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Journals
Processes
Special Issues
Development of Functional Probiotics and Advances in Biotechnology
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Development of Functional Probiotics and Advances in Biotechnology

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 431

Special Issue Editors

Dr. Yilan Liu

E-Mail Website
Guest Editor
Department of Chemical Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada
Interests: synthetic biology for sustainable development; Functional probiotics for affordable and preventive health solutions; biomanufacturing; genetic tools exploring; bio-nanoparticles bio-upc; improvements in PCR technology; bio-nanoparticles; bio-upcycling of mixed waste for sustainable development; dynamic regulation of bioprocess
Dr. Hongmei Liu

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
Interests: biomedical; tumor therapy; biomaterials; nanoparticles
Dr. Jinjin Chen

E-Mail Website
Guest Editor
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada
Interests: functional food; probiotics; genetics; metabolic engineering; biotechnology; biochemical engineering

Special Issue Information

Dear Colleagues,

Probiotics are live microorganisms that can improve gut health by promoting the growth of beneficial bacteria in the gut microbiome, which is crucial for maintaining a healthy immune system and overall wellbeing. The research field of functional probiotics has rapidly evolved in recent years with the increasing demand for functional foods and personalized nutrition for specific health benefits and the potential for large-scale production. Biotechnology has played a critical role in advancing probiotic research, enabling the development of new strains with improved functionality and efficacy.

We are excited to invite researchers and experts in the field of biotechnology to submit their latest research to this Special Issue “Development of Functional Probiotics and Advances in Biotechnology”. Topics include, but are not limited to:

  1. Isolation, characterization, and analysis of any potential probiotic
  2. Innovative techniques for improving the function/efficacy of probiotics.
  3. Therapeutic implications of genetically engineered probiotics.
  4. The effects of functional probiotics on the immune system and overall well-being.
  5. The use of bioreactors for the large-scale production of probiotics.
  6. Processing and storage of functional probiotics.

Dr. Yilan Liu
Dr. Hongmei Liu
Dr. Jinjin Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional probiotics, gut microbiome
  • biotechnology
  • gene editing
  • immune system
  • bioreactors

Published Papers (1 paper)

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Research

15 pages, 4181 KiB  
Article
In Vitro Screening of Lactic Acid Bacteria with RAW264.7 Macrophages and the Immunoregulatory Mechanism
by Yuemei Lu, Yanyang Wu, Lina Pan, Jiaqi Wang, Rongxue Tang, Fangming Deng, Wenli Kang and Lingyan Zhao
Processes 2024, 12(5), 903; https://doi.org/10.3390/pr12050903 (registering DOI) - 29 Apr 2024
Viewed by 112
Abstract
Lactic acid bacteria (LAB) are commonly consumed as probiotics to improve gut barrier function and boost the immune system. This study aimed to screen LAB with high immunomodulatory activity using RAW264.7 macrophages. According to the results, Limosilactobacillus reuteri AUc2301 was selected from 84 [...] Read more.
Lactic acid bacteria (LAB) are commonly consumed as probiotics to improve gut barrier function and boost the immune system. This study aimed to screen LAB with high immunomodulatory activity using RAW264.7 macrophages. According to the results, Limosilactobacillus reuteri AUc2301 was selected from 84 screened strains that can stimulate RAW264.7 cell proliferation. Limosilactobacillus reuteri AUc2301 significantly enhanced the phagocytosis activity of RAW264.7 cells. In the ELISA test, Limosilactobacillus reuteri AUc2301 significantly promoted the release of interleukin-6, IL-1β, the tumor necrosis factor, and nitric oxide in RAW264.7 macrophages. In addition, Limosilactobacillus reuteri AUc2301 significantly inhibited the excessive release of IL-6, IL-1β, TNF-α, prostaglandin E2 as well as NO and the high expression of cyclooxygenase-2 in RAW264.7 macrophages induced by lipopolysaccharide. In further mechanism studies, Limosilactobacillus reuteri AUc2301 could regulate the nuclear factor-κB signaling pathway in RAW264.7 macrophages. Collectively, the screened Limosilactobacillus reuteri AUc2301 showed good immunomodulatory activity in vitro, and it has the potential to be developed as a novel probiotic. Full article
(This article belongs to the Special Issue Development of Functional Probiotics and Advances in Biotechnology)
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