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Practical Applications of Surface Enhanced Raman Spectroscopy (SERS)

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Surface Sciences and Technology".

Deadline for manuscript submissions: closed (20 March 2023) | Viewed by 3143

Special Issue Editors


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Guest Editor
Raman Spectroscopy Lab, Department of Engineering and Architecture, University of Trieste, 34100 Trieste, Italy
Interests: materials; Raman spectroscopy; nanotechnologies

Special Issue Information

Dear Colleagues,

Surface-enhanced Raman scattering (SERS) spectroscopy has been proven to be a powerful sensing technique for probing molecules in contact or proximity to a plasmonic substrate, usually a metal surface, but, more recently, also to semiconductors or hybrid materials. Since its discovery over 40 years ago, it has enjoyed a steady growth of interest in general as well as in target-oriented applications, such as biosensing, the monitoring of bacterial contamination, environmental analysis, liquid biopsy, therapeutic drug monitoring, renewable energy and catalysis. SERS applications are now also benefitting from the use of advanced analytical methods provided by chemometrics and machine learning.

In this Special Issue, we invite researchers from interdisciplinary fields to submit original articles and reviews exploring practical applications of SERS spectroscopy to resolve technological and analytical needs in several fields, including, but not limited to:

  • Novel SERS substrates for practical applications;
  • SERS applications in energy devices;
  • SERS applications in biological and biomedical sensors;
  • Microfluidic SERS;
  • Chemometrics and machine learning in SERS analysis.

Dr. Stefano Fornasaro
Prof. Dr. Valter Sergo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sensors
  • chemometrics
  • biomedical
  • catalysis
  • electrochemistry
  • substrates
  • pollutants

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Published Papers (1 paper)

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Research

16 pages, 10114 KiB  
Article
Ultrafast Detection of SARS-CoV-2 Spike Protein (S) and Receptor-Binding Domain (RBD) in Saliva Using Surface-Enhanced Raman Spectroscopy
by Mohammed Ba Abdullah, Chahinez Dab, Mohammed Almalki, Abdullah Alnaim, Alaaedeen Abuzir and Chawki Awada
Appl. Sci. 2022, 12(10), 5039; https://doi.org/10.3390/app12105039 - 17 May 2022
Cited by 12 | Viewed by 2613
Abstract
Controlling contagious diseases necessitates using diagnostic techniques that can detect infection in the early stages. Although different diagnostic tools exist, there are still challenges related to accuracy, rapidity, cost-effectiveness, and ease of use. Surface-enhanced Raman spectroscopy (SERS) is a rapid, simple, less expensive, [...] Read more.
Controlling contagious diseases necessitates using diagnostic techniques that can detect infection in the early stages. Although different diagnostic tools exist, there are still challenges related to accuracy, rapidity, cost-effectiveness, and ease of use. Surface-enhanced Raman spectroscopy (SERS) is a rapid, simple, less expensive, and accurate method. We continue our previous work published on SERS detection of the SARS-CoV-2 receptor-binding domain (RBD) in water. In this work, we replace water with saliva to detect SARS-CoV-2 proteins at very low concentrations and during a very short time. We prepared a very low concentration of 10−9 M SARS-CoV-2 spike protein (S) and SARS-CoV-2 receptor-binding domain (RBD) in saliva to mimic a real case scenario. Then, we drop them on a SERS substrate. Using modified SERS measurements on the control and the sample containing the biomolecules, confirmed the sensitivity of the target identification. This technique provides different diagnostic solutions that are fast, simple, non-destructive and ultrasensitive. Simulation of the real-world of silicon wire covered with silver and gold, were performed using an effective and accurate tool, COMSOL Multiphysics software, for the enhancement properties study. Full article
(This article belongs to the Special Issue Practical Applications of Surface Enhanced Raman Spectroscopy (SERS))
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