Pesticide Risk Assessment, Emerging and Re-Emerging Problems

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Agrochemicals and Food Toxicology".

Deadline for manuscript submissions: 18 July 2025 | Viewed by 15548

Special Issue Editors


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Guest Editor
Department of Health Sciences, University of Milan, International Centre for Rural Health of the Santi Paolo e Carlo ASST of Milan, 20142 Milano, Italy
Interests: occupational health; human toxicology; public health; worker safety; occupational health surveillance
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Guest Editor
Analytical Toxicology and Metabonomics Laboratory, Department of Health Sciences, Faculty of Medicine of Università degli Studi di Milano at Ospedale San Paolo, 20142 Milan, Italy
Interests: analytical chemistry; mass spectrometry; toxicology; heavy metals; redox biomarkers; workplace contaminants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Half of the eight billion people in the world live and work in rural areas. They are mainly engaged in agriculture, which is considered by the WHO as one of the three most dangerous human activities, together with healthcare and the building sectors. Rural populations all over the world face several hazards in their daily lives and working activities. Among them, particular attention must be addressed at pesticides: these compounds must necessarily be toxic because they are used for controlling undesired living species, and, differing from other chemicals, must be spread in the environment in order to reach their targets. Since their toxicity is not specific for the target organisms, their use can endanger different living species, including humans. In this light, risk assessment of pesticide use is fundamental, but new challenges are appearing in this field: the pesticide market is quickly changing and new compounds are being introduced into the market, so a sound risk assessment for these compounds must be organized. Developed and industrialized countries have very structured systems for pesticide authorization, but similar systems are not affordable for developing and in-transition countries, which must rely on their own capacities or assessments performed out of their borders. Moreover, due to economic problems, obsolete pesticides are still marketed in these countries, bringing about specific risks. Due to several reasons, risk assessment in this field is quite complicated because it is expensive and technically difficult due to the great variability of the application scenarios, and, in any case, biological and environmental monitoring are performed after exposure occurs and not before. On the other hand, the big improvement of ITs makes new tools for risk assessment now available, mainly as models. Models represent potentially cost-effective and user-friendly tools that are adequate to perform risk assessment, but, at present, they are mainly addressed at the premarketing phase, with models that are usable during daily activities being absent but needed.

All these topics will be addressed in this Special Issue, which will accept research papers, commentaries, and reviews.

Prof. Dr. Claudio Colosio
Dr. Federico Maria Rubino
Guest Editors

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Keywords

  • agriculture
  • occupational risks
  • pesticides
  • risk assessment
  • models

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Published Papers (6 papers)

