Phthalates: Environmental Distribution, Human Exposure, and Health Risks

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1604

Editors


E-Mail Website
Guest Editor
Faculty of Health Sciences, University of Beira Interior (FCS-UBI), 6200-506 Covilhã, Portugal
Interests: cardiovascular diseases; vascular contractility; electrophysiology; cell signalling; endocrinology; endocrine disrupting chemicals; phthalates

E-Mail Website
Guest Editor
Faculty of Health Sciences, University of Beira Interior (FCS-UBI), 6200-506 Covilhã, Portugal
Interests: (cardio)vascular diseases; smooth muscle cells; endothelial cells; human health; fetoplacental vasculature; endocrine-disrupting chemicals; thyroid endocrine disruption; new approach methodologies
Special Issues, Collections and Topics in MDPI journals
Faculty of Health Sciences, University of Beira Interior (FCS-UBI), 6200-506 Covilhã, Portugal
Interests: cardiovascular diseases; vascular contractility; electrophysiology; cell signalling; endocrinology; endocrine disrupting chemicals; smooth muscle cells; endothelial cells; fetoplacental vasculature; new approach methodologies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phthalates are widely used plasticizers present in numerous consumer products, including food packaging, medical devices, and personal care items. Due to their non-covalent bind to plastics, these compounds are easily released into the environment, leading to widespread contamination of air, water, soil, and food. Consequently, human exposure to phthalates is ubiquitous and occurs through ingestion, inhalation, and dermal contact. Moreover, it is known that phthalates act as endocrine disruptors and may contribute to a variety of adverse health outcomes.

The scope of this Special Issue, titled, “Phthalates: Environmental Distribution, Human Exposure, and Health Risks”, lies within the presence of phthalates in the environment, routes of human exposure, and health effects, focusing on biomonitoring, toxicity mechanisms and risk assessment.

Thus, this Special Issue aims to provide an updated overview of the environmental distribution of phthalates, human exposure patterns, and the associated health effects. We welcome original research articles and reviews addressing environmental monitoring, exposure assessment, toxicological mechanisms, epidemiological studies, and emerging health risks related to phthalates. Interdisciplinary contributions that integrate environmental science, toxicology, public health, and biomedical research are particularly encouraged in order to improve our understanding of the impacts of phthalates and support the development of strategies to reduce human exposure and protect public health.

Dr. Melissa Rodrigues Mariana
Dr. Margarida Ferreira Lorigo
Dr. Elisa Cairrao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phthalates
  • environmental contamination
  • human exposure
  • endocrine disrupting chemicals
  • biomonitoring
  • toxicological mechanisms
  • health risk assessment

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

21 pages, 6926 KB  
Article
Neonatal Exposure to Di(2-ethylhexyl) Phthalate Is Associated with Lung Injury in a Rat Model of Chronic Lung Disease of Prematurity
by Shahana Perveen, Li Lou, Sohini Alim, Abigail Akselrod, Chunfang Zhao, Namita Sen, Clifford S. Deutschman and Annemarie Stroustrup
Toxics 2026, 14(6), 517; https://doi.org/10.3390/toxics14060517 - 12 Jun 2026
Viewed by 1143
Abstract
Chronic lung disease of prematurity (CLD) is a common complication of preterm birth with a complex pathology. Recent epidemiologic studies have identified a link between neonatal exposure to di(2-ethylhexyl) phthalate (DEHP), frequently used in medical equipment, and the development of CLD. We hypothesize [...] Read more.
Chronic lung disease of prematurity (CLD) is a common complication of preterm birth with a complex pathology. Recent epidemiologic studies have identified a link between neonatal exposure to di(2-ethylhexyl) phthalate (DEHP), frequently used in medical equipment, and the development of CLD. We hypothesize that DEHP exposure in the early neonatal period contributes to lung injury in newborn rats. Newborn rat pups were raised in one of the following environments: room air (RA), RA + DEHP, hyperoxia (60% oxygen), and hyperoxia + DEHP. Ambient DEHP was inhaled at a dose of 25 mg/m3 for 6 h daily for 14 days. Lung tissue and blood samples were collected on the 14th day of life. Independent exposure to DEHP and hyperoxia resulted in thicker pulmonary septal walls, fewer alveoli, increased pulmonary polymorphonuclear leukocytes and myeloperoxidase (MPO) activity and decreased expression of CD31 on endothelial cells in lung tissue. Additionally, DEHP-exposed rats showed higher serum malondialdehyde (MDA) levels and reduced vascular endothelial growth factor (VEGF) mRNA and protein levels compared to controls. Our experiments demonstrate that inhaled DEHP, with or without hyperoxia, resulted in a similar pattern of morphological lung injury and inflammation characteristic of CLD, suggesting an association with CLD of prematurity. Full article
Show Figures

Graphical abstract

Back to TopTop