehensive reviews.

Prof. Dr. Andrij Holian
Dr. Luke Montrose
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • wildfire smoke
  • cooker stove
  • diesel exhaust particulate
  • TRAP
  • ozone
  • immune response
  • DNA methylation
  • biomass combustion
  • histone modification

Published Papers

This special issue is now open for submission.
Back to TopTop