Special Issue "Proteomics in Cancer Research"
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 15196
Interests: protein–protein interactions and their relation to disease; cell proliferation and differentiation; serum biomarkers for diagnosis and prognosis of cancer and psychiatric problems; analytical biochemistry; protein chemistry; mass spectrometry
In recent years, proteomics has become one of the most important tools that can be used in understanding the behavior of proteins, protein post-translational modifications and protein–protein interactions.
The human genome has been sequenced and it suggests that, with about 30,000 genes, we are not very complicated. Yet, a multi-exon eukaryotic gene can direct the formation of multiple protein isoforms, with multiple subcellular locations, membrane and non-membrane bound, within multiple tissues and organs. One of the best-known examples is tropomyosin, which is different in different organs and tissues (i.e., brain vs. muscle) and can be both membrane-bound or not, depending on the structure of the exon 9 of its gene. Another good example is represented by immunoglobulins G, or antibodies, which can have different isotypes, which are both soluble and membrane-bound isoproteins.
In addition to the formation of multiple isoproteins with multiple functions, our uniqueness also relies on post-translational modifications of these proteins. Some of them are transiently modified, in response to a stimulus (i.e., phosphorylation during activation of receptor tyrosine kinase pathways), while others are sentenced to death by tagging (i.e., ubiquitin tagging). Lastly, the important roles of interactions between our proteins through stable (i.e., protein complexes) and transient (i.e., upon a response to a stimulus) protein–protein interactions force us to understand that proteins, in a protein-centric world, makes us complex, and capable to adapt and evolve to the constantly changing environment. Therefore, the ~30,000 genes which direct the millions and millions of proteins, isoproteins, post-translationally modified proteins, and stable and transient protein–protein interactions make us complicated and capable to adapt and evolve. Changes at the protein level also allow us to identify indicators of cancer, either through early detection or predictions of cancer progression, or even prediction of the body’s response to treatment.
This Special Issue of Proteomes welcomes submissions of original research or review articles aiming at deciphering physiological processes with the use of proteomics tools. Contributions will deal with the dynamics of proteins in their native and modified forms, with the combination of several “omics” approaches in contrasted physiological situations as well as with technical advances in the proteomic field.
Prof. Dr. Costel C. Darie
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Proteomes is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Protein post-translational modifications
- Quantitative proteomics
- Cancer detection