Special Issue "Hazard Assessment of Endocrine Disrupting Chemicals in Invertebrates"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Ecotoxicology".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Prof. Dr. Miguel Machado Santos

Guest Editor
FCUP- Department of Biology, Faculty of Sciences & CIMAR/CIIMAR, LA — Interdisciplinary Centre of Marine and Environmental Research, Endocrine Disruptors and Emerging Contaminants Group, University of Porto, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal
Interests: endocrine disrupting chemicals; emerging pollutants, Nuclear Receptor signaling and evolution, mode of action (MOA), multi and transgenerational toxicity, embryo toxicity, reproductive toxicity, accidental marine spills
Dr. Luís Filipe C. Castro

Guest Editor
1 Faculty of Sciences (FCUP), Department of Biology, University of Porto (U.Porto), Porto, Portugal Contaminants Group, University of Porto, Porto, Portugal
2 Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal
Dr. Teresa Neuparth

Guest Editor
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal
Interests: endocrine disruptors; environmental risk assessment; invertebrate toxicity testing; transgenerational assays; long-term impact of contaminants; mechanistic studies

Special Issue Information

Dear colleagues,

Invertebrates represent the vast majority of all known animal species, inhabiting multiple habitats of the planet. Moreover, they perform key roles in various ecosystem functions. With the exception of the imposex phenomenon in gastropods, that is indisputably associated with organotin exposure and has received large attention in recent decades, most research in the field of endocrine-disrupting chemicals has focused on vertebrates. This is mostly related to the lack of knowledge of invertebrate endocrinology and available genomic resources. However, the full genome and transcriptome projects conducted for most invertebrate taxa over the past decade have brought about an unprecedent tool for addressing the hazard assessment of endocrine-disrupting chemicals in invertebrates. Several examples indisputably demonstrate that the genomic constitution of a given species is a key aspect that determines its response towards chemical insults. Therefore, disclosing the molecular constitution of different taxa is fundamental to understanding the mode of action (MoA) of environmental pollutants. Understanding the MoA of environmental chemicals allows the building of a toxicant response, thus becoming a central piece of hazard assessment.

For this Special Issue, we invite high-quality original research papers, short communications, and reviews focusing on all aspects of hazard assessment of endocrine-disrupting chemicals in invertebrates. Studies may be in vivo, in vitro, and in silico studies including both field and laboratory approaches. Research on single chemicals, mixtures, and complex environmental samples are welcome. We also welcome computational or predictive studies.

Prof. Dr. Miguel Machado Santos
Dr. Luís Filipe C. Castro
Dr. Teresa Neuparth
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • mode of action
  • invertebrate tax
  • endocrine-disrupting chemical
  • hazard assessment
  • toxicity testing

Published Papers

This special issue is now open for submission.
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