Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.6
5.0
Journals
Polymers
Special Issues
Advanced Polymer-Based Composites for Biomedical Applications
share announcement

Advanced Polymer-Based Composites for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Composites and Nanocomposites".

Deadline for manuscript submissions: closed (5 September 2023) | Viewed by 7932

Special Issue Editors

Dr. Bahareh Azimi

E-Mail Website
Guest Editor
Department of Civil and Industrial Engineering, University of Pisa, 56122 Pisa, Italy
Interests: electrospinning; electrospray; solution spinning; biomaterials; biopolymers; piezoelectric materials; tissue engineering; drug delivery, wound dreesing
Special Issues, Collections and Topics in MDPI journals
Dr. Serena Danti

E-Mail Website
Guest Editor
1. Department of Civil and Industrial Engineering, University of Pisa, Largo L. Lazzarino 2, 56122 Pisa, Italy
2. Department of Civil and Environmental Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA
Interests: electrospinning; biomaterials; biomedical polymers; piezoelectric materials; smart materials; tissue engineering; advanced in vitro models
Special Issues, Collections and Topics in MDPI journals
Dr. Fatemeh Mokhtari

E-Mail Website
Guest Editor
SMART Infrastructure Facility, Engineering and Information Sciences, University of Wollongong, Wollongong 2522, Australia
Interests: energy harvesting; piezoelectric; sensors; smart textiles; wearable technology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Increasing demand for medical products based on biomaterials due to population expansion and aging has led to vast growth in biomedical research in recent years. Advances in materials preparation and characterization techniques are an important issue for the development of better-performing devices in the field of biomaterials engineering. Polymer-based composites represent a highly interesting class of biomaterials that nowadays have drawn attention in various biomedical applications as their physical and mechanical properties can be tuned to accomplish specific needs. For example, they could be ideal for tissue engineering scaffolds and drug delivery systems.

This Special Issue on “Advanced Polymer Composites for Biomedical Applications” will cover research from different fields, including biomaterials engineering, tissue engineering, drug delivery, and modeling. This Special Issue is devoted to research related to the production of multifunctional polymer-based composite materials, their physicochemical and biological characterization, and their biomedical applications. Full articles, short communications, and review articles on this topic are welcome.

Dr. Bahareh Azimi
Dr. Serena Danti
Dr. Fatemeh Mokhtari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer-based composites
  • biodegradable polymers
  • biomedical applications
  • tissue engineering
  • drug delivery
  • regenerative medicine
  • biosensor

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 4577 KiB  
Article
Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles
by Xuelian Chen, Lijia Liu, Chen Shen, Fangyan Liu, Enyu Xu, Yin Chen and Wang Jie
Polymers 2023, 15(11), 2510; https://doi.org/10.3390/polym15112510 - 30 May 2023
Cited by 1 | Viewed by 1587
Abstract
In recent years, natural polysaccharides have been widely used in the preparation of drug delivery systems. In this paper, novel polysaccharide-based nanoparticles were prepared by layer-by-layer assembly technology using silica as a template. The layers of nanoparticles were constructed based on the electrostatic [...] Read more.
In recent years, natural polysaccharides have been widely used in the preparation of drug delivery systems. In this paper, novel polysaccharide-based nanoparticles were prepared by layer-by-layer assembly technology using silica as a template. The layers of nanoparticles were constructed based on the electrostatic interaction between a new pectin named NPGP and chitosan (CS). The targeting ability of nanoparticles was formed by grafting the RGD peptide, a tri-peptide motif containing arginine, glycine, and aspartic acid with high affinity to integrin receptors. The layer-by-layer assembly nanoparticles (RGD-(NPGP/CS)3NPGP) exhibited a high encapsulation efficiency (83.23 ± 6.12%), loading capacity (76.51 ± 1.24%), and pH-sensitive release property for doxorubicin. The RGD-(NPGP/CS)3NPGP nanoparticles showed better targeting to HCT-116 cells, the integrin αvβ3 high expression human colonic epithelial tumor cell line with higher uptake efficiency than MCF7 cells, the human breast carcinoma cell line with normal integrin expression. In vitro antitumor activity tests showed that the doxorubicin-loaded nanoparticles could effectively inhibit the proliferation of the HCT-116 cells. In conclusion, RGD-(NPGP/CS)3NPGP nanoparticles have potential as novel anticancer drug carriers because of their good targeting and drug-carrying activity. Full article
(This article belongs to the Special Issue Advanced Polymer-Based Composites for Biomedical Applications)
►▼ Show Figures

