Human Biomonitoring in Health Risk Assessment of Emerging Chemicals

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1386

Special Issue Editors


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Guest Editor
School of Public Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, China
Interests: e-waste; disposable plastics; fast food; takeaway food; health risk; heavy metals; emerging contaminants; microbiota; metabolomics

E-Mail Website
Guest Editor
School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China
Interests: environmental contaminants; human exposure; organic pollutants; risk assessment; early life

Special Issue Information

Dear Colleagues,

The Special Issue "Human Biomonitoring in Health Risk Assessment of Emerging Chemicals" is a collection of research articles that explore the role of human biomonitoring in assessing the health risks associated with emerging chemicals. Human biomonitoring is a scientific approach that involves the measurement of chemicals or their metabolites in biological samples (such as blood, urine, hair, or tissues) collected from humans. This technique is used to assess exposure to various chemicals, including emerging contaminants, and to evaluate potential health risks associated with these exposures. This Special Issue would provide a valuable platform for researchers, policymakers, and stakeholders to share their latest findings and insights on the role of human biomonitoring in assessing health risks associated with emerging chemicals. By focusing on key areas such as emerging contaminants, biomarker development, population studies, health outcomes, and regulatory implications, this Special Issue could contribute to advancing our understanding of the potential health risks posed by these chemicals and inform efforts to protect public health.

Dr. Xiang Zeng
Dr. Shaoyou Lu
Guest Editors

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Keywords

  • biomonitoring
  • health risk
  • emerging chemicals
  • PFAS
  • PAEs
  • BPs
  • microplastics
  • 6PPD
  • dechlorane plus
  • heavy metals

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Published Papers (2 papers)

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Research

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19 pages, 19754 KiB  
Article
Protective Effects of Polygonatum sibiricum Polysaccharides Against Type 2 Diabetic Mice Induced by High-Fat Diet and Low-Dose Streptozotocin
by Qingxiangzi Li, Jufen Cheng, Yangyang Sun, Liang He and Rui Li
Toxics 2025, 13(4), 255; https://doi.org/10.3390/toxics13040255 - 28 Mar 2025
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Abstract
Polysaccharides possessing hypoglycemic effects have shown promising results in treating diabetes. Polygonatum sibiricum polysaccharide (PSP) is one of the most active ingredients in the Chinese medicine P. sibiricum Redoute with many biological activities. However, its efficacy in alleviating type 2 diabetes mellitus (T2DM) [...] Read more.
Polysaccharides possessing hypoglycemic effects have shown promising results in treating diabetes. Polygonatum sibiricum polysaccharide (PSP) is one of the most active ingredients in the Chinese medicine P. sibiricum Redoute with many biological activities. However, its efficacy in alleviating type 2 diabetes mellitus (T2DM) remains unexplored. Our aim is to evaluate the protective effect of PSP against T2DM by measuring body weight and serum biochemical indicators, examining the histopathological images of pancreatic and liver tissues, detecting fecal short-chain fatty acid (SCFA) content, and analyzing the intestinal flora diversity and the microbiota structure in T2DM mice. The findings indicated that PSP treatment in T2DM mice could obviously decrease the fasting blood glucose and fasting insulin levels, ameliorate glucose tolerance, insulin resistance, lipid, and inflammatory factor levels, attenuate pancreatic and liver damage, and increase the fecal SCFA content. In addition, PSP could modulate the composition of gut microbiota in T2DM mice, resulting in the relative abundance of Firmicutes decreasing and that of Bacteroidetes increasing, along with the abundance of beneficial flora significantly increasing, especially SCFA-producing bacteria. The findings indicate that PSP administration protected against diabetes by controlling disordered glucolipid metabolism and modulating the gut microbiota, which provides a valuable strategy for the utilization of PSP to treat T2DM. Full article
(This article belongs to the Special Issue Human Biomonitoring in Health Risk Assessment of Emerging Chemicals)
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Review

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33 pages, 602 KiB  
Review
Micro- and Nanoplastics and Fetal Health: Challenges in Assessment and Evidence from Epidemiological Studies
by Ankica Sekovanić, Tatjana Orct and Zorana Kljaković-Gašpić
Toxics 2025, 13(5), 388; https://doi.org/10.3390/toxics13050388 - 12 May 2025
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Abstract
The usage of plastics in life and industrial applications has led to global environmental pollution by micro- and nanoplastics (MPs/NPs). Despite their widespread occurrence in the environment, little is known about their presence in humans and the potential implications for human health, particularly [...] Read more.
The usage of plastics in life and industrial applications has led to global environmental pollution by micro- and nanoplastics (MPs/NPs). Despite their widespread occurrence in the environment, little is known about their presence in humans and the potential implications for human health, particularly maternal and fetal health during the prenatal and neonatal periods. Studies on experimental animals indicate that exposure to MPs/NPs can lead to neurological abnormalities in offspring and hemodynamic alterations in the placenta and fetal cerebral arteries. These findings underscore the need for further epidemiological studies that examine the effects of MPs/NPs on fetal health during pregnancy, a critical period for neurological development. This review summarizes the existing knowledge on the effects of prenatal exposure to MPs/NPs on fetal development and birth outcomes in humans and provides a detailed overview of the challenges encountered in contamination prevention, quality assurance and quality control in analytical procedures. It also discusses the sampling and digestion methods used for the extraction of MPs/NPs from biological samples of maternal and fetal origin, highlighting the difficulties associated with accurately quantifying these particles in complex biological matrices, identifying the gaps in current research, and suggesting recommendations to improve methodologies for assessing the risks associated with prenatal MP/NP exposure. Full article
(This article belongs to the Special Issue Human Biomonitoring in Health Risk Assessment of Emerging Chemicals)
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