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Polymeric Materials for Drug Delivery and Tissue Engineering Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 13994

Special Issue Editors


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Guest Editor
Tissue Engineering and Nanopharmaceuticals Research Laboratory, Office of Vice President for Research & Graduate Studies, Qatar University, Doha, Qatar
Interests: biomaterials; photopolymerization; electrospinning; 3D printing; protein drug delivery; tissue engineering; controlled release; biopharmaceutics; pharmacokinetics

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Guest Editor
1. Faculty of Science, Engineering and Computing, Kingston University London, Penrhyn Road, Kingston upon Thames, London KT1 2EE, UK
2. Faculty of Medical and Health Sciences, The University of Auckland, Auckland CBD, Auckland 1010, New Zealand
Interests: ophthalmic drugs and delivery systems; veterinary pharmaceuticals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymeric materials (natural, synthetic, or hybrid formulations) are currently considered one of the cornerstones in drug delivery and tissue engineering advancements. Due to their wide range of properties (physicochemical, thermal, mechanical), scientists consider them ideal matrices in the design of delivery systems or scaffolds for tissue engineering applications.

The main aim of this Special Issue is to address the latest scientific approaches and techniques taken by researchers while employing various polymeric matrices to overcome the challenges faced in drug delivery and tissue engineering. For this Special Issue we welcome submissions in the form of reviews and full research articles that present multidisciplinary research efforts in synthesizing new polymeric materials or employing existing polymers in advanced controlled and targeted drug delivery functionality, nanotechnology, micropatterning, microfluidics, photocuring, and other technologies utilized in the pharmaceutical and biomedical fields. We also welcome submissions directed to using polymeric materials in fabricating three-dimensional matrices and rendering them deliverable through minimally invasive techniques and those engineered to achieve specific biological effects on cells and tissue regeneration.

Prof. Dr. Husam Younes
Prof. Dr. Raid Alany
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable polymers
  • biomaterials
  • functional polymers
  • drug delivery
  • tissue engineering
  • regenerative medicine
  • controlled release
  • microparticles
  • nanoparticles
  • biomimetic scaffolds
  • polymeric electrospun nanofibers
  • injectable polymers
  • photocured polymers
  • polymeric implants
  • polymeric ink for 3D printing

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Published Papers (3 papers)

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Review

22 pages, 3829 KiB  
Review
Manufacturing Process of Hyaluronic Acid Dermal Fillers
by Gi-Woong Hong, Jovian Wan, Youngjin Park, Jane Yoo, Hugues Cartier, Sebastien Garson, Diala Haykal and Kyu-Ho Yi
Polymers 2024, 16(19), 2739; https://doi.org/10.3390/polym16192739 - 27 Sep 2024
Cited by 2 | Viewed by 7866
Abstract
Hyaluronic acid (HA) fillers are extensively utilized in aesthetic medicine due to their biocompatibility, reversibility, and effectiveness in enhancing skin hydration, volume, and overall appearance. These fillers are predominantly produced through microbial fermentation, followed by a critical cross-linking process that enhances their longevity [...] Read more.
Hyaluronic acid (HA) fillers are extensively utilized in aesthetic medicine due to their biocompatibility, reversibility, and effectiveness in enhancing skin hydration, volume, and overall appearance. These fillers are predominantly produced through microbial fermentation, followed by a critical cross-linking process that enhances their longevity by resisting enzymatic degradation. This review provides a thorough examination of the manufacturing processes that differentiate HA fillers, with particular attention to the distinctions between biphasic and monophasic variants. Unlike previous studies, this review emphasizes the specific cross-linking techniques and their substantial impact on the fillers’ rheological properties, such as elasticity and cohesiveness, which are crucial to their clinical performance and patient outcomes. Additionally, the review offers a comprehensive comparison of HA fillers with non-HA alternatives, including calcium hydroxylapatite, poly-l-lactic acid, and polymethyl methacrylate, highlighting the unique advantages and potential complications associated with each type. By presenting novel insights into the latest advancements and challenges in filler technology, this review aims to provide clinicians with a deeper understanding of filler properties, thereby guiding them in making informed decisions to optimize patient safety and aesthetic results. Full article
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24 pages, 4857 KiB  
Review
Rheological Characteristics of Hyaluronic Acid Fillers as Viscoelastic Substances
by Gi-Woong Hong, Jovian Wan, Youngjin Park, Kathleen Chang, Lisa Kwin Wah Chan, Kar Wai Alvin Lee and Kyu-Ho Yi
Polymers 2024, 16(16), 2386; https://doi.org/10.3390/polym16162386 - 22 Aug 2024
Cited by 2 | Viewed by 3218
Abstract
Hyaluronic acid (HA) fillers are widely used in esthetic medicine and are categorized into biphasic and monophasic types based on their manufacturing processes. To evaluate the quality of these fillers, it is essential to understand their rheological properties, which reflect their viscoelastic nature. [...] Read more.
Hyaluronic acid (HA) fillers are widely used in esthetic medicine and are categorized into biphasic and monophasic types based on their manufacturing processes. To evaluate the quality of these fillers, it is essential to understand their rheological properties, which reflect their viscoelastic nature. Rheology, the study of material deformation and flow, reveals how fillers behave under stress, combining properties of solids and liquids. This study explores the fundamental principles of elasticity and viscosity, rooted in Hooke’s law of elasticity and Newton’s law of viscosity, to explain the complex behavior of viscoelastic substances like HA fillers. The distinction between biphasic and monophasic fillers lies in their chemical cross-linking processes, which impact their molecular weight, structure, and ultimately, their clinical performance. Biphasic fillers with minimal cross-linking rely on natural molecular entanglements, exhibiting lower modification efficiency and greater elasticity. Conversely, monophasic fillers, which undergo extensive chemical cross-linking, demonstrate higher modification efficiency, firmer texture, and enhanced resistance to enzymatic degradation. The study emphasizes the importance of thoroughly removing residual cross-linking agents to ensure filler safety. Understanding these rheological characteristics aids clinicians in selecting appropriate fillers based on injection sites, tissue conditions, and desired outcomes, balancing viscoelastic properties and safety for optimal esthetic results. Full article
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27 pages, 3143 KiB  
Review
Injectable Hydrogels in Cardiovascular Tissue Engineering
by Raj Patel and Dhruvi Patel
Polymers 2024, 16(13), 1878; https://doi.org/10.3390/polym16131878 - 1 Jul 2024
Cited by 6 | Viewed by 2766
Abstract
Heart problems are quite prevalent worldwide. Cardiomyocytes and stem cells are two examples of the cells and supporting matrix that are used in the integrated process of cardiac tissue regeneration. The objective is to create innovative materials that can effectively replace or repair [...] Read more.
Heart problems are quite prevalent worldwide. Cardiomyocytes and stem cells are two examples of the cells and supporting matrix that are used in the integrated process of cardiac tissue regeneration. The objective is to create innovative materials that can effectively replace or repair damaged cardiac muscle. One of the most effective and appealing 3D/4D scaffolds for creating an appropriate milieu for damaged tissue growth and healing is hydrogel. In order to successfully regenerate heart tissue, bioactive and biocompatible hydrogels are required to preserve cells in the infarcted region and to bid support for the restoration of myocardial wall stress, cell survival and function. Heart tissue engineering uses a variety of hydrogels, such as natural or synthetic polymeric hydrogels. This article provides a quick overview of the various hydrogel types employed in cardiac tissue engineering. Their benefits and drawbacks are discussed. Hydrogel-based techniques for heart regeneration are also addressed, along with their clinical application and future in cardiac tissue engineering. Full article
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