Figure 1

16 pages, 2260 KiB  
Article
Microbially Synthesized Polymer-Metal Nanoparticles Composites as Promising Wound Dressings to Overcome Methicillin-Resistance Staphylococcus aureus Infections
by Jennifer Balcucho, Diana M. Narváez, Natalia A. Tarazona and Jinneth Lorena Castro-Mayorga
Polymers 2023, 15(4), 920; https://doi.org/10.3390/polym15040920 - 12 Feb 2023
Cited by 3 | Viewed by 1632
Abstract
Antimicrobial resistance has been declared one of the top 10 global public health threats. Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of recurring skin and soft tissue infections in patients with chronic skin conditions such as diabetic foot infections, making the treatment [...] Read more.
Antimicrobial resistance has been declared one of the top 10 global public health threats. Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of recurring skin and soft tissue infections in patients with chronic skin conditions such as diabetic foot infections, making the treatment of the ulcers challenging. Wound dressings combined with metal nanoparticles have been suggested to prevent and treat MRSA-infected wounds. However, these particles are commonly synthesized by chemical approaches. In this study, we developed bio-based silver (Bio-AgNPs) and copper oxide nanoparticles (CuONPs) polymer composites using a microbially produced polyester from the Polyhydroxyalkanoates (PHAs) family. Poly(3-hydroxyoctanoate)-co-(3-hydroxyhexanoate) (PHO) was synthesized by Pseudomonas putida and functionalized in-situ with Bio-AgNPs or ex-situ with CuONPs. PHO-CuONPs films did not inhibit MRSA growth, while a reduction of 6.0 log CFU/mL was achieved with PHO-Bio-AgNPs synthesized from silver nitrate (AgNO3) solution at 3.5 mM. Exposure of human fibroblast cells (HFF-1) to the bioactive films did not induce notable cytotoxicity and genotoxicity, as seen by a viability higher than 79% and no significant changes in basal DNA damage. However, exposure to PHO-Bio-AgNPs induced oxidative DNA damage in HFF-1 cells. No hemolytic potential was observed, while platelet aggregation was promoted and desired for wound healing. Here we demonstrate the biosynthesis of polymer-nanoparticle composites and their potential as bioactive films for MRSA treatment. Full article
(This article belongs to the Special Issue Advanced Polymer-Based Composites for Biomedical Applications)
►▼ Show Figures

Figure 1

15 pages, 2653 KiB  
Article
Porous Scaffolds Based on Polydopamine/Chondroitin Sulfate/Polyvinyl Alcohol Composite Hydrogels
by Zuwu Tang, Meiqiong Yu, Ajoy Kanti Mondal and Xinxing Lin
Polymers 2023, 15(2), 271; https://doi.org/10.3390/polym15020271 - 05 Jan 2023
Cited by 10 | Viewed by 1883
Abstract
In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength, lap shear strength, mass loss, [...] Read more.
In this paper, porous scaffolds based on composite hydrogels were fabricated using polydopamine (PDA), chondroitin sulfate (CS), and polyvinyl alcohol (PVA) via the freezing/thawing method. Different characteristics of the prepared composite hydrogels, including the pore sizes, compression strength, lap shear strength, mass loss, and cytocompatibility were investigated. Scanning electron microscope images (SEM) displayed the hydrogel pore sizes, ranging from 20 to 100 μm. The composite hydrogel exhibited excellent porosity of 95.1%, compression strength of 5.2 MPa, lap shear strength of 21 kPa on porcine skin, and mass loss of 16.0%. In addition, the composite hydrogel possessed good relative cell activity of 97%. The PDA/CS/PVA hydrogel is cytocompatible as a starting point, and it can be further investigated in tissue engineering. Full article
(This article belongs to the Special Issue Advanced Polymer-Based Composites for Biomedical Applications)
►▼ Show Figures

Figure 1

Review

Jump to: Research

19 pages, 4594 KiB  
Review
Sorafenib-Based Drug Delivery Systems: Applications and Perspectives
by Lingyun Wang, Meihuan Chen, Xueguang Ran, Hao Tang and Derong Cao
Polymers 2023, 15(12), 2638; https://doi.org/10.3390/polym15122638 - 09 Jun 2023
Cited by 4 | Viewed by 2091
Abstract
As a Food and Drug Administration (FDA)-approved molecular-targeted chemotherapeutic drug, sorafenib (SF) can inhibit angiogenesis and tumor cell proliferation, leading to improved patient overall survival of hepatocellular carcinoma (HCC). In addition, SF is an oral multikinase inhibitor as a single-agent therapy in renal [...] Read more.
As a Food and Drug Administration (FDA)-approved molecular-targeted chemotherapeutic drug, sorafenib (SF) can inhibit angiogenesis and tumor cell proliferation, leading to improved patient overall survival of hepatocellular carcinoma (HCC). In addition, SF is an oral multikinase inhibitor as a single-agent therapy in renal cell carcinoma. However, the poor aqueous solubility, low bioavailability, unfavorable pharmacokinetic properties and undesirable side effects (anorexia, gastrointestinal bleeding, and severe skin toxicity, etc.) seriously limit its clinical application. To overcome these drawbacks, the entrapment of SF into nanocarriers by nanoformulations is an effective strategy, which delivers SF in a target tumor with decreased adverse effects and improved treatment efficacy. In this review, significant advances and design strategies of SF nanodelivery systems from 2012 to 2023 are summarized. The review is organized by type of carriers including natural biomacromolecule (lipid, chitosan, cyclodextrin, etc.); synthetic polymer (poly(lactic-co-glycolic acid), polyethyleneimine, brush copolymer, etc.); mesoporous silica; gold nanoparticles; and others. Co-delivery of SF and other active agents (glypican-3, hyaluronic acid, apolipoprotein peptide, folate, and superparamagnetic iron oxide nanoparticles) for targeted SF nanosystems and synergistic drug combinations are also highlighted. All these studies showed promising results for targeted treatment of HCC and other cancers by SF-based nanomedicines. The outlook, challenges and future opportunities for the development of SF-based drug delivery are presented. Full article
(This article belongs to the Special Issue Advanced Polymer-Based Composites for Biomedical Applications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop