Biomedical Applications of Genome-Scale Metabolic Network Models
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".
Deadline for manuscript submissions: closed (20 June 2021) | Viewed by 4787
Special Issue Editor
Special Issue Information
Dear Colleagues,
Genome-scale metabolic networks are computational models that can describe the associations between genes, proteins (generally enzymes or transcription factors), and metabolic reactions. These models can be used to predict modifications in metabolic networks and, therefore, describe variations in the metabolic fluxes in response to changes in the system surrounding conditions, such as those that happen due to gene mutations, drug action or diet changes. The applications of these models in the biomedical field are enormous and will likely provide a wide basis for the development of better disease diagnose and treatment procedures. The determination of the unknown molecular mechanisms of complex diseases and the prediction of the molecular evolution of drug treatments are some of the many possible applications of genome-scale metabolic network models in biomedicine.
This Special Issue on “Biomedical Applications of Genome-Scale Metabolic Network Models” aims to gather outstanding research and literature reviews that cover this huge field. Topics include but are not limited to the following:
- Network models that enable drug repurposing
- Metabolic networks to determine the molecular mechanisms of disease
- Identification of novel drug targets through network analysis
- New bioinformatic approaches to study genome-scale metabolic networks
- Evaluation of the genotype-phenotype relationship in different diseases through computer modeling
- Tools for prediction of the outcome of certain treatments using network modeling
- Metabolic network reconstruction for a new organism with biomedical applications
Prof. Dr. Carlos Leon
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- network modeling
- biomedicine
- genomics
- proteomics
- metabolomics
- metabolic reconstruction
- network medicine
