Symmetry and Asymmetry in Chromato-Mass-Spectrometry Analysis

Dear Colleagues,

Chromatography, mass spectrometry, and their symbiosis—gas chromatography–mass spectrometry—are some of the most common analytical methods at the present.

According to the results of major international exhibitions, instruments that implement these methods account for up to 70% of all analytical instruments. An important place is occupied by the analysis of chiral (optically active) objects.

The most important consumer of chiral separations is pharmaceutical chemistry. The biological activity of different isomers often differs dramatically, which requires special synthesis, preparative separation, and, most importantly, analytical control over the content of each specific isomer.

This issue will be devoted to the use of chromatography, mass spectrometry, and gas chromatography-mass spectrometry in the analysis of chiral (optically active) objects. Such work began in the sixties of the last century with the work of E. Gil-Av with coworkers (1966). They succeeded in separating optical isomers for volatile amino acid derivatives using gas chromatography on a stationary liquid phase synthesized from chiral leucine. The next stage was the creation of chiral chromatography in the variant of ligand exchange chromatography proposed by V.A. Davankov (1968). The method made it possible to obtain pure substances with high resolution from unmodified racemic mixtures. Further improvement of methods for the separation of optical isomers made it possible to create various techniques for chromatographic and mass spectrometric analysis. The development of gas chromatography–mass spectrometry technology has made it possible to combine both methods and thereby increase the reliability of separation and identification of optical isomers.

We invite specialists working in the field of chemical synthesis, preparative isolation, and isomer-specific analysis to submit publications for a Special Issue on gas chromatography–mass spectrometric methods for the analysis of optical isomers.

Submit your paper and select the Journal “Symmetry” and the Special Issue “Symmetry and Asymmetry in Chromato-Mass-Spectrometry Analysis” via: MDPI submission system. Our papers will be published on a rolling basis and we will be pleased to receive your submission once you have finished it.

Prof. Dr. Aleksey Konstantinovich Buryak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• chromatography
• mass spectrometry (MS)
• gas chromatography-mass spectrometry (GC-MS)
• optically active objects
• separation of optically isomers
• chiral objects