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Article

Oxidative Damage of Mussels Living in Seawater Enriched with Trace Metals, from the Viewpoint of Proteins Expression and Modification

1
Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece
2
Laboratory of Public Health, School of Medicine, University of Patras, 26504 Patras, Greece
*
Authors to whom correspondence should be addressed.
Dedicated to Late Professor Dimitrios L. Kalpaxis.
Toxics 2020, 8(4), 89; https://doi.org/10.3390/toxics8040089
Received: 25 September 2020 / Revised: 13 October 2020 / Accepted: 15 October 2020 / Published: 18 October 2020
(This article belongs to the Special Issue Hazard Assessment of Endocrine Disrupting Chemicals in Invertebrates)
The impact of metals bioaccumulation in marine organisms is a subject of intense investigation. This study was designed to determine the association between oxidative stress induced by seawater enriched with trace metals and protein synthesis using as a model the mussels Mytilus galloprovincialis. Mussels were exposed to 40 μg/L Cu, 30 μg/L Hg, or 100 μg/L Cd for 5 and 15 days, and the pollution effect was evaluated by measuring established oxidative biomarkers. The results showed damage on the protein synthesis machine integrity and specifically on translation factors and ribosomal proteins expression and modifications. The exposure of mussels to all metals caused oxidative damage that was milder in the cases of Cu and Hg and more pronounced for Cd. However, after prolonged exposure of mussels to Cd (15 days), the effects receded. These changes that perturb protein biosynthesis can serve as a great tool for elucidating the mechanisms of toxicity and could be integrated in biomonitoring programs. View Full-Text
Keywords: copper; mercury; cadmium; oxidative stress; protein carbonylation; translation factors; oxidative stress biomarkers copper; mercury; cadmium; oxidative stress; protein carbonylation; translation factors; oxidative stress biomarkers
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MDPI and ACS Style

Kournoutou, G.G.; Giannopoulou, P.C.; Sazakli, E.; Leotsinidis, M.; Kalpaxis, D.L.; Dinos, G.P. Oxidative Damage of Mussels Living in Seawater Enriched with Trace Metals, from the Viewpoint of Proteins Expression and Modification. Toxics 2020, 8, 89. https://doi.org/10.3390/toxics8040089

AMA Style

Kournoutou GG, Giannopoulou PC, Sazakli E, Leotsinidis M, Kalpaxis DL, Dinos GP. Oxidative Damage of Mussels Living in Seawater Enriched with Trace Metals, from the Viewpoint of Proteins Expression and Modification. Toxics. 2020; 8(4):89. https://doi.org/10.3390/toxics8040089

Chicago/Turabian Style

Kournoutou, Georgia G., Panagiota C. Giannopoulou, Eleni Sazakli, Michalis Leotsinidis, Dimitrios L. Kalpaxis, and George P. Dinos 2020. "Oxidative Damage of Mussels Living in Seawater Enriched with Trace Metals, from the Viewpoint of Proteins Expression and Modification" Toxics 8, no. 4: 89. https://doi.org/10.3390/toxics8040089

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