Special Issue "Biological Barrier-Specific Drug Delivery Designs"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Dr. Cláudia Nunes
Guest Editor
LAQV, REQUIMTE, Pharmacy Faculty of Porto University
Interests: drug–membrane interactions; cellular membrane biophysics; drug delivery systems for targeted delivery
Prof. Salette Reis
Guest Editor
Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, Portugal
Interests: medicinal chemistry; infectious, inflamatory and cancer diseases; nanotechnology and nanodelivery; development of “smart” drug systems; biophysics and drug-membrane interactions
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Collegues,

At present, there is an increasing research effort for the development of more efficient therapies able to target and deliver bioactive compounds or drug molecules to specific sites. The strategies behind it aim at the reduction of off-target effects and an enhanced efficacy while reducing the concentration of active molecules. There are many hurdles in this path, and probably the major challenge lays on crossing the biological barriers that are indispensable for the integrity and function of many human organs. Further, most of the time, bioactive compound pharmacodynamics and pharmacokinetics are affected by their interaction with physiological barriers. Indeed, bioactive compounds, drugs, and nanoparticles need to cross biological barriers to reach their target and, in some cases, act at the barrier level.

In this context, this issue aims to gather new strategies and approaches to target, cross or act in different body barriers such as skin, lung, gastrointestinal, and blood brain barriers, mouth and nasal mucosas, and cellular membranes. Furthermore, and once biological barriers are not exclusively from the body, drug delivery systems aiming at biofilms are also included. In this field, the development of in vitro, ex vivo, and in vivo models and visualization tools for the assessment of delivery system interaction with the barriers are also key.

Dr. Cláudia Nunes
Prof. Salette Reis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • drug transport across barriers
  • uptake mechanisms
  • nanosystems
  • targeted delivery
  • pharmaceutical quality by design

Published Papers

This special issue is now open for submission.
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