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Polymeric Materials for Wound Dressing

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 771

Special Issue Editor

MOE Key Laboratory of Advanced Textile Materials & Manufacturing Technology, Zhejiang Sci-Tech University, Hangzhou 310018, China
Interests: wound dressings; hydrogels; antibacterial polymers; theranostics; anti-adhesion

Special Issue Information

Dear Colleagues,

This Special Issue, ‘Polymeric Materials for Wound Dressing’, is devoted to the publication of high-quality original research articles and comprehensive reviews that highlight cutting-edge advances in this vital interdisciplinary area. In recent years, polymeric materials have played an increasingly critical role in wound care due to their tunable physical, mechanical, and biological properties. The development of innovative wound dressings, such as hydrogels, fibrous membranes, smart responsive systems, and biocomposites, offers promising strategies for enhancing healing outcomes, preventing infections, and managing complex wounds.

We welcome contributions that explore the synthesis, characterization, fabrication, and application of polymeric materials designed for wound dressings. Potential topics include, but are not limited to, the following:

  • Design and synthesis of functional polymers for wound dressing;
  • Advanced characterization and performance evaluation;
  • Hydrogel, foam, film, and electrospun-fiber-based dressings;
  • Antibacterial and bioactive polymeric dressings;
  • Smart and stimuli-responsive wound care materials;
  • Biodegradable and bio-based polymer systems;
  • Three-dimensional-printed and personalized wound dressing solutions;
  • Clinical translation and regulatory aspects.

We look forward to receiving your innovative research and insightful reviews that will help advance the field of polymeric wound dressings.

Dr. Yujie Gao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound dressings
  • hydrogels
  • electrospinning and nanofibers
  • antibacterial polymers bioactive dressings
  • smart wound dressings
  • biodegradable polymers
  • 3D printing in wound care
  • clinical applications

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Published Papers (1 paper)

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Research

21 pages, 6168 KB  
Article
3D-Bioprinted Gelatin Hydrogels with Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Cutaneous Wound Healing In Vivo
by Manal Hussein Taghdi, Ibrahim N. Amirrah, Nurul Izzati Uda Zahli, Kavita Chirara, Mh Busra Fauzi, Jia Xian Law and Yogeswaran Lokanathan
Polymers 2026, 18(7), 882; https://doi.org/10.3390/polym18070882 - 3 Apr 2026
Viewed by 520
Abstract
Small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) are emerging as potent acellular therapeutics; however, their rapid clearance hinders their clinical translation. To address this issue, 3D-bioprinted genipin-crosslinked gelatin (GECL) was engineered for human health. GECL hydrogels were functionalised with human [...] Read more.
Small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) are emerging as potent acellular therapeutics; however, their rapid clearance hinders their clinical translation. To address this issue, 3D-bioprinted genipin-crosslinked gelatin (GECL) was engineered for human health. GECL hydrogels were functionalised with human umbilical cord MSC-derived sEVs (hUCMSC-sEVs) to create a bioactive wound-healing platform. These hydrogels demonstrated favourable physicochemical, mechanical, and biodegradable properties while providing an extracellular matrix (ECM)-mimetic environment conducive to tissue regeneration. MSCs were isolated from the umbilical cords, and their small extracellular vesicles (sEVs) were extracted and incorporated into gelatin-based hydrogels via 3D bioprinting. These sEV-loaded scaffolds were embedded in full-thickness wounds in mice, and healing was evaluated through macroscopic observation, histological analysis, collagen deposition, and angiogenesis assessment. Compared with the untreated controls, both the hydrogel-only (B) and sEV-loaded hydrogel (BE) groups significantly accelerated in vivo wound healing. Notably, the BE group achieved complete wound closure within 14 days, restoring the skin architecture, which closely resembled the native tissue with well-organised epidermal and dermal layers, optimal thickness, and skin appendages. Histological and ultrastructural assessments revealed an increased collagen type I deposition, a reduced α-smooth muscle actin (α-SMA) expression, and a robust neovascularisation. The TEM revealed tight junctions and active cellular infiltration, indicating scaffold integration and functional remodelling. Immunohistochemistry further revealed an upregulated CD31 expression with a balanced α-smooth muscle actin (α-SMA) expression, reflecting coordinated angiogenesis and myofibroblast regulation. These results highlight sEV-functionalised GECL hydrogels as robust and clinically translatable acellular therapeutic green products for accelerated wound closure and functional skin regeneration, advancing the fields of regenerative medicine and life expectancy. Full article
(This article belongs to the Special Issue Polymeric Materials for Wound Dressing)
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