Biological Relationship Between Skeletal Muscle and Whole-Body Health
A special issue of Sports (ISSN 2075-4663).
Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 12417
Special Issue Editor
Special Issue Information
Dear Colleagues,
Skeletal muscle accounts for ~40% of total body mass and ~75% of variability in the basal metabolic rate, which is, on average, the largest component of total daily energy expenditure, and is the only tissue in the human body capable of increasing metabolic demand >1,000-fold in response to extreme metabolic stress. Whole-body health tracks with skeletal muscle function, and skeletal muscle health is reliant on the maintenance of mitochondrial function. Diminished skeletal muscle and mitochondrial function is now evident in the etiology and/or pathology of many diseases and disorders, especially metabolic disease. Moreover, biological decrements concomitant to aging are complementary to diminished skeletal muscle and mitochondrial function. The direction that these relationships take is largely attributed to the regularity and magnitude of energetic flux through skeletal muscle. Exercise is a necessary strategy to stimulate and/or maintain skeletal muscle and mitochondrial function across the lifespan. Accordingly, it is paramount to identify the physiology of skeletal muscle and mitochondrial function vs. dysfunction, and discuss how energetic flux relates to both. Therefore, the aim of this Special Issue is to discuss the biological relationship between skeletal muscle as well as mitochondrial function in relation to whole-body health.
Dr. Robert A. Jacobs
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondria
- aging
- insulin resistance
- redox
- contraction
- exercise
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