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Optical Nanosensors for Environmental and Biomedical Monitoring

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Optical Sensors".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 330

Special Issue Editors


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Guest Editor
CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
Interests: nanosensors; plasmonic materials; surface-enhanced Raman scattering-based detection; rapid detection; microfluidics; paper-based chips
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Materials Science and Engineering, University of Jinan, Jinan 250022, China
Interests: functional precious metal nanomaterials; plasmonic sensors; nanomedicine

Special Issue Information

Dear Colleagues,

Optical nanosensors are a class of nanoscale sensing systems that utilize optical principles for detection, offering advantages such as high sensitivity, rapid response, and multifunctionality. In recent years, optical nanosensors have demonstrated significant potential in environmental and biomedical monitoring, including applications in pollutant detection, pathogen identification, and disease biomarker screening. Due to their unique capabilities, optical nanosensors have become powerful tools for addressing complex detection challenges and have achieved remarkable progress in fields such as environmental monitoring, clinical diagnostics, and health management.

For this Special Issue, we cordially invite you to submit original research papers and review articles to foster a discussion on the current status, challenges, and prospects of optical nanosensors in environmental and biomedical monitoring. We hope that this Special Issue will promote interdisciplinary collaboration, drive innovation in optical nanosensing technologies, and contribute to solving monitoring challenges in environmental and health-related fields. This Special Issue will cover all aspects of optical nanosensors, including the latest developments in the following areas: novel optical nanosensor design, optical sensing mechanisms, synthesis and functionalization of nanomaterials, multimodal sensing strategies, environmental pollutant detection, biomarker identification, real-time monitoring systems, and other related technologies. If you are unsure whether your work falls within the scope of this Special Issue, please contact its editor before submission.

Dr. Zhiyang Zhang
Dr. Ling Chen
Guest Editors

Manuscript Submission Information

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Keywords

  • optical nanosensors
  • colorimetric sensor
  • lateral flow test
  • quantum dot sensor
  • SERS sensor
  • environmental monitoring
  • real-time monitoring
  • pollutant detection
  • biomedical detection
  • point-of-care testing
  • disease diagnostics
  • biomarker
  • pathogen detection

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Published Papers (1 paper)

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Research

13 pages, 4270 KiB  
Article
Fabricating a Three-Dimensional Surface-Enhanced Raman Scattering Substrate Using Hydrogel-Loaded Freeze-Induced Silver Nanoparticle Aggregates for the Highly Sensitive Detection of Organic Pollutants in Seawater
by Hai Liu, Yufeng Hu and Zhiyang Zhang
Sensors 2025, 25(8), 2575; https://doi.org/10.3390/s25082575 - 18 Apr 2025
Viewed by 248
Abstract
Surface-enhanced Raman scattering (SERS) spectroscopy faces challenges in achieving both high sensitivity and reproducibility for the detection of real samples, particularly in high-salinity matrices. In this study, we developed a high-performance, salt-resistant three-dimensional (3D) SERS substrate by integrating physically induced colloidal silver nanoparticle [...] Read more.
Surface-enhanced Raman scattering (SERS) spectroscopy faces challenges in achieving both high sensitivity and reproducibility for the detection of real samples, particularly in high-salinity matrices. In this study, we developed a high-performance, salt-resistant three-dimensional (3D) SERS substrate by integrating physically induced colloidal silver nanoparticle aggregates (AgNAs) with an agarose hydrogel. AgNAs were prepared using a freeze–thaw–ultrasonication method to minimize interference in SERS signals while significantly enhancing the detection efficiency of trace pollutants. The incorporation of the agarose hydrogel not only improved the substrate’s pollutant enrichment capability, but also effectively prevented the aggregation and sedimentation of AgNAs in salt solutions. The developed SERS substrate exhibited an ultralow detection limit of 10−12 M for Nile Blue (NB), with a 100-fold increase in sensitivity compared to colloidal AgNAs and drop-cast AgNAs solid substrates. The analytical enhancement factor (AEF) for malachite green (MG) achieved a value of 1.4 × 107. Furthermore, the substrate demonstrated excellent signal uniformity, with a relative standard deviation (RSD) of 6.74% within a 200 μm × 200 μm detection area and also show a satisfactory RSD of only 9.38% within a larger area of 1 mm × 1 mm. Notably, the 3D SERS substrate exhibited excellent stability under high-salinity conditions (0.5 M NaCl) and successfully detected a model pollutant (MG) in real seawater samples using the standard addition method. This study provides a novel strategy for highly sensitive SERS detection of trace pollutants in saline environments, offering promising applications in environmental monitoring and marine pollution analysis. Full article
(This article belongs to the Special Issue Optical Nanosensors for Environmental and Biomedical Monitoring)
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