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Surface-Enhanced Raman Scattering Biosensors: Technologies and Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Sensing and Imaging".

Deadline for manuscript submissions: 15 February 2026 | Viewed by 623

Special Issue Editor

Special Issue Information

Dear Colleagues,

Surface-Enhanced Raman Scattering (SERS) Biosensors have numerous applications. This detection technology is advancing rapidly in chemistry, environmental science, food safety, materials science, medical diagnosis, biochemistry, and life sciences. On the one hand, it is motivated by the requirements of numerous and increasingly demanding biological and biomedical sensing applications; on the other hand, it is intimately tied to the availability of sensitive and repeatable ready-to-use SERS substrates.

This Special Issue offers a unique chance to combine the results of these two research areas: SERS-based biosensor fabrication and application. Its primary goal is to review cutting-edge fabrication technologies (ranging from nanomaterials with tunable shapes and nanostructures to surface bio-functionalization) as well as cutting-edge applications, such as the detection of ex vivo biofluids and biomolecules, DNAs, and microRNAs; disease diagnosis; monitoring of cellular properties such as pH, temperature, and ion concentrations; and single-cell detection and identification.

Dr. Stefano Fornasaro
Guest Editor

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Keywords

  • SERS
  • nanostructures
  • substrates

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Published Papers (1 paper)

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Research

14 pages, 1360 KiB  
Article
Increasing the Sensitivity of Aspergillus Galactomannan ELISA Using Silver Nanoparticle-Based Surface-Enhanced Raman Spectroscopy
by A. D. Vasilyeva, L. V. Yurina, E. G. Evtushenko, E. S. Gavrilina, V. B. Krylov, N. E. Nifantiev and I. N. Kurochkin
Sensors 2025, 25(14), 4376; https://doi.org/10.3390/s25144376 - 13 Jul 2025
Viewed by 318
Abstract
Galactomannan (GM) is a polysaccharide secreted by opportunistic pathogenic fungi of the Aspergillus genus. It is prescribed as a diagnostic biomarker of invasive aspergillosis in immunocompromised patients by the guidelines for diagnosis and management of Aspergillus diseases. It has been shown previously that [...] Read more.
Galactomannan (GM) is a polysaccharide secreted by opportunistic pathogenic fungi of the Aspergillus genus. It is prescribed as a diagnostic biomarker of invasive aspergillosis in immunocompromised patients by the guidelines for diagnosis and management of Aspergillus diseases. It has been shown previously that the measurement of soluble horseradish peroxidase (HRP) using surface-enhanced Raman scattering (SERS) of 2,3-diaminophenazine enzymatic reaction product on silver nanoparticles is largely superior in detection limit compared to colorimetric readout. In this study, a highly sensitive SERS-based HRP measurement protocol was applied to enzyme-linked immunosorbent assay (ELISA) for GM quantification in biological fluids. The detection limit for GM was 4.3 pg per sample, which is one and a half orders of magnitude lower compared to colorimetric detection with o-phenylenediamine as a substrate and five times more sensitive than ELISA using 3,3′,5,5′-tetramethylbenzidine. Full article
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