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Polymers
Special Issues
Biodegradable Materials for Tissue Engineering
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Biodegradable Materials for Tissue Engineering

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 9812

Special Issue Editors

Prof. Dr. Jiashing Yu

E-Mail Website
Guest Editor
Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
Interests: costumed-design of Biomaterials; surface modification of biomaterials to enhance cell and extracellular matrix interaction; antibody and peptides conjugated nanoparticles as biosensors and drug delivery vehicles for cancer therapy; Stem Cell and Tissue engineering; cell encapsulation and 3D culture; biological microbubbles for cardiac and stem cells
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ren-Jei Chung

E-Mail Website
Guest Editor
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan
Interests: biomaterials; electrochemical biosensors; nanobiotechnology; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biodegradable polymers can be classified as synthetic or natural polymers. In industry, synthetic materials are mostly obtained from petroleum resources while natural polymers are derived from biological resources or renewable resources. Biodegradable polymers can degrade either by hydrolysis (without the enzyme catalysis) or by enzymatic mechanisms. Hydrolysis is the main degradation mechanism of the biodegradable polymers, but depending on the polymer structure, they can also undergo at least partial enzymatic degradation.
Research works focused on developing bioactive materials that combine the engineering properties of synthetic polymers with the biological properties of natural materials. Advanced biodegradable polymers that can trigger predictable and beneficial cellular/tissue responses, both in the cell culture platform and in the host environment.
This Special Issue covers the fundamental aspects of biodegradable polymers such as synthesis, characterization, and mechanistic discussion, as well as application aspects such as synergistic effects, surface modification, and functional examination.

Prof. Jia-Shing Yu
Prof. Ren-Jei Chung
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biodegradable
  • bioabsorbable
  • biomaterials
  • scaffold
  • tissue engineering
  • regenerative medicine
  • hydrogel

Published Papers (3 papers)

