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Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid

1
Department of Chemistry, CEMMPRE, Faculty of Sciences and Technology, University of Coimbra, 3004-535 Coimbra, Portugal
2
Department of Analytical Chemistry, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
3
National Institute of Material Physics, 077125 Magurele, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Biljana Nigovic
Sensors 2021, 21(4), 1161; https://doi.org/10.3390/s21041161
Received: 12 January 2021 / Revised: 4 February 2021 / Accepted: 4 February 2021 / Published: 7 February 2021
(This article belongs to the Special Issue Electrochemical Nanosensors for Analysis of Pharmaceuticals)
A novel hybrid composite of conductive poly(methylene blue) (PMB) and carbon nanotubes (CNT) was prepared for the detection of 5-aminosalicylic acid (5-ASA). Electrosynthesis of PMB with glassy carbon electrode (GCE) or with carbon nanotube modified GCE was done in ethaline deep eutectic solvent of choline chloride mixed with ethylene glycol and a 10% v/v aqueous solution. Different sensor architectures were evaluated in a broad range of pH values in a Britton-Robinson (BR) buffer using electrochemical techniques, chronoamperometry (CA), and differential pulse voltammetry (DPV), to determine the optimum sensor configuration for 5-ASA sensing. Under optimal conditions, the best analytical performance was obtained with CNT/PMBDES/GCE in 0.04 M BR buffer pH 7.0 in the range 5–100 µM 5-ASA using the DPV method, with an excellent sensitivity of 9.84 μA cm−2 μM−1 (4.9 % RSD, n = 5) and a detection limit (LOD) (3σ/slope) of 7.7 nM, outclassing most similar sensors found in the literature. The sensitivity of the same sensor obtained in CA (1.33 μA cm−2 μM−1) under optimal conditions (pH 7.0, Eapp = +0.40 V) was lower than that obtained by DPV. Simultaneous detection of 5-ASA and its analogue, acetaminophen (APAP), was successfully realized, showing a catalytic effect towards the electro-oxidation of both analytes, lowering their oxidation overpotential, and enhancing the oxidation peak currents and peak-to-peak separation as compared with the unmodified electrode. The proposed method is simple, sensitive, easy to apply, and economical for routine analysis. View Full-Text
Keywords: ethaline deep eutectic solvent; 5-aminosalicylic acid; poly(methylene blue); nanostructured polymer film; electrochemical sensor ethaline deep eutectic solvent; 5-aminosalicylic acid; poly(methylene blue); nanostructured polymer film; electrochemical sensor
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MDPI and ACS Style

Hosu, O.; Barsan, M.M.; Săndulescu, R.; Cristea, C.; Brett, C.M.A. Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid. Sensors 2021, 21, 1161. https://doi.org/10.3390/s21041161

AMA Style

Hosu O, Barsan MM, Săndulescu R, Cristea C, Brett CMA. Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid. Sensors. 2021; 21(4):1161. https://doi.org/10.3390/s21041161

Chicago/Turabian Style

Hosu, Oana, Madalina M. Barsan, Robert Săndulescu, Cecilia Cristea, and Christopher M.A. Brett 2021. "Hybrid Nanocomposite Platform, Based on Carbon Nanotubes and Poly(Methylene Blue) Redox Polymer Synthesized in Ethaline Deep Eutectic Solvent for Electrochemical Determination of 5-Aminosalicylic Acid" Sensors 21, no. 4: 1161. https://doi.org/10.3390/s21041161

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