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Research

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24 pages, 4223 KiB  
Article
Chemical Prioritisation for Human Biomonitoring in Ireland: A Synergy of Global Frameworks and Local Perspectives
by Richa Singh, Holger Martin Koch, Marike Kolossa-Gehring and Alison Connolly
Toxics 2025, 13(4), 281; https://doi.org/10.3390/toxics13040281 - 7 Apr 2025
Viewed by 341
Abstract
Human biomonitoring (HBM) is a critical scientific tool for assessing human exposure by quantifying chemicals and their metabolites in biological specimens such as blood and urine. This approach provides a comprehensive and accurate evaluation of internal exposures from diverse sources and exposure routes. [...] Read more.
Human biomonitoring (HBM) is a critical scientific tool for assessing human exposure by quantifying chemicals and their metabolites in biological specimens such as blood and urine. This approach provides a comprehensive and accurate evaluation of internal exposures from diverse sources and exposure routes. In Ireland, establishing a national HBM programme requires a systematic chemical prioritisation process that aligns global frameworks with local public perceptions. This study integrates insights from international initiatives such as the European Joint Programme Human Biomonitoring for Europe (HBM4EU) and the Partnership for the Assessment of Risks from Chemicals (PARC)—along with HBM programmes from EU countries (Germany, France, Belgium, Norway, Slovenia, Czech Republic, and Sweden) and non-EU countries (US, Canada, South Korea, China, and New Zealand). In addition, a national survey was conducted to capture the perceptions of people in Ireland regarding chemicals of concern to develop a comprehensive priority list of chemicals and biomarkers. The broader chemical groups identified include heavy metals (lead, cadmium, mercury, arsenic, and chromium VI), plasticisers (phthalates), bisphenols, pesticides, flame retardants, PFASs (per- and polyfluoroalkyl substances), PAHs (polycyclic aromatic hydrocarbons), POPs (persistent organic compounds), VOCs (volatile organic compounds), and UV (ultraviolet) filters. This integrated, participatory approach provides a roadmap for a robust, adaptable chemical list that supports evidence-based policy decisions in HBM in Ireland and enhances public health outcomes. Full article
(This article belongs to the Special Issue Pesticide Risk Assessment, Emerging and Re-Emerging Problems)
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17 pages, 1681 KiB  
Article
Sicurpest: A Prototype of a User-Friendly Tool for Preventive Risk Assessment of Pesticide Use in Agriculture
by Federico Maria Rubino, Daniele Puri, Mario Fargnoli, Mara Lombardi, Stefan Mandić-Rajčević and Claudio Colosio
Toxics 2025, 13(2), 89; https://doi.org/10.3390/toxics13020089 - 24 Jan 2025
Cited by 1 | Viewed by 770
Abstract
In recent years, there has been a significant increase in attention towards the use of pesticides, as evidenced by the introduction of regulations aimed at ensuring their safe and environmentally responsible application. Although this stricter legislative framework offers potential benefits, the challenges faced [...] Read more.
In recent years, there has been a significant increase in attention towards the use of pesticides, as evidenced by the introduction of regulations aimed at ensuring their safe and environmentally responsible application. Although this stricter legislative framework offers potential benefits, the challenges faced by farmers, particularly those in small-scale operations, in complying with occupational health and safety (OHS) requirements are considerable. To address this issue, a research project was promoted by the Italian Workers’ Compensation Authority (INAIL) aimed at developing a user-friendly software tool to support farmers in planning pesticide applications in safe conditions. This study summarizes the results of the research, which consisted of three main phases: the definition of the main parameters that characterize the farmers’ exposure based on the analysis of the literature; the development of a risk assessment model that integrates these determinants with data provided by producers for each authorized pesticide; and the development of software tool (called SICURPEST) for a preliminary risk assessment when using pesticides. This tool serves as a preliminary risk assessment method, offering a simplified model for practical use by farmers. Its initial verification was conducted through a case study and the results represent a step towards promoting safer pesticide practices, providing a solid basis for further validation. Full article
(This article belongs to the Special Issue Pesticide Risk Assessment, Emerging and Re-Emerging Problems)
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14 pages, 1799 KiB  
Article
Alzheimer’s Disease Mortality Rate: Correlation with Socio-Economic and Environmental Factors
by Valfran da Silva Lima, Yasmin Gabriele Ferreira, Júlio Cezar de Oliveira, Vanessa de Almeida Raia, Ludmila Barbosa Bandeira Rodrigues Emerick, Lucinéia Reuse Albiero, Valéria Dornelles Gindri Sinhorin and Guilherme Luz Emerick
Toxics 2024, 12(8), 586; https://doi.org/10.3390/toxics12080586 - 13 Aug 2024
Viewed by 2276
Abstract
The progressive increase in the number of deaths caused by Alzheimer’s disease (AD) in Brazil and around the world between 2010 and 2020 raises questions in scientific society. At the same time, there is also an increase in life expectancy at birth (LEB). [...] Read more.
The progressive increase in the number of deaths caused by Alzheimer’s disease (AD) in Brazil and around the world between 2010 and 2020 raises questions in scientific society. At the same time, there is also an increase in life expectancy at birth (LEB). Thus, the aim of this study was, for the first time, to compare the increase in AD mortality rate (ADMR) in Brazilian regions over the years 2010 to 2020 with the increase in LEB, and investigate the possible correlation between these demographic transition phenomena and pesticide sales and exposure during this period. Data were extracted from the Brazilian Institute of Geography and Statistics (IBGE), from the Department of Informatics and Technology of the Brazilian Ministry of Health (DATASUS) and from the Brazilian Institute of the Environment and Renewable Natural Resources (IBAMA). There was a significant increase in life expectancy at birth and in ADMR over the years between 2010 and 2020 in all Brazilian regions, with the female population in the South region being the most affected. In conclusion, there is a strong positive correlation between the increase in ADMR and LEB; ADMR and Human Development Index (HDI) and ADMR and pesticide sales and exposure in Brazil over the years studied. Full article
(This article belongs to the Special Issue Pesticide Risk Assessment, Emerging and Re-Emerging Problems)
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28 pages, 3112 KiB  
Article
In Vitro Human Dermal Absorption Studies on Pesticides in Complex Mixtures: Investigation of Guidance Criteria and Possible Impact Parameters
by Christina Pieper, Nadine Engel, Korinna Wend, Carsten Kneuer and Sabine Martin
Toxics 2024, 12(4), 248; https://doi.org/10.3390/toxics12040248 - 28 Mar 2024
Viewed by 1817
Abstract
Pesticides must not pose unacceptable risks to human health, so risk assessments are conducted before products are authorised. Dermal exposure is often the main route of intake, so estimating realistic and trustworthy dermal absorption values is crucial for risk assessment. Although there are [...] Read more.
Pesticides must not pose unacceptable risks to human health, so risk assessments are conducted before products are authorised. Dermal exposure is often the main route of intake, so estimating realistic and trustworthy dermal absorption values is crucial for risk assessment. Although there are agreed test guidelines for in vitro dermal absorption studies, not every product is tested due to cost reasons. The present dataset consists of 945 individual in vitro experiments on the dermal absorption of human skin with 179 active substances of pesticides in 353 different mixtures, including concentrates and dilutions. The dataset was evaluated to identify the possible impacts of experimental conditions and physico-chemical properties on dermal absorption. The dataset was also analysed to assess the appropriateness of the pro rata correction for untested dilutions, and the set concentration cut-off to decide on the dilution status for choosing a default value on dermal absorption. The study found that the implementation of specific guidelines improved the harmonisation of study conduct, with support for approaches such as pro rata correction and default values. Further analysis of the specific co-formulants may identify influencing factors that may be more important than the experimental variables. Full article
(This article belongs to the Special Issue Pesticide Risk Assessment, Emerging and Re-Emerging Problems)
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Review