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Research

16 pages, 9629 KiB  
Article
3D Printing of Collagen/Oligomeric Proanthocyanidin/Oxidized Hyaluronic Acid Composite Scaffolds for Articular Cartilage Repair
by Chung-Fei Lee, Yung-Heng Hsu, Yu-Chien Lin, Thu-Trang Nguyen, Hsiang-Wen Chen, Sasza Chyntara Nabilla, Shao-Yi Hou, Feng-Cheng Chang and Ren-Jei Chung
Polymers 2021, 13(18), 3123; https://doi.org/10.3390/polym13183123 - 16 Sep 2021
Cited by 16 | Viewed by 2908
Abstract
Articular cartilage defects affect millions of people worldwide, including children, adolescents, and adults. Progressive wear and tear of articular cartilage can lead to progressive tissue loss, further exposing the bony ends and leaving them unprotected, which may ultimately cause osteoarthritis (degenerative joint disease). [...] Read more.
Articular cartilage defects affect millions of people worldwide, including children, adolescents, and adults. Progressive wear and tear of articular cartilage can lead to progressive tissue loss, further exposing the bony ends and leaving them unprotected, which may ultimately cause osteoarthritis (degenerative joint disease). Unlike other self-repairing tissues, cartilage has a low regenerative capacity; once injured, the cartilage is much more difficult to heal. Consequently, developing methods to repair this defect remains a challenge in clinical practice. In recent years, tissue engineering applications have employed the use of three-dimensional (3D) porous scaffolds for growing cells to regenerate damaged cartilage. However, these scaffolds are mainly chemically synthesized polymers or are crosslinked using organic solvents. Utilizing 3D printing technologies to prepare biodegradable natural composite scaffolds could replace chemically synthesized polymers with more natural polymers or low-toxicity crosslinkers. In this study, collagen/oligomeric proanthocyanidin/oxidized hyaluronic acid composite scaffolds showing high biocompatibility and excellent mechanical properties were prepared. The compressive strengths of the scaffolds were between 0.25–0.55 MPa. Cell viability of the 3D scaffolds reached up to 90%, which indicates that they are favorable surfaces for the deposition of apatite. An in vivo test was performed using the Sprague Dawley (SD) rat skull model. Histological images revealed signs of angiogenesis and new bone formation. Therefore, 3D collagen-based scaffolds can be used as potential candidates for articular cartilage repair. Full article
(This article belongs to the Special Issue Biodegradable Materials for Tissue Engineering)
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13 pages, 2964 KiB  
Article
Enzyme-Crosslinked Gelatin Hydrogel with Adipose-Derived Stem Cell Spheroid Facilitating Wound Repair in the Murine Burn Model
by Ting-Yu Lu, Kai-Fu Yu, Shuo-Hsiu Kuo, Nai-Chen Cheng, Er-Yuan Chuang and Jia-Shing Yu
Polymers 2020, 12(12), 2997; https://doi.org/10.3390/polym12122997 - 16 Dec 2020
Cited by 32 | Viewed by 5629
Abstract
Engineered skin that can facilitate tissue repair has been a great advance in the field of wound healing. A well-designed dressing material together with active biological cues such as cells or growth factors can overcome the limitation of using auto-grafts from patients. Recently, [...] Read more.
Engineered skin that can facilitate tissue repair has been a great advance in the field of wound healing. A well-designed dressing material together with active biological cues such as cells or growth factors can overcome the limitation of using auto-grafts from patients. Recently, many studies showed that human adipose-derived stem cells (hASCs) can be used to promote wound healing and skin tissue engineering. hASCs have already been widely applied for clinical trials. hASCs can be harvested abundantly because they can be easily isolated from fat tissue known as the stromal vascular fraction (SVF). On the other hand, increasing studies have proven that cells from spheroids can better simulate the biological microenvironment and can enhance the expression of stemness markers. However, a three-dimensional (3D) scaffold that can harbor implanted cells and can serve as a skin-repaired substitute still suffers from deficiency. In this study, we applied a gelatin/microbial transglutaminase (mTG) hydrogel to encapsulate hASC spheroids to evaluate the performance of 3D cells on skin wound healing. The results showed that the hydrogel is not toxic to the wound and that cell spheroids have significantly improved wound healing compared to cell suspension encapsulated in the hydrogel. Additionally, a hydrogel with cell spheroids was much more effective than other groups in angiogenesis since the cell spheroid has the possibility of cell–cell signaling to promote vascular generation. Full article
(This article belongs to the Special Issue Biodegradable Materials for Tissue Engineering)
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13 pages, 3428 KiB  
Article
Elucidation of Antimicrobial Silver Sulfadiazine (SSD) Blend/Poly(3-Hydroxybutyrate-co-4-Hydroxybutyrate) Immobilised with Collagen Peptide as Potential Biomaterial
by Sevakumaran Vigneswari, Tana Poorani Gurusamy, H. P. S. Abdul Khalil, Seeram Ramakrishna and Al-Ashraf Abdullah Amirul
Polymers 2020, 12(12), 2979; https://doi.org/10.3390/polym12122979 - 14 Dec 2020
Cited by 8 | Viewed by 2234
Abstract
The quest for a suitable biomaterial for medical application and tissue regeneration has resulted in the extensive research of surface functionalization of material. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] is a bacterial polymer well-known for its high levels of biocompatibility, non-genotoxicity, and minimal [...] Read more.
The quest for a suitable biomaterial for medical application and tissue regeneration has resulted in the extensive research of surface functionalization of material. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] is a bacterial polymer well-known for its high levels of biocompatibility, non-genotoxicity, and minimal tissue response. We have designed a porous antimicrobial silver SSD blend/poly(3HB-co-4HB)-collagen peptide scaffold using a combination of simple techniques to develop a scaffold with an inter-connected microporous pore in this study. The collagen peptide was immobilised via -NH2 group via aminolysis. In order to improve the antimicrobial performance of the scaffold, silver sulfadiazine (SSD) was impregnated in the scaffolds. To confirm the immobilised collagen peptide and SSD, the scaffold was characterized using FTIR. Herein, based on the cell proliferation assay of the L929 fibroblast cells, enhanced bioactivity of the scaffold with improved wettability facilitated increased cell proliferation. The antimicrobial activity of the SSD blend/P(3HB-co-4HB)-collagen peptide in reference to the pathogenic Gram-negative, Gram-positive bacteria and yeast Candida albicans exhibited SSD blend/poly(3HB-co-4HB)-12.5 wt% collagen peptide as significant construct of biocompatible antibacterial biomaterials. Thus, SSD blend/P(3HB-co-4HB)-collagen peptide scaffold from this finding has high potential to be further developed as biomaterial. Full article
(This article belongs to the Special Issue Biodegradable Materials for Tissue Engineering)
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