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Pharmaceutics
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Innovative Nano-Delivery Systems: Bridging One Health Approaches for Human, Animal,...
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Innovative Nano-Delivery Systems: Bridging One Health Approaches for Human, Animal, and Environmental Well-Being

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1358

Special Issue Editor

Dr. Sofia Lima

E-Mail Website
Guest Editor
LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
Interests: cell culture; colloids; magnetic nanoparticles; marine polysaccharides; liposomes; lipid nanoparticles; photothermal therapy; polymeric nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue "Innovative Nano-Delivery Systems: Bridging One Health Approaches for Human, Animal, and Environmental Well-Being" aims to explore the transformative role of nano-delivery technologies in addressing interconnected health challenges across humans, animals, and the environment. As the One Health framework emphasizes the interdependence of these domains, there is an urgent need for innovative tools to tackle shared threats such as antimicrobial resistance, zoonotic diseases, and environmental contamination.

This Special Issue invites contributions that highlight the design, development, and application of nano-delivery systems, such as nanoparticles, liposomes, and nanocarriers, to improve drug delivery, diagnostics, and therapeutic efficacy. Topics include, but are not limited to, targeted treatments for infectious diseases, vaccine delivery systems, environmental remediation of contaminants, and precision therapeutics in veterinary medicine. By bringing together multidisciplinary research, this issue seeks to advance nano-technological solutions that foster sustainable health practices and improve global health outcomes in a rapidly changing world.

Dr. Sofia Lima
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticle
  • nanocarrier
  • antimicrobial

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Published Papers (1 paper)

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Research

18 pages, 3294 KiB  
Article
Curcumin-Loaded Lipid Nanoparticles: A Promising Antimicrobial Strategy Against Enterococcus faecalis in Endodontic Infections
by Sónia Ferreira, Liliana Grenho, Maria Helena Fernandes and Sofia A. Costa Lima
Pharmaceutics 2025, 17(1), 108; https://doi.org/10.3390/pharmaceutics17010108 - 14 Jan 2025
Viewed by 1173
Abstract
Background/Objectives: This study aims to evaluate the efficacy of curcumin (CUR), a natural polyphenol with potent antimicrobial and anti-inflammatory properties, when formulated as solid lipid nanoparticles (CUR-loaded SLN) against Enterococcus faecalis. Methods: Solid lipid nanoparticles (SLNs) were prepared as a carrier for [...] Read more.
Background/Objectives: This study aims to evaluate the efficacy of curcumin (CUR), a natural polyphenol with potent antimicrobial and anti-inflammatory properties, when formulated as solid lipid nanoparticles (CUR-loaded SLN) against Enterococcus faecalis. Methods: Solid lipid nanoparticles (SLNs) were prepared as a carrier for CUR, which significantly improved its solubility. SLNs made with cetyl palmitate and Tween 80 were obtained via the hot ultrasonication method. The physicochemical properties of CUR-loaded SLNs were evaluated, including their size, stability, and release profile. Antimicrobial testing was conducted against both sessile and planktonic E. faecalis populations. Cytotoxicity was assessed on human gingival fibroblasts. Results: The CUR-loaded SLNs exhibited about 200 nm and a −25 mV surface potential, and the encapsulation of CUR did not affect the physicochemical properties of SLNs. CURs were released from SLNs in a controlled and sustained manner over 100 h. The nanoparticles remained stable for at least two months when stored at 4 °C or 25 °C, making them suitable for clinical use. Antioxidant activity was confirmed through DPPH and ABTS assays. Free CUR significantly reduced the planktonic E. faecalis CFU counts by approximately 65% after 24 h of exposure. However, this inhibitory effect diminished with longer exposure times (48 and 72 h). Antimicrobial activity studies of CUR-loaded SLNs showed dose- and time-dependent effects, in the 2.5–10 µg/mL range, against both sessile and planktonic E. faecalis populations, over 24 to 72 h. The CUR-loaded SLNs showed good cytocompatibility with human fibroblasts up to 2.5 μg/mL, suggesting low toxicity. Conclusions: CUR-loaded SLNs demonstrate significant antimicrobial activity against E. faecalis, along with good cytocompatibility, indicating their potential as an effective adjunct therapy in endodontic treatments. Full article
(This article belongs to the Special Issue Innovative Nano-Delivery Systems: Bridging One Health Approaches for Human, Animal, and Environmental Well-Being)
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