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26 pages, 3645 KiB  
Review
Pesticides vs. Biopesticides: From Pest Management to Toxicity and Impacts on the Environment and Human Health
by Gabriel Mihăiță Daraban, Raluca-Maria Hlihor and Daniela Suteu
Toxics 2023, 11(12), 983; https://doi.org/10.3390/toxics11120983 - 4 Dec 2023
Cited by 35 | Viewed by 8851
Abstract
The environmental pollution that occurs in direct response to the widespread use of man-made/conventional pesticides results from many chemicals that require a long period of time, often decades, to degrade. The synthetic nature of pesticides also harms animals, beneficial insects, microorganisms, and plants, [...] Read more.
The environmental pollution that occurs in direct response to the widespread use of man-made/conventional pesticides results from many chemicals that require a long period of time, often decades, to degrade. The synthetic nature of pesticides also harms animals, beneficial insects, microorganisms, and plants, as well as humans. Fortunately, however, there are many natural pesticides, the so-called biopesticides, that are also effective against pests and more importantly, do not interfere with the well-being of ecosystems. Consequently, most biopesticides are safer for use around people and pets than man-made pesticides because, for example, they can be easily washed away from fruits and vegetables. The natural habitat is a rich resource with a wide selection of plants, many of which are also used to treat diseases in humans, animals, and plants. Out of concern for public health, environmental safety, and the stringent regulation of pesticide residues in agricultural commodities, the use of biopesticides is becoming increasingly important, but questions regarding potential pest resistance to these products may arise, just as is the case with conventional pesticides. Therefore, the performance and potential role of biopesticides in the management of plant pests should be prioritized due to their sustainability and importance to human and environmental welfare. In this review, we propose to highlight a scenario in which we discuss in detail the main constraints posed by the use of pesticides compared to biopesticides, starting with issues regarding their definition and continuing on to issues related to their toxicity and their impact on the environment and human health. Full article
(This article belongs to the Special Issue Pesticide Risk Assessment, Emerging and Re-Emerging Problems)
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Other

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16 pages, 603 KiB  
Systematic Review
New Methodologies and Techniques for Biomonitoring Pesticide Exposure in Agricultural Workers: A Systematic Review
by Andreia Moreira, Joana Guedes and Manuela Vieira da Silva
Toxics 2025, 13(2), 104; https://doi.org/10.3390/toxics13020104 - 28 Jan 2025
Viewed by 710
Abstract
Biomonitoring allows for the assessment of internal exposure to various pesticides and metabolites. Following PRISMA guidelines, this systematic review aims to summarise innovative biomonitoring techniques for assessing pesticide exposure in agricultural workers, their advantages and limitations, and their applicability. The search of the [...] Read more.
Biomonitoring allows for the assessment of internal exposure to various pesticides and metabolites. Following PRISMA guidelines, this systematic review aims to summarise innovative biomonitoring techniques for assessing pesticide exposure in agricultural workers, their advantages and limitations, and their applicability. The search of the Medline/PubMed, ScienceDirect, Scopus, and Web of Science databases identified 14 articles dealing with new techniques for biomonitoring pesticide exposure in agricultural workers. These new methodologies have identified several biomarkers associated with exposure to organophosphates. Most of the included studies combine and/or improve traditional methods to overcome their limitations. This leads to more sensitive, specific, and precise techniques with lower detection and quantification limits. Therefore, it is necessary to thoroughly analyse and test new biomonitoring methods for assessing pesticide exposure. These techniques can complement qualitative risk assessments and aid in developing strategies to protect public health and the environment. Full article
(This article belongs to the Special Issue Pesticide Risk Assessment, Emerging and Re-Emerging Problems)
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