Special Issue "Polymeric Carriers for Biomedical and Nanomedicine Application"

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 20 April 2020.

Special Issue Editors

Dr. Sofia Lima
E-Mail Website
Guest Editor
LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Portugal, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
Interests: cell culture; colloids; magnetic nanoparticles; marine polysaccharides; liposomes; lipid nanoparticles; photothermal therapy; polymeric nanoparticles
Prof. Salette Reis
E-Mail Website
Guest Editor
Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal
Interests: medicinal chemistry; infectious, inflamatory and cancer diseases; nanotechnology and nanodelivery; development of “smart” drug systems; biophysics and drug-membrane interactions
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to contribute a full article, short communication, or review article to the Special Issue entitled “Polymeric Carriers for Biomedical and Nanomedicine Applications”, which is anticipated to include topics on synthetic and natural polymers as materials for drug delivery, such as nanoparticles and hydrogels, to elicit specific biological responses. Polymers contribute to the development of carriers to improve drug delivery in a targeted and sustainable manner, but also to the optimization of disease diagnostic tools. Several advances have been described in the application of polymers in the biomedical field given their special mechanical, physical, chemical, and biological characteristics. Unravelling the mechanism of action of these polymeric biomaterials in a biological context is also important to enhance their successful translation to clinical trials.

This Special Issue will focus on the development of polymeric delivery systems towards biomedical and nanomedicine applications as well as on understanding how such biomaterials interact under biological conditions. Contributions related to the advances in materials (e.g., functionalization, responsiveness), design and characterization, cellular interactions, and assessment using in vitro, ex vivo, and in vivo disease modes, and biomedical applications will provide knowledge on the polymer–biology interface. The topics are not limited to these studies and can cover all research areas concerning polymeric materials applied in the nanomedicine field.

We would very much appreciate if you would consider being one of our authors. We look forward to your contribution.

Dr. Sofia Lima
Prof. Salette Reis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biological barriers interaction
  • Biomedical devices
  • Controlled release
  • Drug delivery systems
  • Functional nanoparticles
  • Stimuli-responsiveness
  • Targeted systems

Published Papers (1 paper)

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Research

Open AccessArticle
p47phox siRNA-Loaded PLGA Nanoparticles Suppress ROS/Oxidative Stress-Induced Chondrocyte Damage in Osteoarthritis
Polymers 2020, 12(2), 443; https://doi.org/10.3390/polym12020443 (registering DOI) - 13 Feb 2020
Abstract
Osteoarthritis (OA) is the most common joint disorder that has had an increasing prevalence due to the aging of the population. Recent studies have concluded that OA progression is related to oxidative stress and reactive oxygen species (ROS). ROS are produced at low [...] Read more.
Osteoarthritis (OA) is the most common joint disorder that has had an increasing prevalence due to the aging of the population. Recent studies have concluded that OA progression is related to oxidative stress and reactive oxygen species (ROS). ROS are produced at low levels in articular chondrocytes, mainly by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and ROS production and oxidative stress have been found to be elevated in patients with OA. The cartilage of OA-affected rat exhibits a significant induction of p47phox, a cytosolic subunit of the NADPH oxidase, similarly to human osteoarthritis cartilage. Therefore, this study tested whether siRNA p47phox that is introduced with poly (D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (p47phox si_NPs) can alleviate chondrocyte cell death by reducing ROS production. Here, we confirm that p47phox si_NPs significantly attenuated oxidative stress and decreased cartilage damage in mono-iodoacetate (MIA)-induced OA. In conclusion, these data suggest that p47phox si_NPs may be of therapeutic value in the treatment of osteoarthritis. Full article
(This article belongs to the Special Issue Polymeric Carriers for Biomedical and Nanomedicine Application)
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