Advances in Surface Plasmon Resonance Biosensors
A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".
Deadline for manuscript submissions: 10 September 2025 | Viewed by 153
Special Issue Editors
Interests: electrochemistry; analytical chemistry; screen-printed electrodes (SPEs); electrochemical biosensors; amperometric; proteins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Surface Plasmon Resonance (SPR) affinity biosensors are powerful tools for real-time monitoring of molecular interactions. They operate by detecting changes in the refractive index (RI) caused by the binding of a ligand in solutions of a bioreceptor (e.g., antibodies, oligonucleotides) immobilized on a thin metal surface, typically gold (up to 50 nm thick). The underlying SPR effect arises from the interaction of light with the metal surface, and most conventional SPR devices use the Kretschmann configuration, which leverages total internal reflection to excite surface plasmons.
Some of the unique advantages of SPR biosensors include the following: (i) versatile surface biofunctionalization by a wide range of surface chemistries that enable efficient immobilization of diverse biorecognition elements; (ii) robustness when operating in complex environments, such as human biofluids (plasma, serum, and whole blood) or food matrices; (iii) automated detection for high-throughput analysis; and (iv) enabling multiplex analysis for simultaneous monitoring of multiple analytes in the same sample.
The unique capabilities of SPR biosensors have driven innovations in several fields, including food safety and quality control, environmental analysis and monitoring of contaminants, and drug discovery and disease diagnostics, with biomarker detection being used for prompt medical intervention. Furthermore, recent advancements have integrated SPR technology into portable bioanalytical systems, such as plasmonic optical fiber or lab-on-a-chip devices, broadening its accessibility for on-site applications or point-of-care diagnostics.
This Special Issue addresses the combination of precision, flexibility, and portability of SPR technology for biosensing applications.
Dr. José Ribeiro
Dr. João P. Mendes
Guest Editors
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Keywords
- Surface Plasmon Resonance (SPR)
- plasmonic biosensors
- optical detection
- portable diagnostic devices
- miniaturization techniques
- food analysis
- environmental analysis
- disease biomarkers
- biomedical applications
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