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Special Issue "Electrochemical Nanosensors for Analysis of Pharmaceuticals"

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Sensor Materials".

Deadline for manuscript submissions: 1 September 2021.

Special Issue Editor

Prof. Dr. Biljana Nigovic
E-Mail Website
Guest Editor
University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovacica 1, 10000 Zagreb, Croatia
Interests: pharmaceutical analysis; electroanalytical methods; nanosensors; modified electrodes; capillary electrophoresis; chromatography; bioactive compounds

Special Issue Information

Dear Colleagues,

The development of novel electrochemical nanosensors and associated sensing approaches is one of the most captivating topics in modern pharmaceutical analysis. Different nanomaterials offer almost unlimited possibilities for new sensor platform designs to address the growing needs for enhanced sensitivity, selectivity, rapid response, reliable measuring in untreated samples, on-site testing, and miniaturization of sensing elements. Electrochemical nanosensors cover a large domain of investigation in pharmaceutical analysis ranging from the determination of active pharmaceutical ingredients in pharmaceutical dosage forms ensuring safety, efficacy, and high quality of medicines, as well as in biological samples to obtain effective therapy and prevent overdose-induced toxicity. The monitoring of therapeutic drug concentration is a critical subject in clinical and pharmacokinetic studies and important component of personalized medicine. Furthermore, electrochemical nanosensors can be used at the early stage of drug research to screen the activity of newly synthesized molecules due to correlations noted between redox potential and pharmacological activity. Electron transfer reactions play an important role in understanding the mechanism of action of various drugs and can serve as a useful tool in the design of more active and safer pharmaceuticals. The knowlage of redox properties of drugs can give insights into their metabolic fate or in vivo redox processes. Nanomaterial-based sensors have applications in drug–protein binding and drug–DNA interaction studies, giving results which are useful in drug bioavailability and toxicity tests.

Electrochemical nanosensors are a rapidly growing research area in pharmaceutical sciences. Nanomaterials such as nanotubes, nanofibers, nanowires, nanoparticles, quantum dots, fullerene, graphene, and nanodiamonds have recently found a wide range of interesting pharmaceutical and biomedical applications. They are very attractive in the field of sensor development due to their unique characteristics and advantageous properties for electroanalysis, such as enhanced electronic properties, high electrical conductivity, excellent chemical stability, and high surface-to-volume ratio. To improve the selectivity of nanomaterials to target drug molecules as well as their adsorption capacity related to enhanced sensitivity, various functionalization strategies can be applied for the fabrication of novel sensors. Electrochemical nanosensors have lower detection limits for pharmaceuticals, excellent electrocatalytic properties, good reproducibility, and limited access of interferences in a complex samples when compared with other sensors.

The aim of this Special Issue is to publish original research articles and reviews that cover recent advances in the application of electrochemical nanosensors for investigation and analysis of pharmaceuticals and pharmacologically active molecules.

Prof. Dr. Biljana Nigovic
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon nanotubes
  • graphene
  • nanoparticles
  • nanocomposites
  • electrochemical sensor design
  • electroanalysis
  • pharmaceutical analysis
  • biomedical applications
  • biological samples

Published Papers (1 paper)

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Research

Open AccessArticle
Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid
Sensors 2021, 21(4), 1161; https://doi.org/10.3390/s21041161 - 07 Feb 2021
Viewed by 481
Abstract
A novel hybrid composite of conductive poly(methylene blue) (PMB) and carbon nanotubes (CNT) was prepared for the detection of 5-aminosalicylic acid (5-ASA). Electrosynthesis of PMB with glassy carbon electrode (GCE) or with carbon nanotube modified GCE was done in ethaline deep eutectic solvent [...] Read more.
A novel hybrid composite of conductive poly(methylene blue) (PMB) and carbon nanotubes (CNT) was prepared for the detection of 5-aminosalicylic acid (5-ASA). Electrosynthesis of PMB with glassy carbon electrode (GCE) or with carbon nanotube modified GCE was done in ethaline deep eutectic solvent of choline chloride mixed with ethylene glycol and a 10% v/v aqueous solution. Different sensor architectures were evaluated in a broad range of pH values in a Britton-Robinson (BR) buffer using electrochemical techniques, chronoamperometry (CA), and differential pulse voltammetry (DPV), to determine the optimum sensor configuration for 5-ASA sensing. Under optimal conditions, the best analytical performance was obtained with CNT/PMBDES/GCE in 0.04 M BR buffer pH 7.0 in the range 5–100 µM 5-ASA using the DPV method, with an excellent sensitivity of 9.84 μA cm−2 μM−1 (4.9 % RSD, n = 5) and a detection limit (LOD) (3σ/slope) of 7.7 nM, outclassing most similar sensors found in the literature. The sensitivity of the same sensor obtained in CA (1.33 μA cm−2 μM−1) under optimal conditions (pH 7.0, Eapp = +0.40 V) was lower than that obtained by DPV. Simultaneous detection of 5-ASA and its analogue, acetaminophen (APAP), was successfully realized, showing a catalytic effect towards the electro-oxidation of both analytes, lowering their oxidation overpotential, and enhancing the oxidation peak currents and peak-to-peak separation as compared with the unmodified electrode. The proposed method is simple, sensitive, easy to apply, and economical for routine analysis. Full article
(This article belongs to the Special Issue Electrochemical Nanosensors for Analysis of Pharmaceuticals)
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