Symmetry/Asymmetry in Micro/Nanofluidic Devices and Applications

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Engineering and Materials".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 577

Special Issue Editors


E-Mail Website
Guest Editor
School of Mechanical and Electric Engineering, Soochow University, Suzhou 215299, China
Interests: lab on a chip; microfluidcs and nanofluidics; droplet microfluidics; organ on a chip

E-Mail Website
Guest Editor
College of Mechanical and Electrical Engineering, Northeast Forestry University, Harbin 150040, China
Interests: microfluidcs and nanofluidics; droplet microfluidics; heat transfer
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Mechanical and Electric Engineering, Soochow University, Suzhou 215299, China
Interests: microfluidcs and nanofluidics; droplet microfluidics; organ on a chip; microrobotics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidics and nanofluidics are transformative fields that deal with the behavior and manipulation of fluids at the microscale and nanoscale, respectively. The design of micro- and nanofluidic devices is critical due to their widespread use in various applications, including, but are not limited to, biochemical reactions, biosensing, single-cell analysis, next-generation sequencing, microparticle synthesis, drug delivery, energy harvesting, and sample deposition. The effective design and function of these devices often hinge on the strategic use of symmetry and asymmetry, allowing for the development of highly efficient systems capable of performing complex operations at a very small scale. By intentionally breaking or exploiting the symmetric or asymmetric flow within microfluidic systems, researchers can manipulate samples with precision, enabling a wide array of specific applications and enhancing the performance of these cutting-edge devices.

This Special Issue of the journal Symmetry focuses on the innovative use of symmetry and asymmetry in the realm of micro/nanofluidic devices. It is dedicated to showcasing recent advancements in the field, where symmetry and asymmetry are not just fundamental concepts but are actively harnessed to model, design, and fabricate new devices. The issue aims to explore how these principles influence the performance and functionality of micro/nanofluidic systems and how they can be applied in practical scenarios to solve real-world problems. It encompasses a wide array of topics, from theoretical studies to experimental investigations, and from device fabrication to applications in diverse fields such as medicine, chemistry, biology, and engineering.

Dr. Haizhen Sun
Dr. Kailiang Zhang
Prof. Dr. Hao Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lab on a chip
  • micromixer
  • microreactor
  • micro/nano sensor
  • micro/nano fabrication
  • droplet manipulation
  • heat transfer
  • drug delivery
  • single-cell analysis
  • micro/nano robotics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 2907 KiB  
Article
Flexible Concentration Gradient Droplet Generation via Partitioning–Recombination in a Shear Flow-Driven Multilayer Microfluidic Chip
by Linkai Yu, Qingyang Feng, Yifan Chen, Yongji Wu, Haizhen Sun, Hao Yang and Lining Sun
Symmetry 2025, 17(6), 826; https://doi.org/10.3390/sym17060826 - 26 May 2025
Cited by 1 | Viewed by 277
Abstract
Concentration gradient generation plays a pivotal role in advancing applications across drug screening, chemical synthesis, and biomolecular studies, yet conventional methods remain constrained by labor-intensive workflows, limited throughput, and inflexible gradient control. This study presents a novel multilayer microfluidic chip leveraging shear flow-driven [...] Read more.
Concentration gradient generation plays a pivotal role in advancing applications across drug screening, chemical synthesis, and biomolecular studies, yet conventional methods remain constrained by labor-intensive workflows, limited throughput, and inflexible gradient control. This study presents a novel multilayer microfluidic chip leveraging shear flow-driven partitioning–recombination mechanisms to enable the flexible and high-throughput generation of concentration gradient droplets. The chip integrates interactive upper and lower polydimethylsiloxane (PDMS) layers, where sequential fluid distribution and recombination are achieved through circular and radial channels while shear forces from the oil phase induce droplet formation. Numerical simulations validated the dynamic pressure-driven concentration gradient formation, demonstrating linear gradient profiles across multiple outlets under varied flow conditions. The experimental results revealed that the shear flow mode significantly enhances mixing uniformity and droplet generation efficiency compared to continuous flow operations, attributed to intensified interfacial interactions within contraction–expansion serpentine channels. By modulating hydrodynamic parameters such as aqueous- and oil-phase flow rates, this system achieved tunable gradient slopes and droplet sizes, underscoring the intrinsic relationship between flow dynamics and gradient formation. The proposed device eliminates reliance on complex channel networks, offering a compact and scalable platform for parallelized gradient generation. This work provides a robust framework for optimizing microfluidic-based concentration gradient systems, with broad implications for high-throughput screening, combinatorial chemistry, and precision biomolecular assays. Full article
(This article belongs to the Special Issue Symmetry/Asymmetry in Micro/Nanofluidic Devices and Applications)
Show Figures

Figure 1

Back to TopTop