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Design and Synthesis of Dendrimers

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Analysis and Characterization".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 2535

Special Issue Editors


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Guest Editor
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior Ciudad Universitaria, Mexico City C.P. 04510, Mexico
Interests: dendrimers; fluorescence; energy transfer; chemosensors; hydrogels; pyrene; coumarin
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México City CP 04510, Mexico
Interests: fluorescence; energy transfer; supramolecular chemistry; DFT calculations
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior Ciudad Universitaria, Mexico City C.P. 04510, Mexico
Interests: dendrimer; fluorescence; energy transfer; pyrene; polythiophenes; azo dyes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dendrimers are well-defined tree-like structures composed of a core surrounded by branches and multiple end-groups. The molecular weight and the polydispersity are factors that can be controlled in the synthesis of dendrimers. Furthermore, photoactive groups can be incorporated into the structures of dendrimers. Therefore, dendrimers have attracted the attention of scientists and have found several applications in optoelectronics, catalysis, sensing, and drug delivery, among other areas.

This Special Issue, entitled "Design and Synthesis of Dendrimers", will focus on innovative strategies for the design and synthesis of dendritic macromolecules. This Special Issue will feature original research articles and reviews that explore the synthesis of dendrimers with tailored functionalities. Contributions that investigate the photophysical properties of dendrimers, such as fluorescence, phosphorescence, and light-harvesting capabilities, are encouraged. Additionally, studies on applications for dendrimers in medicine, as well as on the integration of dendrimers into advanced materials, are welcome. 

Dr. Mireille Vonlanthen
Dr. Fabián Cuétara-Guadarrama
Prof. Dr. Ernesto Rivera
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dendrimers
  • design
  • synthesis
  • optical properties
  • photophysical properties
  • drug delivery
  • imaging
  • sensing
  • light harvesting
  • nanomedicine

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Published Papers (1 paper)

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Research

21 pages, 9723 KB  
Article
Experimental and Computational Analysis of Phenolic Acid Association with PAMAM Dendrimers: Comparing Different Formulation Techniques
by Christopher Sbarbaro, Ma. Andreina Rangel-Ramírez, Emilio Salas, Francisco Salgado, María Carolina Otero, Alvaro A. Elorza, Fernando González-Nilo, Valeria Márquez-Miranda and Yorley Duarte
Polymers 2026, 18(9), 1086; https://doi.org/10.3390/polym18091086 - 29 Apr 2026
Viewed by 558
Abstract
Poly(amidoamine) (PAMAM) dendrimers are widely recognized as versatile nanocarriers due to their tunable architecture and ability to associate with bioactive molecules. In this study, generation 3 PAMAM dendrimers functionalized with triphenylphosphonium (TPP) were employed to investigate the association of structurally related phenolic compounds—caffeic [...] Read more.
Poly(amidoamine) (PAMAM) dendrimers are widely recognized as versatile nanocarriers due to their tunable architecture and ability to associate with bioactive molecules. In this study, generation 3 PAMAM dendrimers functionalized with triphenylphosphonium (TPP) were employed to investigate the association of structurally related phenolic compounds—caffeic acid, p-coumaric acid, and cinnamic acid—through either covalent conjugation or non-covalent encapsulation. Physicochemical characterization by NMR, dynamic light scattering, and zeta potential measurements revealed the formation of supramolecular aggregates rather than isolated dendrimer units, with hydrodynamic diameters ranging from 127 to 260 nm and positive surface charge across all formulations. Encapsulation efficiencies determined by HPLC reached 93.8% for caffeic acid, 78.9% for p-coumaric acid, and 71% for cinnamic acid, indicating differential association behavior. Molecular dynamics simulations over 1 μs supported these findings, showing stronger and more stable interactions for polar antioxidants, particularly caffeic acid, driven by hydrogen bonding and electrostatic interactions, while cinnamic acid displayed preferential binding in more hydrophobic dendrimer regions. Radical scavenging assays (DPPH• and ABTS•+) demonstrated that all formulations retained antioxidant capacity, although dendrimer association modulated scavenging kinetics. In cellular assays under oxidative stress, free caffeic acid exhibited the strongest immediate reduction of intracellular reactive oxygen species, whereas dendrimer-associated systems showed reduced but significant activity, consistent with decreased solvent accessibility and slower release predicted by simulations. Overall, these results highlight a trade-off between molecular retention and immediate biological efficacy, demonstrating that the mode of association governs antioxidant accessibility and performance. This combined experimental and computational approach provides a mechanistic framework for the rational design of dendrimer-based delivery systems aimed at balancing stability and functional activity. Full article
(This article belongs to the Special Issue Design and Synthesis of Dendrimers)
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